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MAPHARSEN (ARSENOXIDE) IN THE THERAPY OF EXPERIMENTAL SYPHILIS AND TRYPANOSOMIASIS

MAPHARSEN (ARSENOXIDE) IN THE THERAPY OF EXPERIMENTAL SYPHILIS AND TRYPANOSOMIASIS Abstract After the synthesis of arsphenamine by Ehrlich and Bertheim1 and its successful introduction by Ehrlich and Hata2 in the therapy of spirillosis and by Wechselmann3 and Uhlenhuth and Mulzer4 in the treatment of syphilis, a considerable attempt has been made to ascertain the mode of action of the arsphenamines. Ehrlich and Hata2 stated that arsphenamine exerted no direct action in the test tube on spirochetes of relapsing fever. Plaut,5 Truffi and Sabbia6 and Bronfenbrenner and Noguchi7 were not able to kill Spirochaeta pallida in the test tube with high concentrations of arsphenamine. Ehrlich and Bertheim1 assumed that the active principle was a product of the breaking down of arsphenamine, the "arsenoxide." Voegtlin and Smith8 produced convincing evidence that the action of the various arsphenamines depends on their conversion into one type, the trivalent oxides with the structure R-AsO, and References 1. Ehrlich, P., and Bertheim, A.: Ueber das Salzsaure Diamino-3.3′-dioxy-4.4′ arsenobenzol und seine nächsten Verwandten , Ber. d. deutsch. chem. Gesellsch. 45:756, 1912.Crossref 2. Ehrlich, P., and Hata, S.: Die experimentelle Chemotherapie der Spirillosen , Berlin, Julius Springer, 1910. 3. Wechselmann, W.: Ueber die Behandlung der Syphilis mit Dioxydiamino-arsenobenzol , Berl. klin. Wchnschr. 47:1261, 1910. 4. Uhlenhuth, P., and Mulzer, P.: Die experimentellen Grundlagen chemotherapeutischer Versuche mit neueren Arsen-Präparaten , Deutsche med. Wchnschr. 36:1262, 1910.Crossref 5. Plaut, H. C.: Technische und biologische Erfahrungen mit 606 , Deutsche med. Wchnschr. 36:2237, 1910.Crossref 6. Truffi, M., and Sabbia, U.: Pathologica 3:642, 1911. 7. Bronfenbrenner, J., and Noguchi, H.: On the Resistance of Various Spirochaetes in Cultures to the Action of Chemical and Physical Agents , J. Pharmacol. & Exper. Therap. 4:333, 1913. 8. Voegtlin, C., and Smith, H. W.: Quantitative Studies in Chemotherapy , J. Pharmacol. & Exper. Therap. 15:475, 1920 9. 16:199 and 449, 1920. 10. Voegtlin, C.; Dyer, H. A., and Leonard, C. S.: The Mechanism of the Action of Arsenic upon Protoplasm , Pub. Health Rep. 38:1882, 1923. 11. Rosenthal, S. M.: The Formation of Arsenoxide from the Arsphenamines in the Living Animal and in Test-Tube Oxidations , Pub. Health Rep. 47:933, 1932. 12. Voegtlin, C.: The Pharmacology of Arsphenamine (Salvarsan) and Related Arsenicals , Physiol. Rev. 5:63, 1925. 13. Hunt, R.: Some Factors Relating to the Toxic Action of Arsphenamine , J. A. M. A. 76:854 ( (March 26) ) 1921. 14. Dale, H. H.: Chemotherapy , Physiol. Rev. 3:369, 1923. 15. Tatum, A. L., and Cooper, G. A.: (a) Meta-Amino-Para-Hydroxy Phenyl Arsine Oxide as an Antisyphilitic Agent , Science 75:541, 1932 16. (b) An Experimental Study of Mapharsen as an Antisyphilitic Agent , J. Pharmacol. & Exper. Therap. 50:198, 1934. 17. Throughout this paper the doses are expressed in milligrams per kilogram of body weight. 18. Gruhzit, O. M.: Arsenoxide in Experimental Animals , Arch. Path. 18:582 ( (Oct.) ) 1934. 19. Wechselmann, W.; Lochemann, G., and Ulrich, W.: Ueber den Arsengehalt von Blut und Harn nach intravenöser Einspritzung verschiedener Salvarsanpräparate und seine Beziehung zu den Salvarsanschädigungen , Arch. f. Dermat. u. Syph. 142:163, 1923. 20. Kolmer, J. A.: Chemotherapy: Treatment of Syphilis , Philadelphia, W. B. Saunders Company, 1926, p. 553. 21. The clinical study of mapharsen will be presented in another paper http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

