Abstract Convalescence after fractures of and operations on bone is prolonged because bone heals more slowly than does soft tissue and because the immobilization required during the process of healing leads to local atrophy of the bone and muscles and to a decrease in the range of motion permitted by the soft tissues of the part. If the union of bone could be hastened and if local atrophy could be prevented considerable economic advantage would result and a proportionately larger number of patients could be treated in orthopedic hospitals each year with the same number of beds. In this article we report a series of clinical experiments in which therapeutic doses of vitamin D and of calcium were administered to normal children receiving an adequate diet in an attempt to hasten union and to prevent local atrophy of bone after stabilizing operations on the feet. We know of no observations on References 1. Watanabe, T.: Experimental Researches on Effect of Avitaminosis on the Healing of Bone Fractures , Virchows Arch. f. path. Anat. 251:281, 1924.Crossref 2. Israel, A., and Frankel, R.: The Influence of Vitaminosis on the Healing of Fractures , Klin. Wchnschr. 5:94, 1926.Crossref 3. Schilowzew, S. P.: The Influence of Avitaminosis , Deutsche Ztschr. f. Chir. 209:320, 1928.Crossref 4. Roegholt, M. M.: The Influence of A, B, C and D Vitamin and the Elements of Calcium and Phosphorus on the Healing of Fractures , Arch. f. klin. Chir. 168:783, 1931. 5. Holasz, G. V., and Marx, Josef: Is Callus Building Influenced Through the Addition of Vitamin C? Arch. f. klin. Chir. 169:121, 1931. 6. Bors, E.: Vigantol and Fracture Healing , Zentralbl. f. Chir. 54:3266, 1927. 7. Collazo, J. A.; Rubina, P., and Varela, B.: The Rôle of Vitamin D in the Regeneration of Bone Tissue and Callus Building in Experimental Fractures , Arch. f. klin. Chir. 158:214, 1930. 8. Moritsch, P., and Krammer, E.: The Influence of a Calcium and Phosphorus Containing Vitamin Preparation (Vito Phos) on Callus Building , Wien. med. Wchnschr. 79:1454, 1929. 9. Pincussen, and Newmann: The Relation of Fracture Healing to Chemical Changes in the Blood and the Influence of Vitamins and Calcium on These Changes , Arch. f. klin. Chir. 165:483, 1931. 10. Hellner, Hans: The Influence of Vigantol on Fracture Callus in Healthy Animals , Deutsche Ztschr. f. Chir. 209:307, 1928.Crossref 11. Vara-Lopez, R.: Experimental Researches on the Influence of Fracture Healing , Deutsche Ztschr. f. Chir. 212:101, 1928.Crossref 12. Swart, H. A.: The Effect of Irradiated Ergosterol on the Healing of Experimentally Produced Fractures in Animals , J. Bone & Joint Surg. 12:360, 1930. 13. Lewis, K. M.: Non-Effect of Irradiated Ergosterol in the Treatment of Fractures , Ann. Surg. 92:415, 1930. 14. Tammann, H.: Retardation of Fracture Healing by Vitasterin , Arch. f. klin. Chir. 165:473, 1930. 15. The cod liver oil contained 20,000 vitamin A and 10,000 vitamin D units to the ounce (29.5 cm.).
Archives of Surgery – American Medical Association
Published: Aug 1, 1934