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Lou Gehrig and Amyotrophic Lateral Sclerosis: Is Vitamin E to Be Revisited?

Lou Gehrig and Amyotrophic Lateral Sclerosis: Is Vitamin E to Be Revisited? Abstract Investigators are beginning to reexamine the use of vitamin E for the treatment of amyotrophic lateral sclerosis. Vitamin E was isolated in the 1920s, and the results of animal studies led rapidly to clinical use. Regrettably, vitamin E did not ameliorate the progression of amyotrophic lateral sclerosis for Lou Gehrig, but more recent advances may identify subpopulations that do respond to vitamin E. References 1. Siddique T, Hentati A. Familial motor neuron disease . In: Appel SH, ed. Current Neurology . St Louis, Mo: Mosby—Year Book Inc; 1996:281-300. 2. Robberecht W. New treatment strategies in amyotrophic lateral sclerosis: solutions or illusions? Acta Neurol Belg . 1995;95:65-69. 3. Parkinson Study Group. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease . N Engl J Med . 1993;328:176-183.Crossref 4. Mason KE. Physiological action of vitamin E and its homologs . In: Harris RS, Thimann KV, eds. Vitamins and Hormones: Advances in Research and Application . New York, NY: Academic Press; 1944:129-153. 5. Kasarskis EJ, Winslow M. When did Lou Gehrig's personal illness begin? Neurology . 1989;39:1243-1245.Crossref 6. Robinson R. Iron Horse Lou Gehrig in His Time . New York, NY: WW Norton & Co Inc; 1990:258. 7. Shamo MA, Kyle RA. Lou Gehrig: amyotrophic lateral sclerosis . Mayo Clinic Proc . 1993;68:929.Crossref 8. Jolliffe N, Most RM. Appraisal of nutritional status . In: Harris RS, Thimann KV, eds. Vitamins and Hormones: Advances in Research and Application . New York, NY: Academic Press; 1943:96-97. 9. Wechsler IS. Recovery in amyotrophic lateral sclerosis . Neurology . 1940;114:948-950. 10. Wechsler IS. The treatment of amyotrophic lateral sclerosis with vitamin E (tocopherols) . Am J Med Sci . 1940;200:765-778.Crossref 11. Dorman JD, Engel WK, Fried DM. Therapeutic trial in amyotrophic lateral sclerosis . JAMA . 1969;209:257-258.Crossref 12. Bieri JG, Corash L, Hubbard VS. Medical uses of vitamin E . N Engl J Med . 1983;308:1063-1071.Crossref 13. Rosen DR, Siddique T, Patterson D, et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis . Nature . 1993;362:59-62.Crossref 14. Orrell RW, Habgood J, Rudge P, et al. Difficulties in distinguishing sporadic from familial amyotrophic lateral sclerosis . Ann Neurol . 1996;39:810-812.Crossref 15. Sendtner M, Thoenen H. Oxidative stress and motorneuron disease . Curr Biol . 1994;4:1036-1039.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Lou Gehrig and Amyotrophic Lateral Sclerosis: Is Vitamin E to Be Revisited?

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Publisher
American Medical Association
Copyright
Copyright © 1997 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1997.00550170013008
Publisher site
See Article on Publisher Site

Abstract

Abstract Investigators are beginning to reexamine the use of vitamin E for the treatment of amyotrophic lateral sclerosis. Vitamin E was isolated in the 1920s, and the results of animal studies led rapidly to clinical use. Regrettably, vitamin E did not ameliorate the progression of amyotrophic lateral sclerosis for Lou Gehrig, but more recent advances may identify subpopulations that do respond to vitamin E. References 1. Siddique T, Hentati A. Familial motor neuron disease . In: Appel SH, ed. Current Neurology . St Louis, Mo: Mosby—Year Book Inc; 1996:281-300. 2. Robberecht W. New treatment strategies in amyotrophic lateral sclerosis: solutions or illusions? Acta Neurol Belg . 1995;95:65-69. 3. Parkinson Study Group. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease . N Engl J Med . 1993;328:176-183.Crossref 4. Mason KE. Physiological action of vitamin E and its homologs . In: Harris RS, Thimann KV, eds. Vitamins and Hormones: Advances in Research and Application . New York, NY: Academic Press; 1944:129-153. 5. Kasarskis EJ, Winslow M. When did Lou Gehrig's personal illness begin? Neurology . 1989;39:1243-1245.Crossref 6. Robinson R. Iron Horse Lou Gehrig in His Time . New York, NY: WW Norton & Co Inc; 1990:258. 7. Shamo MA, Kyle RA. Lou Gehrig: amyotrophic lateral sclerosis . Mayo Clinic Proc . 1993;68:929.Crossref 8. Jolliffe N, Most RM. Appraisal of nutritional status . In: Harris RS, Thimann KV, eds. Vitamins and Hormones: Advances in Research and Application . New York, NY: Academic Press; 1943:96-97. 9. Wechsler IS. Recovery in amyotrophic lateral sclerosis . Neurology . 1940;114:948-950. 10. Wechsler IS. The treatment of amyotrophic lateral sclerosis with vitamin E (tocopherols) . Am J Med Sci . 1940;200:765-778.Crossref 11. Dorman JD, Engel WK, Fried DM. Therapeutic trial in amyotrophic lateral sclerosis . JAMA . 1969;209:257-258.Crossref 12. Bieri JG, Corash L, Hubbard VS. Medical uses of vitamin E . N Engl J Med . 1983;308:1063-1071.Crossref 13. Rosen DR, Siddique T, Patterson D, et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis . Nature . 1993;362:59-62.Crossref 14. Orrell RW, Habgood J, Rudge P, et al. Difficulties in distinguishing sporadic from familial amyotrophic lateral sclerosis . Ann Neurol . 1996;39:810-812.Crossref 15. Sendtner M, Thoenen H. Oxidative stress and motorneuron disease . Curr Biol . 1994;4:1036-1039.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: May 1, 1997

References