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LOCAL QUININE THERAPY IN CASES OF INTERSTITIAL KERATITIS AND OLD CORNEAL OPACITIES

LOCAL QUININE THERAPY IN CASES OF INTERSTITIAL KERATITIS AND OLD CORNEAL OPACITIES Abstract In a paper read before the Chicago Ophthalmological Society on Nov. 19, 1934, I1 reported the methods and results of local quinine therapy in trachoma. The rationale of the quinine therapy is that quinine, besides being a bactericide and an astringent, is a protoplasmic poison which penetrates deeply into the tissues when applied locally to mucous membranes. Binz,2 Roth3 and others showed that it destroys leukocytes and lymphocytes in and out of blood vessels, and that its destructive effect on lymphocytes is particularly marked. As Cushny4 stated, quinine acts on the nutrition of almost all forms of protoplasm, causing first an augmentation of its activity, later depression and finally death. Experiments on animals and clinical trials in cases of trachoma showed that 2 per cent and 4 per cent quinine bisulphate ointment and a 10 per cent aqueous solution of quinine bisulphate can be applied locally References 1. Selinger, E.: Studies in Protein Content of Human Aqueous; Influence of Therapeutic Measures; Significance in Papilledema, Papillitis and Other Conditions , Am. J. Ophth. 17:1130 ( (Dec.) ) 1934. 2. Binz, C.: Arch. f. Mikros. Anat. 3:383, 1867Crossref 3. Virchows Arch. f. path. Anat. 46:67, 1869Crossref 4. 51:6, 1870 5. Experimentelle Untersuchungen über das Wesen der Chininwirkung , Berlin, A. Hirschwald, 1868 6. Arch. f. exper. Path. u. Pharmakol. 1:18, 1873Crossref 7. 5:39, 1875 8. 7:275, 1877. 9. Roth: J. Pharmacol. & Exper. Therap. 4:157, 1912. 10. Cushny, A. R.: Text-Book of Pharmacology and Therapeutics , Philadelphia, Lea & Febiger, 1918. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

LOCAL QUININE THERAPY IN CASES OF INTERSTITIAL KERATITIS AND OLD CORNEAL OPACITIES

Archives of Ophthalmology , Volume 13 (5) – May 1, 1935

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Publisher
American Medical Association
Copyright
Copyright © 1935 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1935.00840050107010
Publisher site
See Article on Publisher Site

Abstract

Abstract In a paper read before the Chicago Ophthalmological Society on Nov. 19, 1934, I1 reported the methods and results of local quinine therapy in trachoma. The rationale of the quinine therapy is that quinine, besides being a bactericide and an astringent, is a protoplasmic poison which penetrates deeply into the tissues when applied locally to mucous membranes. Binz,2 Roth3 and others showed that it destroys leukocytes and lymphocytes in and out of blood vessels, and that its destructive effect on lymphocytes is particularly marked. As Cushny4 stated, quinine acts on the nutrition of almost all forms of protoplasm, causing first an augmentation of its activity, later depression and finally death. Experiments on animals and clinical trials in cases of trachoma showed that 2 per cent and 4 per cent quinine bisulphate ointment and a 10 per cent aqueous solution of quinine bisulphate can be applied locally References 1. Selinger, E.: Studies in Protein Content of Human Aqueous; Influence of Therapeutic Measures; Significance in Papilledema, Papillitis and Other Conditions , Am. J. Ophth. 17:1130 ( (Dec.) ) 1934. 2. Binz, C.: Arch. f. Mikros. Anat. 3:383, 1867Crossref 3. Virchows Arch. f. path. Anat. 46:67, 1869Crossref 4. 51:6, 1870 5. Experimentelle Untersuchungen über das Wesen der Chininwirkung , Berlin, A. Hirschwald, 1868 6. Arch. f. exper. Path. u. Pharmakol. 1:18, 1873Crossref 7. 5:39, 1875 8. 7:275, 1877. 9. Roth: J. Pharmacol. & Exper. Therap. 4:157, 1912. 10. Cushny, A. R.: Text-Book of Pharmacology and Therapeutics , Philadelphia, Lea & Febiger, 1918.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: May 1, 1935

References