Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Lymphocytic Thyroiditis With Spontaneously Resolving Hyperthyroidism and Subacute Thyroiditis: Long-term Follow-up

Lymphocytic Thyroiditis With Spontaneously Resolving Hyperthyroidism and Subacute Thyroiditis:... Abstract In a one- to 15-year follow-up of 124 patients with a history of subacute thyroiditis (SAT) without and with spontaneously resolving hyperthyroidism (SRH) (SAT and SAT-SRH, respectively), only three cases of thyroid disease probably unrelated to the original episode of thyroiditis were found. However, of the 54 patients with a history of lymphocytic thyroiditis (LT) with SRH (LT-SRH), 26 patients were found to have thyroid disease (three with hypothyroidism and 23 with goiters). Antithyroid antibodies were found to be present in 32% (8/25) of the LT-SRH group and in less than 10% (5/60) of the other three groups. The basal thyroid-stimulating hormone levels were substantially increased in the LT-SRH group only, and the response of thyroid-stimulating hormone to 200 μg of protirelin was augmented in both SAT-SRH and LT-SRH groups. These findings demonstrate that SAT and SAT-SRH are transient thyroid diseases rarely leading to permanent thyroid disease, although some loss of thyroid reserve may occur. However, LT-SRH is a persistent progressive disease similar to or the same as chronic LT, in which goiter formation and thyroid failure are a natural course. (Arch Intern Med 1981;141:1455-1458) References 1. Papapetrou PD, Jackson IMD: Thyrotoxicosis due to 'silent' thyroiditis. Lancet 1975;1:361-363.Crossref 2. Hamburger JL: Subacute thyroiditis: Diagnostic difficulties and simple treatment. J Nucl Med 1974;15:81-89. 3. Woolf PD, Daly R: Thyrotoxicosis with painless thyroiditis. Am J Med 1976;60:73-79.Crossref 4. Gluck FB, Nusynowitz ML, Plymate S: Chronic lymphocytic thyroiditis, thyrotoxicosis, and low radioactive iodine uptake. N Engl J Med 1975;293:624-628.Crossref 5. Hofeldt FD, Weled BJ, Brown JE, et al: 'Silent thyroiditis' versus thyrotoxicosis factitia. Minn Med 1976;59:380-382. 6. Nikolai TF, Brosseau J, Kettrick MA, et al: Lymphocytic thyroiditis with spontaneously resolving hyperthyroidism (silent thyroiditis). Arch Intern Med 1980;140:478-482.Crossref 7. Crile G Jr, Rumsey EW: Subacute thyroiditis. JAMA 1950;142:458-462.Crossref 8. Volpe R, Johnston MW, Huber N: Thyroid function in subacute thyroiditis. J Clin Endocrinol Metab 1958;18:65-78.Crossref 9. Furszyfer J, McConahey WM, Wahner HW, et al: Subacute (granulomatous) thyroiditis in Olmsted County, Minnesota. Mayo Clin Proc 1970;45:396-404. 10. Greene JN: Subacute thyroiditis. Am J Med 1971;51:97-108.Crossref 11. Woolner LB, McConahey WM, Beahrs OH: The surgical aspects of thyroiditis. Am J Surg 1962;104:666-671.Crossref 12. Bergen SS Jr: Acute nonsuppurative thyroiditis: A report of 12 cases and a review of the literature. Arch Intern Med 1958;102:747-760.Crossref 13. Inada M, Nishikawa M, Naito K, et al: Correlation of the histological abnormalities of the thyroid with the stage of transient thyrotoxicosis associated with painless thyroiditis, abstract 168 , in Program of the Seventh International Thyroid Congress. Sydney Australia, Australian Academy of Sciences, 1980. 14. Gordin A, Lamberg BA: Natural course of symptomless autoimmune thyroiditis. Lancet 1975;2:1234-1238.Crossref 15. Ginsberg J, Walfish PG: Post-partum transient thyrotoxicosis with painless thyroiditis. Lancet 1977;1:1125-1128.Crossref 16. Gordin A, Lamberg BA: Serum thyrotrophin response to thyrotrophin releasing hormone and the concentration of free thyroxine in subacute thyroiditis. Acta Endocrinol 1973;74:111-121. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Lymphocytic Thyroiditis With Spontaneously Resolving Hyperthyroidism and Subacute Thyroiditis: Long-term Follow-up

Loading next page...
 
