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Malignant Hypertension Following Thrombosis of a Renal Artery

Malignant Hypertension Following Thrombosis of a Renal Artery Abstract INTEREST in the hypertensive effect of renal artery stenosis dates back to the work of Katzenstien and of Janway in the early 1900's. However, it was not until some 25 years later that the experiments of Goldblatt established the effect of the ischemic kidney on blood pressure. Additional work by others established a relationship between the ischemic kidney, renin, and angiotensin. Recently angiotensin and renal ischemia have been implicated not only as etiologic factors in hypertension, but in other profound metabolic effects. Several authors have shown that angiotensin is related to the secretion of aldosterone presumably in the normal as well as in pathologic states.1-3 In addition definite effects on renal tubular function have been suggested.3,4 In the past few years an association has been noted between renovascular hypertension (particularly malignant hypertension), hypokalemia, and hyperaldosteronism in patients without primary adrenal pathology.5-11 In approximately half of these cases, References 1. Murlow, P.J., and Ganong, W.F.: Stimulation of Aldosterone Secretion by Angiotensin: IIS. Preliminary Report , Yale J Biol Med 33:386-395, 1961. 2. Laragh, J.H., et al: Hypotensive Agents and Pressor Substances , JAMA 174:234-240, 1960.Crossref 3. Genest, J., et al: Study of a Large Steroid Spectrum in Normal Subjects and Hypertensive Patients , Acta Endocr 35:413-425, 1960. 4. Morris, R.E., Jr.; Robinson, P.R.; and Schelle, G.A.: Relationship of Angiotensin to Renal Hypertension , Canad Med Assoc J 90:272-276, 1964. 5. Rosenheim, M.L., et al: Unilateral Renal Ischemia Due to Compression of a Renal Artery by a Pheochromocytoma , Amer J Med 34:735-740, 1963.Crossref 6. Laidlow, J.C.; Yendt, E.R.; and Gornall, A.G.: Hypertension Caused by Renal Artery Occlusion Simulating Primary Aldosteronism , Metabolism 9: 612-623, 1960. 7. Genest, J., et al: Electrolyte and Corticosteroid Studies in a 15-Year-Old-Girl With Primary Aldosteronism and Malignant Hypertension , Metabolism 9:624-645, 1960. 8. Wrong, O.: Incidence of Hypokalemia in Severe Hypertension , Brit Med J 2:419-421, 1961.Crossref 9. Hilden, T., and Krogseaard, A.R.: Low Serum Potassium Level in Severe Hypertension , Amer J Med Sci 236:487-491, 1958.Crossref 10. Dollery, C.T., et al: Malignant Hypertension and Hypokalemia Cured by Nephrectomy , Brit Med J 2:1367-1369, 1959.Crossref 11. Gowenlock, A.H., and Wrong, O.: Hyperaldosteronism Secondary to Renal Ischemia , Quart J Med 31:323-425, 1960. 12. Yendt, E.R., et al: The Diagnosis and Treatment of Renal Hypertension: With Special Reference to a Case of Hypertension Due to Stenosis of Both Renal Arteries , Amer J Med 28:169-187, 1960.Crossref 13. Howard, J.E.: Hypertension as Related to Renal Ischemia , Circulation 29:657-665, 1964.Crossref 14. Dustan, H., et al: An Evaluation of Treatment of Hypertension Associated With Occlusive Renal Arterial Disease , Circulation 27:1018-1027, 1963.Crossref 15. Howard, J.E.; Berthong, M.; and Yendt, E.R.: Hypertension Resulting From Unilateral Renal Vascular Disease and Its Relief by Nephrectomy , Bull Hopkins Hosp 94:51-85, 1954. 16. Conn, J.W.: Primary Aldosteronism, A New Clinical Entity , Ann Intern Med 44:1-15, 1956.Crossref 17. DeWesselow, L.V.S., and Thomson, W.A.R.: A Study of Some Serum Electrolytes in Hypertension , Quart J Med 8:361-374, 1939. 18. Laragh, J.H.; Cannon, P.J.; and Ames, R.P.: Interaction Between Aldosterone Secretion, Sodium and Potassium Balance and Angiotensin Activity in Man: Studies in Hypertension and Cirrhosis , Canad Med Assoc J 90:248-256, 1964. 19. Laragh, J.H., et al: Aldosterone Secretion and Primary and Malignant Hypertension , J Clin Invest 39:1091-1106, 1960.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Malignant Hypertension Following Thrombosis of a Renal Artery

