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March Myoglobinemia

March Myoglobinemia Abstract To the Editor. —This letter is concerning the article entitled "March Myoglobinemia: A Hazard to Renal Function" by Melamed et al published in the July Archives (1982;142:1277-1279). Melamed et al noted that episodic bouts of progressively intense exercise by soldiers in a training program may cause deterioration of renal function. Endogenous 24-hour creatinine clearance was serially determined before the start of training and on days of hikes measuring 10, 30, and 45 km on weeks 2, 5, and 8, respectively. After a slight rise on the day of the first hike, creatinine clearance fell with each successive hike and was about half normal on the last one. During each hike, there appeared chemical evidence of minor rhabdomyolysis and myoglobinuria that are well known to occur under such conditions.Melamed et al suggested that myoglobinemia and myoglobinuria, although subtle, were probably responsible for the apparent decline of creatinine clearance. They cautioned References 1. Radigan LR, Robinson S: Effects of environmental heat stress on renal blood flow and filtration rate. J Appl Physiol 1949;2:185-191. 2. Knochel JP, Dotin LN, Hamburger RJ: Heat stress, exercise, and muscle injury: Effects on urate metabolism and renal function. Ann Intern Med 1974;81:321-328.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

March Myoglobinemia

Abstract

Abstract To the Editor. —This letter is concerning the article entitled "March Myoglobinemia: A Hazard to Renal Function" by Melamed et al published in the July Archives (1982;142:1277-1279). Melamed et al noted that episodic bouts of progressively intense exercise by soldiers in a training program may cause deterioration of renal function. Endogenous 24-hour creatinine clearance was serially determined before the start of training and on days of hikes measuring 10, 30, and 45...
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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1983.00350020220050
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —This letter is concerning the article entitled "March Myoglobinemia: A Hazard to Renal Function" by Melamed et al published in the July Archives (1982;142:1277-1279). Melamed et al noted that episodic bouts of progressively intense exercise by soldiers in a training program may cause deterioration of renal function. Endogenous 24-hour creatinine clearance was serially determined before the start of training and on days of hikes measuring 10, 30, and 45 km on weeks 2, 5, and 8, respectively. After a slight rise on the day of the first hike, creatinine clearance fell with each successive hike and was about half normal on the last one. During each hike, there appeared chemical evidence of minor rhabdomyolysis and myoglobinuria that are well known to occur under such conditions.Melamed et al suggested that myoglobinemia and myoglobinuria, although subtle, were probably responsible for the apparent decline of creatinine clearance. They cautioned References 1. Radigan LR, Robinson S: Effects of environmental heat stress on renal blood flow and filtration rate. J Appl Physiol 1949;2:185-191. 2. Knochel JP, Dotin LN, Hamburger RJ: Heat stress, exercise, and muscle injury: Effects on urate metabolism and renal function. Ann Intern Med 1974;81:321-328.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Feb 1, 1983

References