Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Lymphomatoid Papulosis: Histologic and Immunohistochemical Studies in a Patient With a Scaly Pigmented Eruption

Lymphomatoid Papulosis: Histologic and Immunohistochemical Studies in a Patient With a Scaly... Abstract • A patient with lymphomatoid papulosis type A showed a peculiar, scaly pigmented eruption on the broad skin areas as well as papulonodular lesions. Large atypical cells characteristic of the infiltrate of the disease were observed not only in the dermal infiltrate of papular lesions, but also in the perivascular infiltrate of the scaly pigmented lesions, indicating that the latter was one of the skin manifestations of lymphomatoid papulosis. Immunohistochemical studies showed that these atypical cells expressed Ki-1 and cellular activation-associated antigens such as HLA-DR, Tac, and T9, but were not reactive with T-cell specific antibodies Leu-1, Leu-3a, and Leu-2a. (Arch Dermatol 1986;122:1400-1405) References 1. Macaulay WL: Lymphomatoid papulosis: A continuing selfhealing eruption, clinically benign—histologically malignant . Arch Dermatol 1968;97:23-30.Crossref 2. Willemze R, Scheffer E: Clinical and histological differentiation between lymphomatoid papulosis and pityriasis lichenoides . J Am Acad Dermatol 1985;13:418-428.Crossref 3. Sina B, Burnett JW: Lymphomatoid papulosis: Case reports and literature review . Arch Dermatol 1983;119:189-197.Crossref 4. Weinman VF, Ackerman AB: Lymphomatoid papulosis: A critical review and new findings . Am J Dermatol 1981;3:129-163.Crossref 5. Macaulay WL: Lymphomatoid papulosis . Int J Dermatol 1978;17:204-212.Crossref 6. Sanchez NP, Pittelknow MR, Muller SA, et al: The clinicopathological spectrum of lymphomatoid papulosis: Study of 31 cases . J Am Acad Dermatol 1983;8:81-94.Crossref 7. Scheen SR, Doyle JA, Winkelmann RK: Lymphoma-associated papulosis: Lymphomatoid papulosis associated with lymphoma . J Am Acad Dermatol 1981;4:451-457.Crossref 8. Willemze R, Scheffer E, Ruiter DJ, et al: Immunological, cytochemical and ultrastructural studies in lymphomatoid papulosis . Br J Dermatol 1983;108:381-394.Crossref 9. Espinosa CG, Erkman-Balis B, Fenske NA: Lymphomatoid papulosis: A premalignant T cell disorder . J Am Acad Dermatol 1985;13:736-743.Crossref 10. Verallo VVM, Fand SB: DNA measurements in lymphomatoid papulosis: Evidence for this new entity . J Invest Dermatol 1969;53:51-57.Crossref 11. Lange Wantzin G, Thomsen K, Brandrup F, et al: Lymphomatoid papulosis: Development into cutaneous T-cell lymphoma . Arch Dermatol 1985;121:792-794.Crossref 12. Harrist TJ, Bhan AK, Murphy GF, et al: Lymphomatoid papulosis and lymphomatoid granulomatosis: T-cell subset populations, refined light microscopic morphology, and direct immunofluorescence observations , abstracted. J Invest Dermatol 1981; 76:326. 13. Schneiderman P, Edelson R, Lutzner M, et al: Lymphomatoid papulosis: Immunologic and ultrastructural studies, abstracted . J Invest Dermatol 1975;64:209. 14. Black MM, Wilson-Jones E: Lymphomatoid pityriasis lichenoides: A variant with histological features simulating a lymphoma . Br J Dermatol 1972;86:329-347.Crossref 15. Poppema S, van Voorst Vader PC, Rozeboom-Uiterwijk T, et al: Lymphomatoid papulosis: Case report providing evidence for a monocyte-macrophage origin of the atypical cells . Cancer 1983; 52:1178-1182.Crossref 16. Burg G, Hoffmann-Fezer G, Nikolowski J, et al: Lymphomatoid papulosis: A cutaneous T-cell pseudolymphoma . Acta Derm Venereol 1981;61:491-496. 17. Stein H, Mason DY, Gerdes J, et al: The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: Evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells . Blood 1985;66:848-858. 18. Kadin M, Nasu K, Sako D, et al: Lymphomatoid papulosis: A cutaneous proliferation of activated helper T cells expressing Hodgkin's disease-associated antigens . Am J Pathol 1985;119:315-325. 19. Hercend T, Ritz J, Schlossman SF, et al: Comparative expression of T9, T10, and Ia antigens on activated human T cell subsets . Hum Immunol 1981;3:247-259.Crossref 20. Schwab U, Stein H, Gerdes J, et al: Production of a monoclonal antibody specific for Hodgkin's and Sternberg-Reed cells of Hodgkin's disease and a subset of normal lymphoid cells . Nature 1982;299:65-67.Crossref 21. Szur L, Levene GM, Harrison CU, et al: Primary cutaneous Hodgkin's disease . Lancet 1970;1:1016-1020. 22. Brehmer-Andersson E: Lymphomatoid papulosis: A concept which encompasses more than one disease process . Am J Dermatopathol 1981;3:169-174.Crossref 23. Andreesen R, Osterholz J, Lohr GW, et al: A Hodgkin's cell-specific antigen is expressed on a subset of auto- and alloactivated T (helper) lymphoblasts . Blood 1984;63:1299-1302. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Lymphomatoid Papulosis: Histologic and Immunohistochemical Studies in a Patient With a Scaly Pigmented Eruption

Download PDF
6 pages

Loading next page...
 
