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Malignant Skin Tumors in Multiple Myeloma

Malignant Skin Tumors in Multiple Myeloma Abstract Two patients with multiple myeloma developed cutaneous myeloma tumors. Well-differentiated myeloma cells characterized the tumors of the first case; those of the second case were anaplastic, resembling reticulum cell sarcoma. The rarity of such cutaneous tumors is noted in a review of the literature. In addition, a morphologically less differentiated group of myeloma patients is apparent. Whether their anaplastic tumors are myeloma or a new malignancy is discussed. Bone marrow films differentiation. References 1. Helwig, C.A.: Extramedullary Plasma Cell Tumors as Observed in Various Locations , Arch Path 36:95, 1943. 2. Bluefarb, S.M.: Cutaneous Manifestations of Multiple Myeloma , Arch Derm 72:506, 1955.Crossref 3. Hayes, D.W.; Bennett, W.A. and Heck, F.J.: Extramedullary Lesions in Multiple Myeloma , Arch Path 53:262, 1952. 4. Bloch, B.: Uber eine bisher Nicht bescheribene mit eigentum-lichen Elastinveranderungen Einhergehende Dermatose bei Bence-Jonesscher Albuminurie: ein Beitrag zur Lehre von den Stoffwechseldermatosen , Arch Derm Syph (Berlin) 99:9, 1910.Crossref 5. Kreibich, C.: Plasmomyelom der Haut , Folia Haemat 18:94, 1914. 6. Mac Leod, J.M.H., and Peney, A.: Sections From a Case of Myeloma , Proc Roy Soc Med 16:1925-1926. 7. Nicholls, A.G.: Multiple Myeloma of Unusual Type With Widely Disseminated Metastases of Small Size , Canad Med Assoc J 17:301, 1927. 8. Piney, A., and Riach, J.S.: Multiple Myeloma: Aleukemic and Leukemic , Folia Haemat 46:37, 1931. 9. Newns, G.R., and Edwards, J.L.: A Case of Plasma-Cell Myelomatosis With a Large Renal Metastasis and Widespread Tubular Obstruction , J Path Bact 56:259, 1944.Crossref 10. Switzer, P.K.; Mosely, V.; and Cannon, W. M.: Extramedullary Plasmocytoma Involving Pharynx, Skin, and Lymph Nodes , Arch Intern Med 86:402, 1950.Crossref 11. Newman, W., et al: A Case of Acute Plasma-Cell Leukemia Supporting the Concept of Unity of Plasmacellular Neoplasia , Cancer 5:514, 1952.Crossref 12. Stritzler, C.: Multiple Myeloma, With Cutaneous Manifestations Simulating Lymphoma Cutis. Society Transactions of the Bronx Dermatological Society, Jan 16, 1958 , Arch Derm 78:664, 1958.Crossref 13. Cipollaro, A.C.: in Nelson, C.T., Primary Amyloidosis (and Plasma Cell Dyscrasia) , Arch Derm 92:109, 1965. 14. Shapiro: in Nelson, C.T., Primary Amyloidosis (and Plasma Cell Dyscrasia) , Arch Derm 92:109, 1965.Crossref 15. Wuketich, S.V., and Siegmund, G.: Multiples Plasmozytom Mit Uebergang in Yiesenzelliges Retikulosarkom , Wien Klin Wschr 73:473, 1961. 16. Snapper, I.; Turner, L.B.; and Moscovitz, H.L.: Multiple Myeloma , New York: Gruen and Stratton, Inc, 1953. 17. Waldenstrom, J.: Melphelan Therapy in Myelomatosis , Brit Med J 1:859, 1964.Crossref 18. Andrews, G.C., and Domonkos, A.N.: Diseases of the Skin , ed 5, Philadelphia: W. B. Saunders, 1963, pp 592. 19. Gate, J., et al: Une Forme Exceptionnelle de la Maladie Maligne a Plasmocytes: Reticulose Cutanee a Plasmocytes, ou Plasmocytosarcomatose Cutanee , Lyon Med 89:711, 1957. 20. Plauchu, M., and LeJeune, M.P.: Un Nouvel Aspect de la Maladie a Plasmocytes: La Reticulose Plasmocytaire Splenomegalique , Lyon Med 190:413, 1954. 21. Wintrobe, M.M.: Clinical Hematology , ed 5, Philadelphia: Lea and Febiger, 1961. 22. Korst, D.R., et al: Multiple Myeloma: II. Analysis of Cyclophosphamide Therapy in 165 Patients , JAMA 189:758, 1964.Crossref 23. Tourtellotte, C.R., and Call, M.K.: Prolonged Remission of Myeloma With Cyclophosphamide , Arch Intern Med 113:758, 1964.Crossref 24. Bergsagel, D.E.; Migliore, P.J.; and Griffith, K.M.: Myeloma Proteins and the Clinical Response to Melphelan Therapy , Science 148:376, 1965.Crossref 25. Osserman, E.F.: Letter to Editor , Science 149:564, 1965.Crossref 26. Lee, B.J.; Korngold, L.; and Weiner, M.F.: Letter to Editor , Science 149:565, 1965.Crossref 27. Tomasi, T.B., Jr.: Human Gamma Globulin , Blood 25:382, 1965. 28. Franklin, E.C., et al: An Unusual Micro-Gamma-Globulin in the Urine and Serum of a Patient , Fed Proc 22:264, 1963. 29. Rowe, D.S., and Fahey, J.L.: A New Class of Human Immunoglobulins , J Exp Med 121:185, 1965.Crossref 30. Braunsteiner, H.: Are Plasma Cells Derived From Lymphocytes? German Medical Monthly 9:469, 1964. 31. Domonkos, A.N.: Personal communication to the authors, March 31, 1965. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Malignant Skin Tumors in Multiple Myeloma

