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Malabsorption Syndrome, Coccidiosis, Combined Immune Deficiency, and Fulminant Lymphoproliferative Disease

Malabsorption Syndrome, Coccidiosis, Combined Immune Deficiency, and Fulminant... Abstract • Coccidia were found in a patient suffering from malabsorption syndrome. In addition, immunologic investigation showed combined humoral and cellular immunodeficiency. Treatment with metronidazole induced the disappearance of coccidia from the stool and clinical remission. Six months later, the patient was seen with acute lymphoproliferative disease and died thereafter. The possible relationship between malabsorption, immunodeficiency, coccidiosis, metronidazole, and malignancy is reviewed. (Arch Intern Med 1982;142:196-197) References 1. Faust EC, Russell PF, Jung RC: Craig and Faust's Clinical Parasitology , ed 8. Philadelphia, Lea & Febiger, 1970, p 179-183. 2. Jarpa GA: Coccidiosis humana. Biologica 1966;39:3-26. 3. French JM, Whitby JL, Whitefield AGW: Steatorrhea in a man infected with coccidiosis. Gastroenterology 1964;47:642-648. 4. Brandborg LL, Goldberg SB, Bridenbach WC: Human coccidiosis: A possible cause of malabsorption. N Engl J Med 1970;283:1306-1313.Crossref 5. Webster BH: Human isosporiasis: A report of three cases with necropsy findings of one case. Am J Trop Med Hyg 1957;6:86-89. 6. Meisel JL, Perera DR, Meligro C, et al: Overwhelming watery diarrhea associated with a Cryptosporidium in an immunosuppressed patient. Gastroenterology 1976;70:1156-1160. 7. Gewurtz H, Suyelina LA: Complement , in Rose NR, Friedman H (eds): Manual of Clinical Immunology . Washington, DC, American Society for Microbiology, 1976, pp 36-47. 8. Bentwitch Z, Kunkel HG: Specific properties of human B and T lymphocytes and alterations in diseases. Transplant Rev 1973;16:29-50.Crossref 9. Ament ME, Ochs MD, Davis SD: Structure and function of the gastrointestinal tract in primary immunodeficiency syndromes: A study of 39 patients. Medicine 1973;52:227-248.Crossref 10. Henry K, Bird RG, Doe WF: Intestinal coccidiosis in a patient with α-chain disease. Br Med J 1974;1:542-543.Crossref 11. Hermans PE, Huizenga KA, Hoffman HN: Dysgammaglobulinemia associated with nodular lymphoid hyperplasia of the small intestine. Am J Med 1966;40:78-89.Crossref 12. Waldmann TA, Strober W, Blaese RM: Immunodeficiency disease and malignancy. Ann Intern Med 1972;77:605-628.Crossref 13. Gatti RA, Good RA: Occurrence of malignancy in immunodeficiency diseases. Cancer 1971;28:89-98.Crossref 14. Voogd CE, Van Der Stel JJ, Jacobs JJ: The mutagenic action of nitroimidazoles: I. Metronidazole, nimorazole, dimetridazole and ronidazole. Mutat Res 1974;26:483-490.Crossref 15. Legator MS, Connor TH, Stoeckel M: Detection of mutagenic activity of metronidazole and imidazole in body fluids of humans and mice. Science 1975;188:1118-1119.Crossref 16. Rustia M, Shubik P: Induction of lung tumors and malignant lymphomas in mice by metronidazole. J Natl Cancer Inst 1972;48:721-729. 17. Mitelman F, Hartley-Asp B, Ursing B: Chromosome aberrations and metronidazole. Lancet 1976;2:802.Crossref 18. Coxon A, Pallis CA: Metronidazole neuropathy. J Neurol Neurosurg Psychiatry 1976;39:403-405.Crossref 19. Beard CM, Noller KL, O'Fallon WM, et al: Lack of evidence for cancer due to use of metronidazole. N Engl J Med 1979;301:519-522.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Malabsorption Syndrome, Coccidiosis, Combined Immune Deficiency, and Fulminant Lymphoproliferative Disease