/lp/american-medical-association/lymphomatoid-papulosis-histologic-and-immunohistochemical-studies-in-a-VnaT95o43x

References (23)

Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1986.01660240064017
Publisher site
See Article on Publisher Site

Abstract

Abstract • A patient with lymphomatoid papulosis type A showed a peculiar, scaly pigmented eruption on the broad skin areas as well as papulonodular lesions. Large atypical cells characteristic of the infiltrate of the disease were observed not only in the dermal infiltrate of papular lesions, but also in the perivascular infiltrate of the scaly pigmented lesions, indicating that the latter was one of the skin manifestations of lymphomatoid papulosis. Immunohistochemical studies showed that these atypical cells expressed Ki-1 and cellular activation-associated antigens such as HLA-DR, Tac, and T9, but were not reactive with T-cell specific antibodies Leu-1, Leu-3a, and Leu-2a. (Arch Dermatol 1986;122:1400-1405) References 1. Macaulay WL: Lymphomatoid papulosis: A continuing selfhealing eruption, clinically benign—histologically malignant . Arch Dermatol 1968;97:23-30.Crossref 2. Willemze R, Scheffer E: Clinical and histological differentiation between lymphomatoid papulosis and pityriasis lichenoides . J Am Acad Dermatol 1985;13:418-428.Crossref 3. Sina B, Burnett JW: Lymphomatoid papulosis: Case reports and literature review . Arch Dermatol 1983;119:189-197.Crossref 4. Weinman VF, Ackerman AB: Lymphomatoid papulosis: A critical review and new findings . Am J Dermatol 1981;3:129-163.Crossref 5. Macaulay WL: Lymphomatoid papulosis . Int J Dermatol 1978;17:204-212.Crossref 6. Sanchez NP, Pittelknow MR, Muller SA, et al: The clinicopathological spectrum of lymphomatoid papulosis: Study of 31 cases . J Am Acad Dermatol 1983;8:81-94.Crossref 7. Scheen SR, Doyle JA, Winkelmann RK: Lymphoma-associated papulosis: Lymphomatoid papulosis associated with lymphoma . J Am Acad Dermatol 1981;4:451-457.Crossref 8. Willemze R, Scheffer E, Ruiter DJ, et al: Immunological, cytochemical and ultrastructural studies in lymphomatoid papulosis . Br J Dermatol 1983;108:381-394.Crossref 9. Espinosa CG, Erkman-Balis B, Fenske NA: Lymphomatoid papulosis: A premalignant T cell disorder . J Am Acad Dermatol 1985;13:736-743.Crossref 10. Verallo VVM, Fand SB: DNA measurements in lymphomatoid papulosis: Evidence for this new entity . J Invest Dermatol 1969;53:51-57.Crossref 11. Lange Wantzin G, Thomsen K, Brandrup F, et al: Lymphomatoid papulosis: Development into cutaneous T-cell lymphoma . Arch Dermatol 1985;121:792-794.Crossref 12. Harrist TJ, Bhan AK, Murphy GF, et al: Lymphomatoid papulosis and lymphomatoid granulomatosis: T-cell subset populations, refined light microscopic morphology, and direct immunofluorescence observations , abstracted. J Invest Dermatol 1981; 76:326. 13. Schneiderman P, Edelson R, Lutzner M, et al: Lymphomatoid papulosis: Immunologic and ultrastructural studies, abstracted . J Invest Dermatol 1975;64:209. 14. Black MM, Wilson-Jones E: Lymphomatoid pityriasis lichenoides: A variant with histological features simulating a lymphoma . Br J Dermatol 1972;86:329-347.Crossref 15. Poppema S, van Voorst Vader PC, Rozeboom-Uiterwijk T, et al: Lymphomatoid papulosis: Case report providing evidence for a monocyte-macrophage origin of the atypical cells . Cancer 1983; 52:1178-1182.Crossref 16. Burg G, Hoffmann-Fezer G, Nikolowski J, et al: Lymphomatoid papulosis: A cutaneous T-cell pseudolymphoma . Acta Derm Venereol 1981;61:491-496. 17. Stein H, Mason DY, Gerdes J, et al: The expression of the Hodgkin's disease associated antigen Ki-1 in reactive and neoplastic lymphoid tissue: Evidence that Reed-Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells . Blood 1985;66:848-858. 18. Kadin M, Nasu K, Sako D, et al: Lymphomatoid papulosis: A cutaneous proliferation of activated helper T cells expressing Hodgkin's disease-associated antigens . Am J Pathol 1985;119:315-325. 19. Hercend T, Ritz J, Schlossman SF, et al: Comparative expression of T9, T10, and Ia antigens on activated human T cell subsets . Hum Immunol 1981;3:247-259.Crossref 20. Schwab U, Stein H, Gerdes J, et al: Production of a monoclonal antibody specific for Hodgkin's and Sternberg-Reed cells of Hodgkin's disease and a subset of normal lymphoid cells . Nature 1982;299:65-67.Crossref 21. Szur L, Levene GM, Harrison CU, et al: Primary cutaneous Hodgkin's disease . Lancet 1970;1:1016-1020. 22. Brehmer-Andersson E: Lymphomatoid papulosis: A concept which encompasses more than one disease process . Am J Dermatopathol 1981;3:169-174.Crossref 23. Andreesen R, Osterholz J, Lohr GW, et al: A Hodgkin's cell-specific antigen is expressed on a subset of auto- and alloactivated T (helper) lymphoblasts . Blood 1984;63:1299-1302.

Journal

Archives of Dermatology – American Medical Association

Published: Dec 1, 1986

There are no references for this article.