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Malignant Fibrous Histiocytoma of the Orbit

Malignant Fibrous Histiocytoma of the Orbit Abstract • A 31-year-old woman had a mass in the posterior inferior orbit that progressively increased in size for almost two years. Histopathologic examination of an orbital biopsy specimen showed pleomorphic neoplastic cells arranged in a storiform pattern. The tumor cells were composed of hyperchromatic nuclei with prominent nucleoli and admixtures of fibroblasts. Electron microscopy demonstrated histiocyte-like cells with complex infoldings of plasma membrane, prominent mitochondria and golgi, and free ribosomes. Fibroblast-like cells displayed abundant rough endoplasmic reticulum and adjacent collagen fibrils. The diagnosis was malignant fibrous histiocytoma. An exenteration was performed and postoperative systemic chemotherapy with doxorubicin hydrochloride and methotrexate sodium sulfate was commenced. There was no evidence of recurrence two years later. (Arch Ophthalmol 95:2025-2028, 1977) References 1. Delgado-Partida P, Rodriguez-Trujillo F: Fibrosarcoma (malignant fibroxanthoma) involving conjunctiva and ciliary body . Am J Ophthalmol 74:479-485, 1972. 2. Enzinger F, Lattes R, Torloni H: Histological typing of soft tissue tumors , in International Histological Classification of Tumors , no. (3) . Geneva, World Health Organization, 1969. 3. Enzinger FM: Epithelioid sarcoma . Cancer 26:1029-1041, 1970.Crossref 4. Fisher ER, Horvat B: The fibrocytic derivation of the so-called epithelioid sarcoma . Cancer 30:1074-1081, 1972.Crossref 5. Fu Y, Gabbiani G, Kaye G, et al: Malignant soft tissue tumors of probable histiocytic origin (malignant fibrous histiocytomas): General considerations and electron microscopic and tissue culture studies . Cancer 35:176-198, 1975.Crossref 6. Ozello L, Stout AP, Murray M: Cultural characteristics of malignant histiocytomas and fibrous xanthoma . Cancer 16:331-334, 1963.Crossref 7. Jacoby F: Macrophages , in Willmer EN (eds): Cells and Tissues in Culture-Methods Biology and Physiology , vol 2. London, Academic Press, 1965, p 78. 8. Jakobiec FA, Howard GM, Jones IS, et al: Fibrous histiocytomas of the orbit . Am J Ophthalmol 77:333-345, 1974. 9. Vogel M: Fibrous xanthoma of the orbit . Klin Monatsbl Augenheilkd 155:552-558, 1969. 10. Albert D, Smith R: Fibrous xanthoma of the conjunctiva . Arch Ophthalmol 80:474-479, 1968.Crossref 11. Faludi JE, Kenyon K, Green WR: Fibrous histiocytoma of the corneoscleral limbus . Am J Ophthalmol 80:619-624, 1975. 12. Kempson RL, Kyriakos M: Fibroxanthosarcoma of the soft tissues: A type of malignant fibrous histiocytoma . Cancer 29:961-976, 1972.Crossref 13. Soule EH, Enriquez P: Atypical fibrous histiocytoma, malignant histiocytoma and epithelioid sarcoma: A comparative study of 65 tumors . Cancer 30:128-143, 1972.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Malignant Fibrous Histiocytoma of the Orbit

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Publisher
American Medical Association
Copyright
Copyright © 1977 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1977.04450110119014
Publisher site
See Article on Publisher Site

Abstract

Abstract • A 31-year-old woman had a mass in the posterior inferior orbit that progressively increased in size for almost two years. Histopathologic examination of an orbital biopsy specimen showed pleomorphic neoplastic cells arranged in a storiform pattern. The tumor cells were composed of hyperchromatic nuclei with prominent nucleoli and admixtures of fibroblasts. Electron microscopy demonstrated histiocyte-like cells with complex infoldings of plasma membrane, prominent mitochondria and golgi, and free ribosomes. Fibroblast-like cells displayed abundant rough endoplasmic reticulum and adjacent collagen fibrils. The diagnosis was malignant fibrous histiocytoma. An exenteration was performed and postoperative systemic chemotherapy with doxorubicin hydrochloride and methotrexate sodium sulfate was commenced. There was no evidence of recurrence two years later. (Arch Ophthalmol 95:2025-2028, 1977) References 1. Delgado-Partida P, Rodriguez-Trujillo F: Fibrosarcoma (malignant fibroxanthoma) involving conjunctiva and ciliary body . Am J Ophthalmol 74:479-485, 1972. 2. Enzinger F, Lattes R, Torloni H: Histological typing of soft tissue tumors , in International Histological Classification of Tumors , no. (3) . Geneva, World Health Organization, 1969. 3. Enzinger FM: Epithelioid sarcoma . Cancer 26:1029-1041, 1970.Crossref 4. Fisher ER, Horvat B: The fibrocytic derivation of the so-called epithelioid sarcoma . Cancer 30:1074-1081, 1972.Crossref 5. Fu Y, Gabbiani G, Kaye G, et al: Malignant soft tissue tumors of probable histiocytic origin (malignant fibrous histiocytomas): General considerations and electron microscopic and tissue culture studies . Cancer 35:176-198, 1975.Crossref 6. Ozello L, Stout AP, Murray M: Cultural characteristics of malignant histiocytomas and fibrous xanthoma . Cancer 16:331-334, 1963.Crossref 7. Jacoby F: Macrophages , in Willmer EN (eds): Cells and Tissues in Culture-Methods Biology and Physiology , vol 2. London, Academic Press, 1965, p 78. 8. Jakobiec FA, Howard GM, Jones IS, et al: Fibrous histiocytomas of the orbit . Am J Ophthalmol 77:333-345, 1974. 9. Vogel M: Fibrous xanthoma of the orbit . Klin Monatsbl Augenheilkd 155:552-558, 1969. 10. Albert D, Smith R: Fibrous xanthoma of the conjunctiva . Arch Ophthalmol 80:474-479, 1968.Crossref 11. Faludi JE, Kenyon K, Green WR: Fibrous histiocytoma of the corneoscleral limbus . Am J Ophthalmol 80:619-624, 1975. 12. Kempson RL, Kyriakos M: Fibroxanthosarcoma of the soft tissues: A type of malignant fibrous histiocytoma . Cancer 29:961-976, 1972.Crossref 13. Soule EH, Enriquez P: Atypical fibrous histiocytoma, malignant histiocytoma and epithelioid sarcoma: A comparative study of 65 tumors . Cancer 30:128-143, 1972.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Nov 1, 1977

References