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Malignant Melanoma of the Head and Neck in Children: Review of the Literature and Report of a Case

Malignant Melanoma of the Head and Neck in Children: Review of the Literature and Report of a Case Abstract • Perusal of the literature revealed that until 1970, 13 children with malignant melanoma of the head and neck had been reported. This group includes two cases of melanoma that developed in a giant cell nevus, as well as one case of congenital melanoma. The biologic features of prepubertal melanoma appear basically analogous to those of the adult variety. Malignant melanoma of the auricle is described in a 2½-year-old child. Surgical therapy was given, and BCG vaccination was used as an adjuvant. The patient is alive and free of signs of the disease 2½ years following the operation. This appears to be the third reported case of malignant melanoma of the external ear in a child. Back to top Article Information Accepted for publication Oct 6, 1975. Reprint requests to the Ichilov Medical Center, Tel Aviv, Israel (Dr Shanon). References 1. Spitz S. Melanomas of childhood. Am J Pathol. 24:591-609, 1948.Google Scholar 2. Allen AC, Spitz S. Malignant melanoma: A clinicopathological analysis of criteria for diagnosis and prognosis. Cancer. 6:1-40, 1953. PubMedGoogle ScholarCrossref 3. Pack GT, Scharnagel IM. Prognosis for malignant melanoma in the pregnant woman. Cancer. 4:324-334, 1951. PubMedGoogle ScholarCrossref 4. Lerman RI, Murray D, O'Hara JM, et al. Malignant melanoma in childhood: A clinicopathologic study and a report of 12 cases. Cancer. 25:436-449, 1970. PubMedGoogle ScholarCrossref 5. Holland JF, Frei E III. Cancer Medicine. Philadelphia, Lea & Febiger Publishers, 1973, pp 1823-1843. 6. Robbins S. Pathologic Basis of Diseases. Philadelphia, WB Saunders Co, 1974, pp 1401-1403. 7. Skov-Jensen, Hastrup J, Lambrethsen S. Malignant melanoma in children. Cancer. 19:620-626, 1966. PubMedGoogle ScholarCrossref 8. Reed WB, Becker SW Sr, Becker SW Jr, et al. Giant pigmented nevi, melanoma and leptomeningeal melanocytosis: A clinical and histopathological study. Arch Dermatol. 91:100-119, 1965. PubMedGoogle ScholarCrossref 9. Conley JJ, Pack GT. Melanoma of the head and neck. Surg Gynecol Obstet. 116:15-28, 1963. PubMedGoogle Scholar 10. Ballantyne AJ. Malignant melanoma of the skin of the head and neck: An analysis of 405 cases. Am J Surg. 120:425-431, 1970. PubMedGoogle ScholarCrossref 11. Daland EM. Malignant melanoma. N Engl J Med. 260:453-460, 1959. PubMedGoogle ScholarCrossref 12. Ward NO, Acquarelli MJ. Malignant melanoma of the external ear. Cancer. 21:226-233, 1968. PubMedGoogle ScholarCrossref 13. Sylven B, Hamberger CA. Malignant melanoma of the external ear. Ann Otol Rhinol Laryngol. 59:631-647, 1950. PubMedGoogle ScholarCrossref 14. Fairley GH. Immunity to malignant disease in man. Br Med J. 2:467-473, 1969. PubMedGoogle ScholarCrossref 15. Morton DL, Eilber FR, Malmgren RA, et al. Immunological factors which influence response to immunotherapy in malignant melanoma. Surgery. 68:158-164, 1970. PubMedGoogle Scholar 16. Adler A, Stein JA, Maor M. Clinical trial of immunotherapy for cancer. Harefuah. 83:513-517, 1972. PubMedGoogle Scholar http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

Malignant Melanoma of the Head and Neck in Children: Review of the Literature and Report of a Case

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Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1976.00780090086015
Publisher site
See Article on Publisher Site

Abstract

Abstract • Perusal of the literature revealed that until 1970, 13 children with malignant melanoma of the head and neck had been reported. This group includes two cases of melanoma that developed in a giant cell nevus, as well as one case of congenital melanoma. The biologic features of prepubertal melanoma appear basically analogous to those of the adult variety. Malignant melanoma of the auricle is described in a 2½-year-old child. Surgical therapy was given, and BCG vaccination was used as an adjuvant. The patient is alive and free of signs of the disease 2½ years following the operation. This appears to be the third reported case of malignant melanoma of the external ear in a child. Back to top Article Information Accepted for publication Oct 6, 1975. Reprint requests to the Ichilov Medical Center, Tel Aviv, Israel (Dr Shanon). References 1. Spitz S. Melanomas of childhood. Am J Pathol. 24:591-609, 1948.Google Scholar 2. Allen AC, Spitz S. Malignant melanoma: A clinicopathological analysis of criteria for diagnosis and prognosis. Cancer. 6:1-40, 1953. PubMedGoogle ScholarCrossref 3. Pack GT, Scharnagel IM. Prognosis for malignant melanoma in the pregnant woman. Cancer. 4:324-334, 1951. PubMedGoogle ScholarCrossref 4. Lerman RI, Murray D, O'Hara JM, et al. Malignant melanoma in childhood: A clinicopathologic study and a report of 12 cases. Cancer. 25:436-449, 1970. PubMedGoogle ScholarCrossref 5. Holland JF, Frei E III. Cancer Medicine. Philadelphia, Lea & Febiger Publishers, 1973, pp 1823-1843. 6. Robbins S. Pathologic Basis of Diseases. Philadelphia, WB Saunders Co, 1974, pp 1401-1403. 7. Skov-Jensen, Hastrup J, Lambrethsen S. Malignant melanoma in children. Cancer. 19:620-626, 1966. PubMedGoogle ScholarCrossref 8. Reed WB, Becker SW Sr, Becker SW Jr, et al. Giant pigmented nevi, melanoma and leptomeningeal melanocytosis: A clinical and histopathological study. Arch Dermatol. 91:100-119, 1965. PubMedGoogle ScholarCrossref 9. Conley JJ, Pack GT. Melanoma of the head and neck. Surg Gynecol Obstet. 116:15-28, 1963. PubMedGoogle Scholar 10. Ballantyne AJ. Malignant melanoma of the skin of the head and neck: An analysis of 405 cases. Am J Surg. 120:425-431, 1970. PubMedGoogle ScholarCrossref 11. Daland EM. Malignant melanoma. N Engl J Med. 260:453-460, 1959. PubMedGoogle ScholarCrossref 12. Ward NO, Acquarelli MJ. Malignant melanoma of the external ear. Cancer. 21:226-233, 1968. PubMedGoogle ScholarCrossref 13. Sylven B, Hamberger CA. Malignant melanoma of the external ear. Ann Otol Rhinol Laryngol. 59:631-647, 1950. PubMedGoogle ScholarCrossref 14. Fairley GH. Immunity to malignant disease in man. Br Med J. 2:467-473, 1969. PubMedGoogle ScholarCrossref 15. Morton DL, Eilber FR, Malmgren RA, et al. Immunological factors which influence response to immunotherapy in malignant melanoma. Surgery. 68:158-164, 1970. PubMedGoogle Scholar 16. Adler A, Stein JA, Maor M. Clinical trial of immunotherapy for cancer. Harefuah. 83:513-517, 1972. PubMedGoogle Scholar

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Apr 1, 1976

Keywords: child,melanoma,head and neck,nevus,surgical procedures, operative,bacille calmette-guerin vaccine,immunologic adjuvants,pharmaceutical adjuvants,external ear,giant cells,pinna

References