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Lutein + Zeaxanthin and Omega-3 Fatty Acids for Age-Related Macular Degeneration

Lutein + Zeaxanthin and Omega-3 Fatty Acids for Age-Related Macular Degeneration ORIGINAL CONTRIBUTION ONLINE FIRST LuteinZeaxanthin and Omega-3 Fatty Acids for Age-Related Macular Degeneration The Age-Related Eye Disease Study 2 (AREDS2) Randomized Clinical Trial The Age-Related Eye Disease Study 2 Importance Oral supplementation with the Age-Related Eye Disease Study (AREDS) (AREDS2) Research Group* formulation (antioxidant vitamins C and E, beta carotene, and zinc) has been shown to reduce the risk of progression to advanced age-related macular degeneration (AMD). GE-RELATED MACULAR DEGEN- Observational data suggest that increased dietary intake of luteinzeaxanthin eration (AMD), the leading (carotenoids), omega-3 long-chain polyunsaturated fatty acids (docosahexaenoic acid [DHA]eicosapentaenoic acid [EPA]), or both might further reduce this risk. cause of blindness in the de- Aveloped world, accounts for Objectives To determine whether adding luteinzeaxanthin, DHAEPA, or both to the AREDS formulation decreases the risk of developing advanced AMD and to evalu- more than 50% of all blindness in the ate the effect of eliminating beta carotene, lowering zinc doses, or both in the AREDS United States. In 2004, it was esti- formulation. mated that 8 million individuals had in- Design, Setting, and Participants The Age-Related Eye Disease Study 2 (AREDS2), termediate AMD, defined as bilateral a multicenter, randomized, double-masked, placebo-controlled phase 3 study with a drusen, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Lutein + Zeaxanthin and Omega-3 Fatty Acids for Age-Related Macular Degeneration

JAMA , Volume 309 (19) – May 15, 2013

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Publisher
American Medical Association
Copyright
Copyright 2013 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2013.4997
pmid
23644932
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION ONLINE FIRST LuteinZeaxanthin and Omega-3 Fatty Acids for Age-Related Macular Degeneration The Age-Related Eye Disease Study 2 (AREDS2) Randomized Clinical Trial The Age-Related Eye Disease Study 2 Importance Oral supplementation with the Age-Related Eye Disease Study (AREDS) (AREDS2) Research Group* formulation (antioxidant vitamins C and E, beta carotene, and zinc) has been shown to reduce the risk of progression to advanced age-related macular degeneration (AMD). GE-RELATED MACULAR DEGEN- Observational data suggest that increased dietary intake of luteinzeaxanthin eration (AMD), the leading (carotenoids), omega-3 long-chain polyunsaturated fatty acids (docosahexaenoic acid [DHA]eicosapentaenoic acid [EPA]), or both might further reduce this risk. cause of blindness in the de- Aveloped world, accounts for Objectives To determine whether adding luteinzeaxanthin, DHAEPA, or both to the AREDS formulation decreases the risk of developing advanced AMD and to evalu- more than 50% of all blindness in the ate the effect of eliminating beta carotene, lowering zinc doses, or both in the AREDS United States. In 2004, it was esti- formulation. mated that 8 million individuals had in- Design, Setting, and Participants The Age-Related Eye Disease Study 2 (AREDS2), termediate AMD, defined as bilateral a multicenter, randomized, double-masked, placebo-controlled phase 3 study with a drusen,

Journal

JAMAAmerican Medical Association

Published: May 15, 2013

References

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