/lp/american-medical-association/lymphocytic-thyroiditis-with-spontaneously-resolving-hyperthyroidism-lxrZf42HbQ
Publisher
American Medical Association
Copyright
Copyright © 1981 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1981.00340120063014
Publisher site
See Article on Publisher Site

Abstract

Abstract In a one- to 15-year follow-up of 124 patients with a history of subacute thyroiditis (SAT) without and with spontaneously resolving hyperthyroidism (SRH) (SAT and SAT-SRH, respectively), only three cases of thyroid disease probably unrelated to the original episode of thyroiditis were found. However, of the 54 patients with a history of lymphocytic thyroiditis (LT) with SRH (LT-SRH), 26 patients were found to have thyroid disease (three with hypothyroidism and 23 with goiters). Antithyroid antibodies were found to be present in 32% (8/25) of the LT-SRH group and in less than 10% (5/60) of the other three groups. The basal thyroid-stimulating hormone levels were substantially increased in the LT-SRH group only, and the response of thyroid-stimulating hormone to 200 μg of protirelin was augmented in both SAT-SRH and LT-SRH groups. These findings demonstrate that SAT and SAT-SRH are transient thyroid diseases rarely leading to permanent thyroid disease, although some loss of thyroid reserve may occur. However, LT-SRH is a persistent progressive disease similar to or the same as chronic LT, in which goiter formation and thyroid failure are a natural course. (Arch Intern Med 1981;141:1455-1458) References 1. Papapetrou PD, Jackson IMD: Thyrotoxicosis due to 'silent' thyroiditis. Lancet 1975;1:361-363.Crossref 2. Hamburger JL: Subacute thyroiditis: Diagnostic difficulties and simple treatment. J Nucl Med 1974;15:81-89. 3. Woolf PD, Daly R: Thyrotoxicosis with painless thyroiditis. Am J Med 1976;60:73-79.Crossref 4. Gluck FB, Nusynowitz ML, Plymate S: Chronic lymphocytic thyroiditis, thyrotoxicosis, and low radioactive iodine uptake. N Engl J Med 1975;293:624-628.Crossref 5. Hofeldt FD, Weled BJ, Brown JE, et al: 'Silent thyroiditis' versus thyrotoxicosis factitia. Minn Med 1976;59:380-382. 6. Nikolai TF, Brosseau J, Kettrick MA, et al: Lymphocytic thyroiditis with spontaneously resolving hyperthyroidism (silent thyroiditis). Arch Intern Med 1980;140:478-482.Crossref 7. Crile G Jr, Rumsey EW: Subacute thyroiditis. JAMA 1950;142:458-462.Crossref 8. Volpe R, Johnston MW, Huber N: Thyroid function in subacute thyroiditis. J Clin Endocrinol Metab 1958;18:65-78.Crossref 9. Furszyfer J, McConahey WM, Wahner HW, et al: Subacute (granulomatous) thyroiditis in Olmsted County, Minnesota. Mayo Clin Proc 1970;45:396-404. 10. Greene JN: Subacute thyroiditis. Am J Med 1971;51:97-108.Crossref 11. Woolner LB, McConahey WM, Beahrs OH: The surgical aspects of thyroiditis. Am J Surg 1962;104:666-671.Crossref 12. Bergen SS Jr: Acute nonsuppurative thyroiditis: A report of 12 cases and a review of the literature. Arch Intern Med 1958;102:747-760.Crossref 13. Inada M, Nishikawa M, Naito K, et al: Correlation of the histological abnormalities of the thyroid with the stage of transient thyrotoxicosis associated with painless thyroiditis, abstract 168 , in Program of the Seventh International Thyroid Congress. Sydney Australia, Australian Academy of Sciences, 1980. 14. Gordin A, Lamberg BA: Natural course of symptomless autoimmune thyroiditis. Lancet 1975;2:1234-1238.Crossref 15. Ginsberg J, Walfish PG: Post-partum transient thyrotoxicosis with painless thyroiditis. Lancet 1977;1:1125-1128.Crossref 16. Gordin A, Lamberg BA: Serum thyrotrophin response to thyrotrophin releasing hormone and the concentration of free thyroxine in subacute thyroiditis. Acta Endocrinol 1973;74:111-121.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Oct 1, 1981

References