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Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1966.01600220044015
Publisher site
See Article on Publisher Site

Abstract

Abstract Two patients with multiple myeloma developed cutaneous myeloma tumors. Well-differentiated myeloma cells characterized the tumors of the first case; those of the second case were anaplastic, resembling reticulum cell sarcoma. The rarity of such cutaneous tumors is noted in a review of the literature. In addition, a morphologically less differentiated group of myeloma patients is apparent. Whether their anaplastic tumors are myeloma or a new malignancy is discussed. Bone marrow films differentiation. References 1. Helwig, C.A.: Extramedullary Plasma Cell Tumors as Observed in Various Locations , Arch Path 36:95, 1943. 2. Bluefarb, S.M.: Cutaneous Manifestations of Multiple Myeloma , Arch Derm 72:506, 1955.Crossref 3. Hayes, D.W.; Bennett, W.A. and Heck, F.J.: Extramedullary Lesions in Multiple Myeloma , Arch Path 53:262, 1952. 4. Bloch, B.: Uber eine bisher Nicht bescheribene mit eigentum-lichen Elastinveranderungen Einhergehende Dermatose bei Bence-Jonesscher Albuminurie: ein Beitrag zur Lehre von den Stoffwechseldermatosen , Arch Derm Syph (Berlin) 99:9, 1910.Crossref 5. Kreibich, C.: Plasmomyelom der Haut , Folia Haemat 18:94, 1914. 6. Mac Leod, J.M.H., and Peney, A.: Sections From a Case of Myeloma , Proc Roy Soc Med 16:1925-1926. 7. Nicholls, A.G.: Multiple Myeloma of Unusual Type With Widely Disseminated Metastases of Small Size , Canad Med Assoc J 17:301, 1927. 8. Piney, A., and Riach, J.S.: Multiple Myeloma: Aleukemic and Leukemic , Folia Haemat 46:37, 1931. 9. Newns, G.R., and Edwards, J.L.: A Case of Plasma-Cell Myelomatosis With a Large Renal Metastasis and Widespread Tubular Obstruction , J Path Bact 56:259, 1944.Crossref 10. Switzer, P.K.; Mosely, V.; and Cannon, W. M.: Extramedullary Plasmocytoma Involving Pharynx, Skin, and Lymph Nodes , Arch Intern Med 86:402, 1950.Crossref 11. Newman, W., et al: A Case of Acute Plasma-Cell Leukemia Supporting the Concept of Unity of Plasmacellular Neoplasia , Cancer 5:514, 1952.Crossref 12. Stritzler, C.: Multiple Myeloma, With Cutaneous Manifestations Simulating Lymphoma Cutis. Society Transactions of the Bronx Dermatological Society, Jan 16, 1958 , Arch Derm 78:664, 1958.Crossref 13. Cipollaro, A.C.: in Nelson, C.T., Primary Amyloidosis (and Plasma Cell Dyscrasia) , Arch Derm 92:109, 1965. 