Archives of Surgery , Volume 93 (6) – Dec 1, 1966

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Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1966.01330060106011
Publisher site
See Article on Publisher Site

Abstract

Abstract INTEREST in the hypertensive effect of renal artery stenosis dates back to the work of Katzenstien and of Janway in the early 1900's. However, it was not until some 25 years later that the experiments of Goldblatt established the effect of the ischemic kidney on blood pressure. Additional work by others established a relationship between the ischemic kidney, renin, and angiotensin. Recently angiotensin and renal ischemia have been implicated not only as etiologic factors in hypertension, but in other profound metabolic effects. Several authors have shown that angiotensin is related to the secretion of aldosterone presumably in the normal as well as in pathologic states.1-3 In addition definite effects on renal tubular function have been suggested.3,4 In the past few years an association has been noted between renovascular hypertension (particularly malignant hypertension), hypokalemia, and hyperaldosteronism in patients without primary adrenal pathology.5-11 In approximately half of these cases, References 1. Murlow, P.J., and Ganong, W.F.: Stimulation of Aldosterone Secretion by Angiotensin: IIS. Preliminary Report , Yale J Biol Med 33:386-395, 1961. 2. Laragh, J.H., et al: Hypotensive Agents and Pressor Substances , JAMA 174:234-240, 1960.Crossref 3. Genest, J., et al: Study of a Large Steroid Spectrum in Normal Subjects and Hypertensive Patients , Acta Endocr 35:413-425, 1960. 4. Morris, R.E., Jr.; Robinson, P.R.; and Schelle, G.A.: Relationship of Angiotensin to Renal Hypertension , Canad Med Assoc J 90:272-276, 1964. 5. Rosenheim, M.L., et al: Unilateral Renal Ischemia Due to Compression of a Renal Artery by a Pheochromocytoma , Amer J Med 34:735-740, 1963.Crossref 6. Laidlow, J.C.; Yendt, E.R.; and Gornall, A.G.: Hypertension Caused by Renal Artery Occlusion Simulating Primary Aldosteronism , Metabolism 9: 612-623, 1960. 7. Genest, J., et al: Electrolyte and Corticosteroid Studies in a 15-Year-Old-Girl With Primary Aldosteronism and Malignant Hypertension , Metabolism 9:624-645, 1960. 8. Wrong, O.: Incidence of Hypokalemia in Severe Hypertension , Brit Med J 2:419-421, 1961.Crossref 9. Hilden, T., and Krogseaard, A.R.: Low Serum Potassium Level in Severe Hypertension , Amer J Med Sci 236:487-491, 1958.Crossref 10. Dollery, C.T., et al: Malignant Hypertension and Hypokalemia Cured by Nephrectomy , Brit Med J 2:1367-1369, 1959.Crossref 11. Gowenlock, A.H., and Wrong, O.: Hyperaldosteronism Secondary to Renal Ischemia , Quart J Med 31:323-425, 1960. 12. Yendt, E.R., et al: The Diagnosis and Treatment of Renal Hypertension: With Special Reference to a Case of Hypertension Due to Stenosis of Both Renal Arteries , Amer J Med 28:169-187, 1960.Crossref 13. Howard, J.E.: Hypertension as Related to Renal Ischemia , Circulation 29:657-665, 1964.Crossref 14. Dustan, H., et al: An Evaluation of Treatment of Hypertension Associated With Occlusive Renal Arterial Disease , Circulation 27:1018-1027, 1963.Crossref 15. Howard, J.E.; Berthong, M.; and Yendt, E.R.: Hypertension Resulting From Unilateral Renal Vascular Disease and Its Relief by Nephrectomy , Bull Hopkins Hosp 94:51-85, 1954. 16. Conn, J.W.: Primary Aldosteronism, A New Clinical Entity , Ann Intern Med 44:1-15, 1956.Crossref 17. DeWesselow, L.V.S., and Thomson, W.A.R.: A Study of Some Serum Electrolytes in Hypertension , Quart J Med 8:361-374, 1939. 18. Laragh, J.H.; Cannon, P.J.; and Ames, R.P.: Interaction Between Aldosterone Secretion, Sodium and Potassium Balance and Angiotensin Activity in Man: Studies in Hypertension and Cirrhosis , Canad Med Assoc J 90:248-256, 1964. 19. Laragh, J.H., et al: Aldosterone Secretion and Primary and Malignant Hypertension , J Clin Invest 39:1091-1106, 1960.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Dec 1, 1966

References