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Malathion Exposure Associated With Acute Renal Failure

Malathion Exposure Associated With Acute Renal Failure To the Editor.— Organophosphates, basic ingredients of common garden insecticides, have not been associated with renal toxicity in humans.1,2 We wish to report a case of acute renal insufficiency with massive proteinuria after exposure to the organophosphate malathion. Report of a Case.— A 65-year-old man was admitted to the hospital because of swelling of his legs. Four weeks before admission, he began spraying intensively with malathion and noted intermittent inhalation and skin exposure. Three weeks before admission, he noted an increase in weight and, subsequently, peripheral edema. He had a five-year history of diabetes mellitus treated with insulin. He intermittently took cimetidine for dyspepsia. He denied use of nonsteroidal anti-inflammatory agents. Physical examination disclosed a BP of 150/95 mm Hg, no diabetic retinopathy, gross peripheral edema, and the following values: creatinine, 5.0 mg/dL; serum urea nitrogen, 50 mg/dL; cholesterol, 388 mg/ dL; and albumin, 1.8 g/dL. Urinalysis revealed 4+ http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Malathion Exposure Associated With Acute Renal Failure

Albright, Ronald K.; Kram, Barry W.; White, Robert P.
JAMA , Volume 250 (18) – Nov 11, 1983
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Malathion Exposure Associated With Acute Renal Failure

Abstract



To the Editor.—
Organophosphates, basic ingredients of common garden insecticides, have not been associated with renal toxicity in humans.1,2 We wish to report a case of acute renal insufficiency with massive proteinuria after exposure to the organophosphate malathion.


Report of a Case.—
A 65-year-old man was admitted to the hospital because of swelling of his legs. Four weeks before admission, he began spraying intensively with malathion and noted intermittent inhalation and...
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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1983.03340180031010
Publisher site
See Article on Publisher Site

Abstract

To the Editor.— Organophosphates, basic ingredients of common garden insecticides, have not been associated with renal toxicity in humans.1,2 We wish to report a case of acute renal insufficiency with massive proteinuria after exposure to the organophosphate malathion. Report of a Case.— A 65-year-old man was admitted to the hospital because of swelling of his legs. Four weeks before admission, he began spraying intensively with malathion and noted intermittent inhalation and skin exposure. Three weeks before admission, he noted an increase in weight and, subsequently, peripheral edema. He had a five-year history of diabetes mellitus treated with insulin. He intermittently took cimetidine for dyspepsia. He denied use of nonsteroidal anti-inflammatory agents. Physical examination disclosed a BP of 150/95 mm Hg, no diabetic retinopathy, gross peripheral edema, and the following values: creatinine, 5.0 mg/dL; serum urea nitrogen, 50 mg/dL; cholesterol, 388 mg/ dL; and albumin, 1.8 g/dL. Urinalysis revealed 4+

Journal

JAMA – American Medical Association

Published: Nov 11, 1983

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