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Opinion EDITORIAL Long-term Outcomes of Children After Fetal Surgery for Spina Bifida—Toward Sustainability Martin Meuli, MD; Ueli Moehrlen, MD The study by Houtrow et al is an eagerly awaited new chap- more importantly, whether they would be consistent over time— ter of an intriguing story that began almost 70 years ago. here, definitive answers are pending (U. Moehrlen, MD, written communication, 2020). In 1956, Cameron published a Lancet article to describe al- legedly secondary tissue damage of the openly exposed spi- The work published here by Houtrow and colleagues is one nal cord tissue of fetuses and of the National Institutes of Health–sponsored follow-up stud- newborn babies with spina bi- ies after the original MOMS trial (MOMS2). It presents world- Related article fida (SB) aperta (ie, myelome- wide, first-time evidence that motor spinal levels and, conse- ningocele or myeloschisis). The lesion was characterized by quently, functional mobility are better in school-aged patients neural tissue damage that was apparently acquired in utero or with a history of prenatal rather than postnatal SB surgery. Of during birth. This observation did not yet elicit in-depth in- note, these clinically essential results, durable over a period terpretations regarding the prenatal natural history of
JAMA Pediatrics – American Medical Association
Published: Apr 8, 2021
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