Abstract • In aqueous humor from rabbits with uveitis or after anterior chamber paracentesis, the levels of lysophosphatidyl choline (LPC) were 10.2μg/ml and 14.7μg/ml, respectively. These LPC levels induce early cataractous changes in the rabbit lens in culture. Analysis of the fatty acid composition of LPC showed that saturated fatty acids were more predominant in secondary aqueous humor than in primary aqueous humor. In vitro, natural LPC induced more pronounced gains in sodium ions and water by the lens than similar concentrations of synthetic L-α-lysopalmitoyl phosphatidyl choline. In contrast to prostaglandin E, the levels of LPC in aqueous humor of rabbits with uveitis are cataractogenic. Thus, LPC or its precursors, rather than prostaglandins, are involved in the production of cataracts in uveitis. References 1. Aronson SB, Elliot JH: Ocular Inflammation . St Louis, CV Mosby Co, 1972, pp 41, 61, 152, 225-228, 324-332. 2. Key SN, Kimura SJ: Iridocyclitis associated with juvenile rheumatoid arthritis . Am J Ophthalmol 80:425-429, 1975. 3. Schlaegel TF: Essentials of Uveitis . Boston, Little, Brown and Co, 1970. 4. Kolker AE, Hetherington JJ: Becker-Shaffer's Diagnosis and Therapy of the Glaucomas , ed 3. St Louis, CV Mosby Co, 1970, pp 370-371. 5. Alden ER, Kalina RE, Hodson WA: Transient cataracts in low-birth-weight infants . J Pediatr 82:314-318, 1973.Crossref 6. Pruett RC: Retinitis pigmentosa . Arch Ophthalmol 93:603-608, 1975.Crossref 7. Cotlier E, Baskin M, Kresca L: Effects of lysophosphatidylcholine and phospholipase A on the lens . Invest Ophthalmol 14:697-701, 1975. 8. Folch J, Lees M, Sloan-Stanley GH: A simple method for the isolation and purification of total lipids from animal tissues . J Biol Chem 226:497-509, 1957. 9. Tao RVP, Sweeley CC, Jamieson GA: Sphingolipid composition of human platelets . J Lipid Res 14:16-25, 1973. 10. Bartlett GR: Phosphorous assay in column chromatography . J Biol Chem 234:446-448, 1959. 11. Cotlier E, Kwan B, Beaty C: The lens as osmometer and the effects of medium osmolarity on water transport, 86Rb efflux and 86Rb transport by the lens . Biochim Biophys Acta 150:705-722, 1968.Crossref 12. Kim JO, Cotlier E: Phospholipid distributions and fatty composition of lysophosphatidyl choline and phosphatidyl choline in rabbit aqueous humor, lens, and vitreous. Exp Eye Res, to be published. 13. Varma SD, Reddy UN: Phospholipid composition of aqueous humor, plasma, and lens in normal and alloxan diabetic rabbits . Exp Eye Res 13:120-125, 1972.Crossref 14. Eakins KE: Ocular effects , in Ramwell PW, Shaw JE (eds): The Prostaglandins . New York, Plenum Press, vol 1, 1974. 15. Jaffe BM, Podos SM, Becker B: Indomethacin blocks arachidonic acid-associated elevation of aqueous humor prostaglandin E . Invest Ophthalmol 12:621-622, 1973. 16. Paterson CA, Eck BA: Prostaglandin E, and the ocular lens . Ophthalmic Res 2:246, 1971.Crossref 17. Kellermeyer RW, Graham RC Jr: Kinins: Possible physiologic and pathologic roles in man , N Engl J Med 279:754-759, 802-807, 1968.Crossref 18. Muller-Eberhard HJ: The serum complement system , in Muller-Eberhard HJ, Miescher PA (eds): Textbook of Immunopathology . New York, Grune & Stratton, Inc, 1968. 19. D'Ermo E, Secchi AG, Levi Minzi S, et al: Immunobiologia del criptallino: IV. Studio delle modificazioni della permeabilita del criptellino ai cationi in presenza di unsiero immune anti urea omologa . Boll Oculist 50:83, 1971. 20. Sundmark E: The cataract-inducing effect of systemic corticosteroid therapy . Acta Ophthalmol 44:291-297, 1966.Crossref
Archives of Ophthalmology – American Medical Association
Published: Jul 1, 1976
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