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1982.00340140198038
Publisher site
See Article on Publisher Site

Abstract

Abstract • Coccidia were found in a patient suffering from malabsorption syndrome. In addition, immunologic investigation showed combined humoral and cellular immunodeficiency. Treatment with metronidazole induced the disappearance of coccidia from the stool and clinical remission. Six months later, the patient was seen with acute lymphoproliferative disease and died thereafter. The possible relationship between malabsorption, immunodeficiency, coccidiosis, metronidazole, and malignancy is reviewed. (Arch Intern Med 1982;142:196-197) References 1. Faust EC, Russell PF, Jung RC: Craig and Faust's Clinical Parasitology , ed 8. Philadelphia, Lea & Febiger, 1970, p 179-183. 2. Jarpa GA: Coccidiosis humana. Biologica 1966;39:3-26. 3. French JM, Whitby JL, Whitefield AGW: Steatorrhea in a man infected with coccidiosis. Gastroenterology 1964;47:642-648. 4. Brandborg LL, Goldberg SB, Bridenbach WC: Human coccidiosis: A possible cause of malabsorption. N Engl J Med 1970;283:1306-1313.Crossref 5. Webster BH: Human isosporiasis: A report of three cases with necropsy findings of one case. Am J Trop Med Hyg 1957;6:86-89. 6. Meisel JL, Perera DR, Meligro C, et al: Overwhelming watery diarrhea associated with a Cryptosporidium in an immunosuppressed patient. Gastroenterology 1976;70:1156-1160. 7. Gewurtz H, Suyelina LA: Complement , in Rose NR, Friedman H (eds): Manual of Clinical Immunology . Washington, DC, American Society for Microbiology, 1976, pp 36-47. 8. Bentwitch Z, Kunkel HG: Specific properties of human B and T lymphocytes and alterations in diseases. Transplant Rev 1973;16:29-50.Crossref 9. Ament ME, Ochs MD, Davis SD: Structure and function of the gastrointestinal tract in primary immunodeficiency syndromes: A study of 39 patients. Medicine 1973;52:227-248.Crossref 10. Henry K, Bird RG, Doe WF: Intestinal coccidiosis in a patient with α-chain disease. Br Med J 1974;1:542-543.Crossref 11. Hermans PE, Huizenga KA, Hoffman HN: Dysgammaglobulinemia associated with nodular lymphoid hyperplasia of the small intestine. Am J Med 1966;40:78-89.Crossref 12. Waldmann TA, Strober W, Blaese RM: Immunodeficiency disease and malignancy. Ann Intern Med 1972;77:605-628.Crossref 13. Gatti RA, Good RA: Occurrence of malignancy in immunodeficiency diseases. Cancer 1971;28:89-98.Crossref 14. Voogd CE, Van Der Stel JJ, Jacobs JJ: The mutagenic action of nitroimidazoles: I. Metronidazole, nimorazole, dimetridazole and ronidazole. Mutat Res 1974;26:483-490.Crossref 15. Legator MS, Connor TH, Stoeckel M: Detection of mutagenic activity of metronidazole and imidazole in body fluids of humans and mice. Science 1975;188:1118-1119.Crossref 16. Rustia M, Shubik P: Induction of lung tumors and malignant lymphomas in mice by metronidazole. J Natl Cancer Inst 1972;48:721-729. 17. Mitelman F, Hartley-Asp B, Ursing B: Chromosome aberrations and metronidazole. Lancet 1976;2:802.Crossref 18. Coxon A, Pallis CA: Metronidazole neuropathy. J Neurol Neurosurg Psychiatry 1976;39:403-405.Crossref 19. Beard CM, Noller KL, O'Fallon WM, et al: Lack of evidence for cancer due to use of metronidazole. N Engl J Med 1979;301:519-522.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jan 1, 1982

References