MAPHARSEN (ARSENOXIDE) IN THE THERAPY OF EXPERIMENTAL SYPHILIS AND TRYPANOSOMIASIS

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References (12)

Publisher
American Medical Association
Copyright
Copyright © 1935 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1935.01470060013002
Publisher site
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Abstract

Abstract After the synthesis of arsphenamine by Ehrlich and Bertheim1 and its successful introduction by Ehrlich and Hata2 in the therapy of spirillosis and by Wechselmann3 and Uhlenhuth and Mulzer4 in the treatment of syphilis, a considerable attempt has been made to ascertain the mode of action of the arsphenamines. Ehrlich and Hata2 stated that arsphenamine exerted no direct action in the test tube on spirochetes of relapsing fever. Plaut,5 Truffi and Sabbia6 and Bronfenbrenner and Noguchi7 were not able to kill Spirochaeta pallida in the test tube with high concentrations of arsphenamine. Ehrlich and Bertheim1 assumed that the active principle was a product of the breaking down of arsphenamine, the "arsenoxide." Voegtlin and Smith8 produced convincing evidence that the action of the various arsphenamines depends on their conversion into one type, the trivalent oxides with the structure R-AsO, and References 1. Ehrlich, P., and Bertheim, A.: Ueber das Salzsaure Diamino-3.3′-dioxy-4.4′ arsenobenzol und seine nächsten Verwandten , Ber. d. deutsch. chem. Gesellsch. 45:756, 1912.Crossref 2. Ehrlich, P., and Hata, S.: Die experimentelle Chemotherapie der Spirillosen , Berlin, Julius Springer, 1910. 3. Wechselmann, W.: Ueber die Behandlung der Syphilis mit Dioxydiamino-arsenobenzol , Berl. klin. Wchnschr. 47:1261, 1910. 4. Uhlenhuth, P., and Mulzer, P.: Die experimentellen Grundlagen chemotherapeutischer Versuche mit neueren Arsen-Präparaten , Deutsche med. Wchnschr. 36:1262, 1910.Crossref 5. Plaut, H. C.: Technische und biologische Erfahrungen mit 606 , Deutsche med. Wchnschr. 36:2237, 1910.Crossref 6. Truffi, M., and Sabbia, U.: Pathologica 3:642, 1911. 7. Bronfenbrenner, J., and Noguchi, H.: On the Resistance of Various Spirochaetes in Cultures to the Action of Chemical and Physical Agents , J. Pharmacol. & Exper. Therap. 4:333, 1913. 8. Voegtlin, C., and Smith, H. W.: Quantitative Studies in Chemotherapy , J. Pharmacol. & Exper. Therap. 15:475, 1920 9. 16:199 and 449, 1920. 10. Voegtlin, C.; Dyer, H. A., and Leonard, C. S.: The Mechanism of the Action of Arsenic upon Protoplasm , Pub. Health Rep. 38:1882, 1923. 11. Rosenthal, S. M.: The Formation of Arsenoxide from the Arsphenamines in the Living Animal and in Test-Tube Oxidations , Pub. Health Rep. 47:933, 1932. 12. Voegtlin, C.: The Pharmacology of Arsphenamine (Salvarsan) and Related Arsenicals , Physiol. Rev. 5:63, 1925. 13. Hunt, R.: Some Factors Relating to the Toxic Action of Arsphenamine , J. A. M. A. 76:854 ( (March 26) ) 1921. 14. Dale, H. H.: Chemotherapy , Physiol. Rev. 3:369, 1923. 15. Tatum, A. L., and Cooper, G. A.: (a) Meta-Amino-Para-Hydroxy Phenyl Arsine Oxide as an Antisyphilitic Agent , Science 75:541, 1932 16. (b) An Experimental Study of Mapharsen as an Antisyphilitic Agent , J. Pharmacol. & Exper. Therap. 50:198, 1934. 17. Throughout this paper the doses are expressed in milligrams per kilogram of body weight. 18. Gruhzit, O. M.: Arsenoxide in Experimental Animals , Arch. Path. 18:582 ( (Oct.) ) 1934. 19. Wechselmann, W.; Lochemann, G., and Ulrich, W.: Ueber den Arsengehalt von Blut und Harn nach intravenöser Einspritzung verschiedener Salvarsanpräparate und seine Beziehung zu den Salvarsanschädigungen , Arch. f. Dermat. u. Syph. 142:163, 1923. 20. Kolmer, J. A.: Chemotherapy: Treatment of Syphilis , Philadelphia, W. B. Saunders Company, 1926, p. 553. 21. The clinical study of mapharsen will be presented in another paper

Journal

Archives of Dermatology and Syphilology – American Medical Association

Published: Dec 1, 1935

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