14. Shapiro: in Nelson, C.T., Primary Amyloidosis (and Plasma Cell Dyscrasia) , Arch Derm 92:109, 1965.Crossref 15. Wuketich, S.V., and Siegmund, G.: Multiples Plasmozytom Mit Uebergang in Yiesenzelliges Retikulosarkom , Wien Klin Wschr 73:473, 1961. 16. Snapper, I.; Turner, L.B.; and Moscovitz, H.L.: Multiple Myeloma , New York: Gruen and Stratton, Inc, 1953. 17. Waldenstrom, J.: Melphelan Therapy in Myelomatosis , Brit Med J 1:859, 1964.Crossref 18. Andrews, G.C., and Domonkos, A.N.: Diseases of the Skin , ed 5, Philadelphia: W. B. Saunders, 1963, pp 592. 19. Gate, J., et al: Une Forme Exceptionnelle de la Maladie Maligne a Plasmocytes: Reticulose Cutanee a Plasmocytes, ou Plasmocytosarcomatose Cutanee , Lyon Med 89:711, 1957. 20. Plauchu, M., and LeJeune, M.P.: Un Nouvel Aspect de la Maladie a Plasmocytes: La Reticulose Plasmocytaire Splenomegalique , Lyon Med 190:413, 1954. 21. Wintrobe, M.M.: Clinical Hematology , ed 5, Philadelphia: Lea and Febiger, 1961. 22. Korst, D.R., et al: Multiple Myeloma: II. Analysis of Cyclophosphamide Therapy in 165 Patients , JAMA 189:758, 1964.Crossref 23. Tourtellotte, C.R., and Call, M.K.: Prolonged Remission of Myeloma With Cyclophosphamide , Arch Intern Med 113:758, 1964.Crossref 24. Bergsagel, D.E.; Migliore, P.J.; and Griffith, K.M.: Myeloma Proteins and the Clinical Response to Melphelan Therapy , Science 148:376, 1965.Crossref 25. Osserman, E.F.: Letter to Editor , Science 149:564, 1965.Crossref 26. Lee, B.J.; Korngold, L.; and Weiner, M.F.: Letter to Editor , Science 149:565, 1965.Crossref 27. Tomasi, T.B., Jr.: Human Gamma Globulin , Blood 25:382, 1965. 28. Franklin, E.C., et al: An Unusual Micro-Gamma-Globulin in the Urine and Serum of a Patient , Fed Proc 22:264, 1963. 29. Rowe, D.S., and Fahey, J.L.: A New Class of Human Immunoglobulins , J Exp Med 121:185, 1965.Crossref 30. Braunsteiner, H.: Are Plasma Cells Derived From Lymphocytes? German Medical Monthly 9:469, 1964. 31. Domonkos, A.N.: Personal communication to the authors, March 31, 1965.

Journal

Archives of DermatologyAmerican Medical Association

Published: Apr 1, 1966

References