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Lorazepam in the Treatment of Refractory Neonatal Seizures: A Pilot Study

Lorazepam in the Treatment of Refractory Neonatal Seizures: A Pilot Study Abstract • Seven neonatal patients with severe seizures unresponsive to conventional anticonvulsant therapy were treated with lorazepam. Immediate cessation of seizure activity occurred in all patients within five minutes. Although seizures recurred in two infants eight hours later, frequency and severity diminished. There were no apparent significant side effects attributed to the medication. (AJDC 1986;140:1042-1044) References 1. Fenichel GM: Neonatal Neurology . New York, Churchill Livingstone Inc, 1980, chap 2 . 2. Volpe JJ: Neurology of the Newborn . Philadelphia, WB Saunders Co, 1981, chap 5 . 3. Leppik IE, Derivan AT, Homan RW, et al: Double-blind study of lorazepam and diazepam in status epilepticus . JAMA 1983;249:1452-1454.Crossref 4. Levy RJ, Krall RL: Treatment of status epilepticus with lorazepam . Arch Neurol 1984;41:605-611.Crossref 5. Howman RW, Walker JE: Clinical studies of lorazepam in status epilepticus . Adv Neurol 1983;34:493-498. 6. Painter MJ, Pippenger C, MacDonald H, et al: Phenobarbital and diphenylhydantoin levels in neonates with seizures . J Pediatr 1978:92:315-319 7. Greenblatt DJ, Comer WH, Elliott HW, et al: Clinical pharmacokinetics of lorazepam: III. Intravenous injection: Preliminary results . J Clin Pharmacol 1977;17:490-494.Crossref 8. Greenblatt DJ, Shader RI, Franke K, et al: Pharmacokinetics and bioavailability of intravenous, intramuscular, and oral lorazepam in humans . J Pharm Sci 1979;68:57-63.Crossref 9. Glasgow AM, Boeckx RL, Miller MK, et al: Hyperosmolality in small infants due to propylene glycol . Pediatrics 1983;72:353-355. 10. Brown WJ, Buist NRM, Gipson HTC, et al: Fatal benzyl alcohol poisoning in a neonatal intensive care unit . Lancet 1982;1:1250.Crossref 11. Gershanik JJ, Boeder B, George W, et al: The gasping syndrome: Benzyl alcohol (BA) poisoning? abstracted. Clin Res 1981;29:895A. 12. Brodersen R: Free bilirubin in blood plasma of the newborn: Effects of albumin, fatty acids, pH, displacing drugs, and phototherapy , in Stern L, Oh W, Friis-Hansen B (eds): Intensive Care of the Newborn: II . New York, Masson Publishers USA Inc, 1978, pp 331-345. 13. Greenblatt DJ, Shader RI: Drug therapy: Prazepam and lorazepam, two new benzodiazepines . N Engl J Med 1978;299:1342-1344.Crossref 14. Werner SS, Stockard JE, Bickferd RG: Atlas of Neonatal Electroencephalography . New York, Raven Press, 1977, p 19. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Lorazepam in the Treatment of Refractory Neonatal Seizures: A Pilot Study

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Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1986.02140240088032
Publisher site
See Article on Publisher Site

Abstract

Abstract • Seven neonatal patients with severe seizures unresponsive to conventional anticonvulsant therapy were treated with lorazepam. Immediate cessation of seizure activity occurred in all patients within five minutes. Although seizures recurred in two infants eight hours later, frequency and severity diminished. There were no apparent significant side effects attributed to the medication. (AJDC 1986;140:1042-1044) References 1. Fenichel GM: Neonatal Neurology . New York, Churchill Livingstone Inc, 1980, chap 2 . 2. Volpe JJ: Neurology of the Newborn . Philadelphia, WB Saunders Co, 1981, chap 5 . 3. Leppik IE, Derivan AT, Homan RW, et al: Double-blind study of lorazepam and diazepam in status epilepticus . JAMA 1983;249:1452-1454.Crossref 4. Levy RJ, Krall RL: Treatment of status epilepticus with lorazepam . Arch Neurol 1984;41:605-611.Crossref 5. Howman RW, Walker JE: Clinical studies of lorazepam in status epilepticus . Adv Neurol 1983;34:493-498. 6. Painter MJ, Pippenger C, MacDonald H, et al: Phenobarbital and diphenylhydantoin levels in neonates with seizures . J Pediatr 1978:92:315-319 7. Greenblatt DJ, Comer WH, Elliott HW, et al: Clinical pharmacokinetics of lorazepam: III. Intravenous injection: Preliminary results . J Clin Pharmacol 1977;17:490-494.Crossref 8. Greenblatt DJ, Shader RI, Franke K, et al: Pharmacokinetics and bioavailability of intravenous, intramuscular, and oral lorazepam in humans . J Pharm Sci 1979;68:57-63.Crossref 9. Glasgow AM, Boeckx RL, Miller MK, et al: Hyperosmolality in small infants due to propylene glycol . Pediatrics 1983;72:353-355. 10. Brown WJ, Buist NRM, Gipson HTC, et al: Fatal benzyl alcohol poisoning in a neonatal intensive care unit . Lancet 1982;1:1250.Crossref 11. Gershanik JJ, Boeder B, George W, et al: The gasping syndrome: Benzyl alcohol (BA) poisoning? abstracted. Clin Res 1981;29:895A. 12. Brodersen R: Free bilirubin in blood plasma of the newborn: Effects of albumin, fatty acids, pH, displacing drugs, and phototherapy , in Stern L, Oh W, Friis-Hansen B (eds): Intensive Care of the Newborn: II . New York, Masson Publishers USA Inc, 1978, pp 331-345. 13. Greenblatt DJ, Shader RI: Drug therapy: Prazepam and lorazepam, two new benzodiazepines . N Engl J Med 1978;299:1342-1344.Crossref 14. Werner SS, Stockard JE, Bickferd RG: Atlas of Neonatal Electroencephalography . New York, Raven Press, 1977, p 19.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Oct 1, 1986

References