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Low Heritability of Tinnitus

Low Heritability of Tinnitus ORIGINAL ARTICLE Results From the Second Nord-Trøndelag Health Study Ellen Kvestad, MD, PhD; Nikolai Czajkowski, MS, MA; Bo Engdahl, PhD; Howard J. Hoffman, MA; Kristian Tambs, PhD Objective: To estimate the heritability of tinnitus. total of 28 066 respondents were tested twice, yielding a test-retest correlation of 0.65 for the report of tinnitus. Design: Self-report questionnaire data collected from Au- Main Outcome Measure: Heritability of tinnitus. gust 1, 1995, through June 30, 1997, from individuals in the Nord-Trøndelag Hearing Loss Study (an inte- Results: Correlations for parent-offspring ranged from grated part of the Nord-Trøndelag Health Study) were 0.01 to 0.07 for the various sex combinations, sibling cor- used. The study also included information on first- relation ranged from 0.06 to 0.14, and the spouse cor- degree family relationships, and age-corrected poly- relation was 0.04. This family correlation pattern im- choric correlations of relatives’ tinnitus status were cal- plies an upper limit for heritability of 0.11 with no sex culated. A structural equation model was fit to the data, differences in the heritability estimates. and the relative contributions of genes and unique en- vironmental effects were estimated. Models that in- Conclusions: This is the first large population-based fam- cluded sex-specific http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Otolaryngology - Head & Neck Surgery American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6181
eISSN
2168-619X
DOI
10.1001/archoto.2009.220
pmid
20157066
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Results From the Second Nord-Trøndelag Health Study Ellen Kvestad, MD, PhD; Nikolai Czajkowski, MS, MA; Bo Engdahl, PhD; Howard J. Hoffman, MA; Kristian Tambs, PhD Objective: To estimate the heritability of tinnitus. total of 28 066 respondents were tested twice, yielding a test-retest correlation of 0.65 for the report of tinnitus. Design: Self-report questionnaire data collected from Au- Main Outcome Measure: Heritability of tinnitus. gust 1, 1995, through June 30, 1997, from individuals in the Nord-Trøndelag Hearing Loss Study (an inte- Results: Correlations for parent-offspring ranged from grated part of the Nord-Trøndelag Health Study) were 0.01 to 0.07 for the various sex combinations, sibling cor- used. The study also included information on first- relation ranged from 0.06 to 0.14, and the spouse cor- degree family relationships, and age-corrected poly- relation was 0.04. This family correlation pattern im- choric correlations of relatives’ tinnitus status were cal- plies an upper limit for heritability of 0.11 with no sex culated. A structural equation model was fit to the data, differences in the heritability estimates. and the relative contributions of genes and unique en- vironmental effects were estimated. Models that in- Conclusions: This is the first large population-based fam- cluded sex-specific

Journal

JAMA Otolaryngology - Head & Neck SurgeryAmerican Medical Association

Published: Feb 1, 2010

References