Abstract The histologic changes induced by the antisyphilitic drugs at the site of injection have attracted comparatively little study, though the clinical incidence of injury is frequent and at times severe.1 In this study I shall attempt to record the pathologic changes induced by the three main types of antisyphilitic drugs-arsenic, mercury and bismuth—in water solutions or in oil suspensions. The experimental work was carried out on rabbits, guinea-pigs and dogs. Arsphenamine was included in this study because of a tendency to revert to its use intramuscularly,2 though the earlier studies of Swift3 and Kolmer4 have called attention to its injurious action on the tissues. EFFECT OF VARIOUS DRUGS ON THE TISSUES Arsphenamine.— The intramuscular administration of arsphenamine is followed by an immediate severe destruction of the tissues at the site of injection (fig. 1). The necrosis of the tissues of the central portion of the area References 1. Barthelemy, R.: Accidents locaux des injections intramusculaires de produits bismuthiques insolubles en suspension huileuse , Ann. d. mal. vén. 20:570 ( (Aug.) ) 1925. 2. Stokes, J. H.: Arsphenamine Subcutaneously and Intramuscularly , Modern Clinical Syphilology , Philadelphia, W. B. Saunders Company, 1926. 3. Richard Sutton: Intramuscular Method , Diseases of the Skin , St. Louis, C. V. Mosby Company, 1926. 4. Swift, H. F.: Absorption of Arsenic Following Intramuscular Injections of Salvarsan and Neosalvarsan , J. Exper. Med. 17:83, 1913.Crossref 5. Kolmer, J. A.: Local Tissue Reactions by Intramuscular Injections, Principles and Practice of Chemotherapy , Philadelphia, W. B. Saunders Company, 1926. 6. Gruhzit, O. M., and Sultzaberger, J. A.: Bismuth Absorption; Distribution and Elimination , Am. J. Syph. 11:103, 1927.
Archives of Dermatology and Syphilology – American Medical Association
Published: Jun 1, 1929
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