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Low Serum Iron Levels and Moderate Anemia in Severe Nodulocystic Acne: Reversal With Isotretinoin Therapy

Low Serum Iron Levels and Moderate Anemia in Severe Nodulocystic Acne: Reversal With Isotretinoin... Abstract • Moderate anemia was present in 25% and low serum iron levels in 75% of patients with severe nodulocystic acne. These findings, combined with an elevated serum ferritin level and normal transferrin saturation, indicate that the low serum iron levels and anemia are secondary to the chronic disease state of cutaneous inflammation rather than an iron-deficiency state. Successful therapy of the severe cystic acne with isotretinoin (13-cis-retinoic acid) resulted in return of serum iron and hemoglobin values to normal levels and a decrease in serum ferritin level. (Arch Dermatol 1985;121:214-215) References 1. Plewig G, Wagner A, Nikolowski J, et al: Effects of two retinoids in animal experiments and after clinical application in acne patients , in Orfanos CE, Braum-Falco O, Farber EM, et al (eds): Retinoids . New York, Springer Publishing Co Inc, 1981, pp 219-235. 2. Finch CA, Huebers H: Perspective in iron metabolism . N Engl J Med 1982;306:1520-1528.Crossref 3. Worwood M, Serum ferritin , in Jacobs A, Worwood M (eds): Iron in Biochemistry and Medicine , II. New York, Academic Press Inc, 1980, pp 203-244. 4. Lipschitz DA, Cook JD, Finch CA: A clinical evaluation of serum ferritin as an index of iron stores . N Engl J Med 1974;290:1213-1216.Crossref 5. Finch CA, Deubelbeiss K, Cook JD, et al: Ferrokinetics in man . Medicine 1979;49:17-53. 6. Cartwright GE: The anemia of chronic disorders . Semin Hematol 1966;3:351-375. 7. Cook JD, Hershko C, Finch CA: Storage iron kinetics: V. Iron exchange in the rat . Br J Haematol 1973;25:695-706.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Low Serum Iron Levels and Moderate Anemia in Severe Nodulocystic Acne: Reversal With Isotretinoin Therapy

Archives of Dermatology , Volume 121 (2) – Feb 1, 1985

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Publisher
American Medical Association
Copyright
Copyright © 1985 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1985.01660020072020
Publisher site
See Article on Publisher Site

Abstract

Abstract • Moderate anemia was present in 25% and low serum iron levels in 75% of patients with severe nodulocystic acne. These findings, combined with an elevated serum ferritin level and normal transferrin saturation, indicate that the low serum iron levels and anemia are secondary to the chronic disease state of cutaneous inflammation rather than an iron-deficiency state. Successful therapy of the severe cystic acne with isotretinoin (13-cis-retinoic acid) resulted in return of serum iron and hemoglobin values to normal levels and a decrease in serum ferritin level. (Arch Dermatol 1985;121:214-215) References 1. Plewig G, Wagner A, Nikolowski J, et al: Effects of two retinoids in animal experiments and after clinical application in acne patients , in Orfanos CE, Braum-Falco O, Farber EM, et al (eds): Retinoids . New York, Springer Publishing Co Inc, 1981, pp 219-235. 2. Finch CA, Huebers H: Perspective in iron metabolism . N Engl J Med 1982;306:1520-1528.Crossref 3. Worwood M, Serum ferritin , in Jacobs A, Worwood M (eds): Iron in Biochemistry and Medicine , II. New York, Academic Press Inc, 1980, pp 203-244. 4. Lipschitz DA, Cook JD, Finch CA: A clinical evaluation of serum ferritin as an index of iron stores . N Engl J Med 1974;290:1213-1216.Crossref 5. Finch CA, Deubelbeiss K, Cook JD, et al: Ferrokinetics in man . Medicine 1979;49:17-53. 6. Cartwright GE: The anemia of chronic disorders . Semin Hematol 1966;3:351-375. 7. Cook JD, Hershko C, Finch CA: Storage iron kinetics: V. Iron exchange in the rat . Br J Haematol 1973;25:695-706.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Feb 1, 1985

References