Abstract Macroglobulinemia is a rare disease first described by Waldenström,1 in 1948. In North America Long et al.,2 in 1955, reported the first case, and since then a few more have been described.3-7 The disease is of unknown etiology. We studied a patient with macroglobulinemia associated with lymphosarcoma of the brain. The latter was removed, after which the macroglobulins disappeared. Since the case is of unusual interest and throws light on possible relationship between the lymphosarcoma and macroglobulinemia, it is believed to be worthy of report. Report of Case A 63-year-old white woman was first seen at the University Hospital on June 13, 1955, with the chief complaints of weakness, anorexia, palpitation, and weight loss of three years' duration. Since 1954, she was followed by her local physician for anemia unresponsive to vitamin B12, liver extract, and iron. She had received multiple transfusions. She had suffered from typhoid References 1. Waldenström, J.: Zwei interessante Syndrome mit Hyperglobulinämia , Schweiz. med. Wchnschr. 78:927, 1948. 2. Long, L. A.; Riopelle, J. L.; Francoeur, M.; Pare, A.; Poirier, P.; Georgesco, M., and Colpron, G.: Macroglobulinaemia: Effect of Macroglobulins on Prothombin Conversion Acclerators , Canad M.A.J. 73:726, 1955. 3. Voigt, A. E., and Frick, P. G.: Macroglobulinemia of Waldenstrom: A Review of the Literature and Presentation of a Case , Ann. Int. Med. 44:419, 1956.Crossref 4. Glenchur, H.; Zinneman, H. H., and Briggs, D. R.: Macroglobulinemia, Report of 2 Cases , Ann. Int. Med. 48:1055, 1958.Crossref 5. Mackay, J. R.; Erikson, N.; Motulsky, A. G., and Volwiler, W.: Cryo and Macroglobulinemia: Electrophoretic, Ultracentrifugal and Clinical Studies , Am. J. Med. 20:564, 1956.Crossref 6. Jim, R. T. S., and Steinkamp, R. C.: Macroglobulinemia and Its Relationship to Other Paraproteins , J. Lab. & Clin. Med. 47:540, 1956. 7. Hampton, J. W.: Waldenstrom's Macroglobulinemia , New England J. Med. 258:1293, 1958. 8. Bloch, H. S.; Prasad, A., and Anastasi, A.: Serum Protein Changes in Waldenström's Macroglobulinemia During Penicillamine Administration , J. Lab. & Clin. Med. 52:793, 1958. 9. Wilde, H., and Hitzelberger, A. L.: Macroglobulinemia: Clinical Features and Differential Diagnosis , Blood 9:875, 1954. 10. Macroglobulinemia (Editorial) , Brit. M.J. , 1:1475, 1956. 11. Kanzow, U., and Oettgen, H. F.: Beitrag zur Morphologie der Makroglobulinämie Waldenström , Acta haemat. 15:323, 1956. 12. Mackay, I. R.; Taft, L. I., and Woods, E. F.: Clinical Features and Pathogenesis of Macroglobulinemia , Brit. M.J. 1:561, 1957. 13. Abrams, A.; Cohen, P. P., and Meyer, O. O.: The Physical Properties of a Cryoglobulin Obtained from Lymph Nodes and Serum of a Case of Lymphosarcoma , J. Biol. Chem. 181:237, 1949. 14. Braunsteiner, H.; Falkner, R.; Neumayer, A., and Pakesch, F.: Makromolekulare Kryoglobulinämie , Klin. Wchnschr. 32:722, 1954. 15. Dörken, H.: Primäre and sekundäre Purpura hyperglobulinaemic , Acta haemat. 10:340, 1953. 16. Waldenström, J.: Pathological Globulins and Protein Synthesis , Exper. Med. & Surg. 12:187, 1954. 17. Schaub, F.: Gleichzeitiges Vorkommen von Makroglobulinämie Waldenström und von Malignen Tumoren , Schweiz. med. Wchnschr. 83:1256, 1953. 18. Deutsch, H. F., and Morton, J. I.: Dissociation of Human Serum Macroglobulins , Science 125:600, 1957. 19. Bichel, J.; Bing, J., and Harboe, N.: Another Case of Hyperglobulinemia and Affection of the Central Nervous System , Acta med. scandinav. 138:1, 1950.
A.M.A. Archives of Internal Medicine – American Medical Association
Published: Feb 1, 1960
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