ORIGINAL CONTRIBUTION ONLINE FIRST LuteinZeaxanthin and Omega-3 Fatty Acids for Age-Related Macular Degeneration The Age-Related Eye Disease Study 2 (AREDS2) Randomized Clinical Trial The Age-Related Eye Disease Study 2 Importance Oral supplementation with the Age-Related Eye Disease Study (AREDS) (AREDS2) Research Group* formulation (antioxidant vitamins C and E, beta carotene, and zinc) has been shown to reduce the risk of progression to advanced age-related macular degeneration (AMD). GE-RELATED MACULAR DEGEN- Observational data suggest that increased dietary intake of luteinzeaxanthin eration (AMD), the leading (carotenoids), omega-3 long-chain polyunsaturated fatty acids (docosahexaenoic acid [DHA]eicosapentaenoic acid [EPA]), or both might further reduce this risk. cause of blindness in the de- Aveloped world, accounts for Objectives To determine whether adding luteinzeaxanthin, DHAEPA, or both to the AREDS formulation decreases the risk of developing advanced AMD and to evalu- more than 50% of all blindness in the ate the effect of eliminating beta carotene, lowering zinc doses, or both in the AREDS United States. In 2004, it was esti- formulation. mated that 8 million individuals had in- Design, Setting, and Participants The Age-Related Eye Disease Study 2 (AREDS2), termediate AMD, defined as bilateral a multicenter, randomized, double-masked, placebo-controlled phase 3 study with a drusen,
JAMA – American Medical Association
Published: May 15, 2013
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