Abstract In previous communications1 evidence has been produced to show: (1) that in cases of idiopathic Ménière's syndrome one of two vascular mechanisms is at work, a primary vasodilator and a primary vasoconstrictor mechanism, either of which can produce the characteristic picture; (2) that these two groups can be differentiated by means of an intradermal test with histamine; (3) that the treatment appropriate to one group is inappropriate and in fact deleterious in the other; (4) that therefore accurate grouping is a prime requisite for effective therapy. Further experience has only served to confirm these conclusions. The satisfactory results obtained by desensitization to histamine in the primary vasodilator group have already been published.1b It is gratifying to be able to report that similar results continue to be obtained and that the improvement in the original cases is maintained. This paper is concerned with the method and the results of treatment in References 1. Atkinson, M.: (a) Observations on the Etiology and Treatment of Ménière's Syndrome , J. A. M. A. 116:1753 ( (April 19) ) 1941Crossref 2. Histamine in the Treatment of Ménière's Syndrome: An Appraisal , Atkinson J. A. M. A. 119:4 ( (May 2) ) 1942Crossref 3. Diagnosis and Treatment of Ménière's Syndrome , Arch. Otolaryng. 37:40 ( (Jan.) ) 1943.Crossref 4. The preparation used for the injections, the monoethanolamine salt of nicotinic acid, was supplied for this investigation by Abbott Laboratories, Inc. 5. Mygind, S. H., and Dederding, D.: Les syndromes ménièriques , Paris, Presses Universitaires de France, 1934. 6. Furstenberg, A. C.; Lashmet, F. H., and Lathrop, F.: Ménière Symptom Complex: Medical Treatment , Ann. Otol., Rhin. & Laryng. 43:1035 ( (Dec.) ) 1934. 7. Walsh, M. N., and Adson, A. W.: Méniére's Syndrome: Medical vs. Surgical Treatment , J. A. M. A. 114:130 ( (Jan. 13) ) 1940. 8. Dohlman, G.: Ménièresche Krankheit auf allergischer Basis , Acta oto-laryng. 27:245, 1939.
Archives of Otolaryngology – American Medical Association
Published: Aug 1, 1944