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Longitudinal Growth in Thalassemia Major: Relationship to Hemoglobin Level

Longitudinal Growth in Thalassemia Major: Relationship to Hemoglobin Level Abstract IN A PREVIOUS study1 of the growth patterns of children with thalassemia major (Cooley's anemia)2 it was noted that affected individuals suffered alterations of their developmental courses in terms of size attained at any one age, as well as the rate of maturation. Significant size retardations were observed in stature, sitting height, weight, biacromial (shoulder) and bicristal (iliac crest) breadths. In addition, maturation rates, as estimated from skeletal age assessments,3 were also retarded. However, even when this slowed rate of maturation was removed as a factor, size deficiencies were noted in all but bicristal breadth, although these deficiencies were less. Thus it appears that there are retardations of both amount of growth and maturation rate in thalassemia. The size retardations are partially the result of growth failures, partially of slower maturation rates (fast-growing children are almost invariably larger than slow-growers). In spite of the clear-cut nature of References 1. Johnston, F.E., and Krogman, W.M.: Patterns of Growth in Children With Thalassemia Major , Ann NY Acad Sci 119:667-679, 1964.Crossref 2. Fink, H.E. (ed.): Problems of Cooley's Anemia , Ann NY Acad Sci 119:369-850. 3. Greulick, W.W., and Pyle, S.I.: Radiographic Atlas of Skeletal Development of the Hand and Wrist , ed 2, Stanford, Calif: Stanford University Press, 1959. 4. Wolman, I.W.: Transfusion Therapy in Cooley's Anemia: Growth and Health as Related to Long-Range Hemoglobin Levels: A Progress Report , Ann NY Acad Sci 119:736-747, 1964.Crossref 5. Tanner, J.M.: Growth at Adolescence , ed 2, Oxford, England: Oxford University Press, 1962. 6. Tanner, J.M.: "The Evaluation of Growth and Maturity in Children," in Gross, F. (ed.): Protein Metabolism , Berlin: Springer-Verlag, 1962. 7. Tate, M.W.: Statistics in Education , New York: Macmillan Co., Publishers, 1955. 8. Kosowicz, J.: The Roentgen Appearance of the Head and Wrist in Gonadal Dysgenesis , Amer J Roentgen 93:354-361, 1965. 9. Fink, H.E.: Transfusion Hemachromatosis in Cooley's Anemia , Ann NY Acad Sci 119:680-685,1964.Crossref 10. Smith, R.S.: Iron Deficiency and Iron Overload , Arch Dis Child 40:343-363, 1965.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Longitudinal Growth in Thalassemia Major: Relationship to Hemoglobin Level

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Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1966.02090140068003
Publisher site
See Article on Publisher Site

Abstract

Abstract IN A PREVIOUS study1 of the growth patterns of children with thalassemia major (Cooley's anemia)2 it was noted that affected individuals suffered alterations of their developmental courses in terms of size attained at any one age, as well as the rate of maturation. Significant size retardations were observed in stature, sitting height, weight, biacromial (shoulder) and bicristal (iliac crest) breadths. In addition, maturation rates, as estimated from skeletal age assessments,3 were also retarded. However, even when this slowed rate of maturation was removed as a factor, size deficiencies were noted in all but bicristal breadth, although these deficiencies were less. Thus it appears that there are retardations of both amount of growth and maturation rate in thalassemia. The size retardations are partially the result of growth failures, partially of slower maturation rates (fast-growing children are almost invariably larger than slow-growers). In spite of the clear-cut nature of References 1. Johnston, F.E., and Krogman, W.M.: Patterns of Growth in Children With Thalassemia Major , Ann NY Acad Sci 119:667-679, 1964.Crossref 2. Fink, H.E. (ed.): Problems of Cooley's Anemia , Ann NY Acad Sci 119:369-850. 3. Greulick, W.W., and Pyle, S.I.: Radiographic Atlas of Skeletal Development of the Hand and Wrist , ed 2, Stanford, Calif: Stanford University Press, 1959. 4. Wolman, I.W.: Transfusion Therapy in Cooley's Anemia: Growth and Health as Related to Long-Range Hemoglobin Levels: A Progress Report , Ann NY Acad Sci 119:736-747, 1964.Crossref 5. Tanner, J.M.: Growth at Adolescence , ed 2, Oxford, England: Oxford University Press, 1962. 6. Tanner, J.M.: "The Evaluation of Growth and Maturity in Children," in Gross, F. (ed.): Protein Metabolism , Berlin: Springer-Verlag, 1962. 7. Tate, M.W.: Statistics in Education , New York: Macmillan Co., Publishers, 1955. 8. Kosowicz, J.: The Roentgen Appearance of the Head and Wrist in Gonadal Dysgenesis , Amer J Roentgen 93:354-361, 1965. 9. Fink, H.E.: Transfusion Hemachromatosis in Cooley's Anemia , Ann NY Acad Sci 119:680-685,1964.Crossref 10. Smith, R.S.: Iron Deficiency and Iron Overload , Arch Dis Child 40:343-363, 1965.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Nov 1, 1966

References