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Local Therapy of Oral Leukoplakia with Vitamin A

Local Therapy of Oral Leukoplakia with Vitamin A Abstract That vitamin A has a marked antikeratinizing effect has been established experimentally in animals and in humans.1 It has also been shown that this effect may be produced by topical application.2,3 In view of reports suggesting a favorable action of vitamin A given by injection in vulvar leukoplakia4 and senile keratoses,5 a clinical trial of this compound in topical form seemed indicated. Ten patients with typical oral leukoplakia of from 3 months' to 10 years' duration, ranging in severity from Grades II to IV of Thoma,6 were treated with oral troches containing 150,000 units of vitamin A each.* The patients were instructed to remove their dentures and allow one troche to dissolve slowly in the mouth twice or three times daily. Treatment periods varied from two to six months. All patients were examined every four to six weeks, and photographs were taken for the record. References 1. Dome Chemicals, Inc., supplied Vi-Dome-"A" buccal tablets, which were used in this study. 2. Flesch, P.: Studies on the Mode of Action of Vitamin A , J. Invest. Dermat. 21:421-434, 1953.Crossref 3. Flesch, P., and Hunt, M.: Local Depilatory Action of Some Unsaturated Compounds , A. M. A. Arch. Dermat. & Syph. 65:261-269, 1952. 4. Sabella, J. D.; Bern, H. A., and Kahn, R. H.: Effects of Locally Applied Vitamin A and Estrogen on Rat Epidermis , Proc. Soc. Exper. Biol. & Med. 76:499-503, 1951. 5. Hyams, M. N., and Bloom, O. H.: Leukoplakia Vulvae: Its Etiology and Results of Treatment with Vitamin A , Am. J. Obst. & Gynec. 53:214-220, 1947. 6. Savitt, L. E., and Obermayer, M. E.: Treatment of Acne Vulgaris and Senile Keratoses with Vitamin A: Results of a Clinical Experiment , J. Invest. Dermat. 14:283-289, 1950. 7. Thoma, K. H.: Oral Surgery , St. Louis, The C. V. Mosby Company, 1948. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Local Therapy of Oral Leukoplakia with Vitamin A

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Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1958.01560110083012
Publisher site
See Article on Publisher Site

Abstract

Abstract That vitamin A has a marked antikeratinizing effect has been established experimentally in animals and in humans.1 It has also been shown that this effect may be produced by topical application.2,3 In view of reports suggesting a favorable action of vitamin A given by injection in vulvar leukoplakia4 and senile keratoses,5 a clinical trial of this compound in topical form seemed indicated. Ten patients with typical oral leukoplakia of from 3 months' to 10 years' duration, ranging in severity from Grades II to IV of Thoma,6 were treated with oral troches containing 150,000 units of vitamin A each.* The patients were instructed to remove their dentures and allow one troche to dissolve slowly in the mouth twice or three times daily. Treatment periods varied from two to six months. All patients were examined every four to six weeks, and photographs were taken for the record. References 1. Dome Chemicals, Inc., supplied Vi-Dome-"A" buccal tablets, which were used in this study. 2. Flesch, P.: Studies on the Mode of Action of Vitamin A , J. Invest. Dermat. 21:421-434, 1953.Crossref 3. Flesch, P., and Hunt, M.: Local Depilatory Action of Some Unsaturated Compounds , A. M. A. Arch. Dermat. & Syph. 65:261-269, 1952. 4. Sabella, J. D.; Bern, H. A., and Kahn, R. H.: Effects of Locally Applied Vitamin A and Estrogen on Rat Epidermis , Proc. Soc. Exper. Biol. & Med. 76:499-503, 1951. 5. Hyams, M. N., and Bloom, O. H.: Leukoplakia Vulvae: Its Etiology and Results of Treatment with Vitamin A , Am. J. Obst. & Gynec. 53:214-220, 1947. 6. Savitt, L. E., and Obermayer, M. E.: Treatment of Acne Vulgaris and Senile Keratoses with Vitamin A: Results of a Clinical Experiment , J. Invest. Dermat. 14:283-289, 1950. 7. Thoma, K. H.: Oral Surgery , St. Louis, The C. V. Mosby Company, 1948.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Nov 1, 1958

References