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Management of Hereditary Site-Specific Colon Cancer

Management of Hereditary Site-Specific Colon Cancer Abstract • A family with site-specific colon cancer and discrete adenomatous colon polyps in certain members has provided a prototype for the study and clinical management of hereditary cancer. Analysis of this kindred showed an autosomal dominant mode of inheritance, early onset of cancer with predilection for the right colon, and frequent extraprimary cancers of the colon. Knowledge of these phenomena are critical to the management of this hereditary cancer syndrome. On our recommendation, two brothers of the family who were treated for colon cancer by hemicolectomy underwent prophylactic total colectomy. The resected colon from one of these patients had an occult adenocarcinoma in a villoglandular polyp. (Arch Surg 112:170-174, 1977) References 1. Lynch P, Lynch H, Harris R, et al: Heritable Colon Cancer and Solitary Adenomatous Polyps. Proceedings of the Third International Symposium on Detection and Prevention of Cancer, April 26-30, 1976. New York, Marcell Dekker Inc, to be published. 2. Colton T: Statistics in Medicine . Boston, Little Brown & Co, 1974, pp 244-249. 3. Lynch HT, Krush AJ: The cancer family syndrome and cancer control . Surg Gynecol Obstet 132:247-250, 1971. 4. Keiser HR, Beavan MA, Doppman J, et al: Sipple's syndrome: Medullary thyroid carcinoma, pheochromocytoma, and parathyroid disease . Ann Intern Med 78:561-579, 1973.Crossref 5. Lynch HT: Skin, Heredity, and Malignant Neoplasms . Flushing, NY, Medical Examination Publishing Co Inc, 1972, p 299. 6. Lipkin M, Deschner E: Early proliferative changes in intestinal cells . Cancer Res 36:2665-2668, 1976. 7. Lynch HT: Cancer Genetics . Springfield, Ill, Charles C Thomas Publisher, 1976, p 639. 8. Fraumeni JF, Jr: Persons at High Risk of Cancer: An Approach to Cancer Etiology and Control . New York, Academic Press Inc, 1975, p 544. 9. Lynch HT: Dynamic Genetic Counseling for Clinicians . Springfield, Ill, Charles C Thomas Publisher, 1969, p 354. 10. Woolf CM, Richards RC, Gardner EJ: Occasional discrete polyps of the colon and rectum showing an inherited tendency in a kindred . Cancer 8:403-408, 1955.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1977 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1977.01370020064007
Publisher site
See Article on Publisher Site

Abstract

Abstract • A family with site-specific colon cancer and discrete adenomatous colon polyps in certain members has provided a prototype for the study and clinical management of hereditary cancer. Analysis of this kindred showed an autosomal dominant mode of inheritance, early onset of cancer with predilection for the right colon, and frequent extraprimary cancers of the colon. Knowledge of these phenomena are critical to the management of this hereditary cancer syndrome. On our recommendation, two brothers of the family who were treated for colon cancer by hemicolectomy underwent prophylactic total colectomy. The resected colon from one of these patients had an occult adenocarcinoma in a villoglandular polyp. (Arch Surg 112:170-174, 1977) References 1. Lynch P, Lynch H, Harris R, et al: Heritable Colon Cancer and Solitary Adenomatous Polyps. Proceedings of the Third International Symposium on Detection and Prevention of Cancer, April 26-30, 1976. New York, Marcell Dekker Inc, to be published. 2. Colton T: Statistics in Medicine . Boston, Little Brown & Co, 1974, pp 244-249. 3. Lynch HT, Krush AJ: The cancer family syndrome and cancer control . Surg Gynecol Obstet 132:247-250, 1971. 4. Keiser HR, Beavan MA, Doppman J, et al: Sipple's syndrome: Medullary thyroid carcinoma, pheochromocytoma, and parathyroid disease . Ann Intern Med 78:561-579, 1973.Crossref 5. Lynch HT: Skin, Heredity, and Malignant Neoplasms . Flushing, NY, Medical Examination Publishing Co Inc, 1972, p 299. 6. Lipkin M, Deschner E: Early proliferative changes in intestinal cells . Cancer Res 36:2665-2668, 1976. 7. Lynch HT: Cancer Genetics . Springfield, Ill, Charles C Thomas Publisher, 1976, p 639. 8. Fraumeni JF, Jr: Persons at High Risk of Cancer: An Approach to Cancer Etiology and Control . New York, Academic Press Inc, 1975, p 544. 9. Lynch HT: Dynamic Genetic Counseling for Clinicians . Springfield, Ill, Charles C Thomas Publisher, 1969, p 354. 10. Woolf CM, Richards RC, Gardner EJ: Occasional discrete polyps of the colon and rectum showing an inherited tendency in a kindred . Cancer 8:403-408, 1955.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Feb 1, 1977

References