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LOCAL AMYLOIDOSIS OF THE SKIN

LOCAL AMYLOIDOSIS OF THE SKIN Abstract Amyloidosis of the internal organs has been thoroughly studied by internists and pathologists for many years, but only in recent times has this degenerative change been recognized in the skin. In 1905, Pospelow1 discussed the condition in his textbook. In 1909 Schilder2 examined the skin of fourteen patients who at postmortem examination showed general amyloidosis. In seven of the specimens he was able to demonstrate amyloid, even though the skin was normal clinically. Amyloid is a morphologic, homogeneous, structureless substance, which has peculiar characteristic staining qualities. Methyl violet stains amyloid a metachromatic bright red. Iodine produces a dark brown, and the addition of sulphuric acid changes the brown to a dirty green. The van Gieson method gives a clear yellow. In examining for amyloid one should test with several stains before making a definite diagnosis, because every example of amyloid possesses a different staining intensity, probably owing to References 1. Pospelow, A.: Lehrbuch die Hautkrankheiten , Moscow, 1905. 2. Schilder, Paul: Ueber die amyloide Entartung der Haut , Frankfurt. Ztschr. f. Path. 3:782, 1909. 3. Königstein, H.: Arch. f. Dermat. u. Syph. 148:330. 1925.Crossref 4. Bennhold, H.: Kongress d. deutsch. Gesellsch. f. inn. Med. , 1922, p. 313. 5. Guttmann, C.: Dermat. Ztschr. 28:65, 1923.Crossref 6. Königstein, H.: Wien. klin. Wchnschr. 14:157, 1921. 7. Juliusberg, F.: Zur Kenntnis der Amyloidosis der Haut , Dermat. Ztschr. 29:3, 1923. 8. Freudenthal, F.: Zentralbl. f. Haut und Geschlechtskr. 20:26, 1926 9. 27: 469, 1928 10. 29:100, 608 and 768, 1928. 11. Maschkilleisson and Sirkin: Acta dermat.-venereol. , 1928, no. (10) , p. 1079. 12. Truffi, G.: Gior. ital. di. dermat. e sifil. 70:1, 1929. 13. Jukeliss: Acta dermat.-venereol. , 1929, no. (6) , p. 663. 14. Kreibich, C.: Arch. f. Dermat. u. Syph. 116:385, 1913.Crossref 15. Lindwurm: Ztschr. f. rationelle Med. 14:257, 1862. 16. Kennedy, D.: Arch. f. Dermat. u. Syph. 136:245, 1921.Crossref 17. Hoffmann, E.: Arch. f. Dermat. u. Syph. 146:89, 1924Crossref 18. Deutsch. Dermat. Gesellsch, 1923. 19. This case was presented and discussed by Professor Oppenheim at the Wiener Dermatological Gesellschaft, March, 1930. 20. Maschkilleisson: Acta dermat.-venereol. 11:77, 1930. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1931 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1931.03880230040004
Publisher site
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Abstract

Abstract Amyloidosis of the internal organs has been thoroughly studied by internists and pathologists for many years, but only in recent times has this degenerative change been recognized in the skin. In 1905, Pospelow1 discussed the condition in his textbook. In 1909 Schilder2 examined the skin of fourteen patients who at postmortem examination showed general amyloidosis. In seven of the specimens he was able to demonstrate amyloid, even though the skin was normal clinically. Amyloid is a morphologic, homogeneous, structureless substance, which has peculiar characteristic staining qualities. Methyl violet stains amyloid a metachromatic bright red. Iodine produces a dark brown, and the addition of sulphuric acid changes the brown to a dirty green. The van Gieson method gives a clear yellow. In examining for amyloid one should test with several stains before making a definite diagnosis, because every example of amyloid possesses a different staining intensity, probably owing to References 1. Pospelow, A.: Lehrbuch die Hautkrankheiten , Moscow, 1905. 2. Schilder, Paul: Ueber die amyloide Entartung der Haut , Frankfurt. Ztschr. f. Path. 3:782, 1909. 3. Königstein, H.: Arch. f. Dermat. u. Syph. 148:330. 1925.Crossref 4. Bennhold, H.: Kongress d. deutsch. Gesellsch. f. inn. Med. , 1922, p. 313. 5. Guttmann, C.: Dermat. Ztschr. 28:65, 1923.Crossref 6. Königstein, H.: Wien. klin. Wchnschr. 14:157, 1921. 7. Juliusberg, F.: Zur Kenntnis der Amyloidosis der Haut , Dermat. Ztschr. 29:3, 1923. 8. Freudenthal, F.: Zentralbl. f. Haut und Geschlechtskr. 20:26, 1926 9. 27: 469, 1928 10. 29:100, 608 and 768, 1928. 11. Maschkilleisson and Sirkin: Acta dermat.-venereol. , 1928, no. (10) , p. 1079. 12. Truffi, G.: Gior. ital. di. dermat. e sifil. 70:1, 1929. 13. Jukeliss: Acta dermat.-venereol. , 1929, no. (6) , p. 663. 14. Kreibich, C.: Arch. f. Dermat. u. Syph. 116:385, 1913.Crossref 15. Lindwurm: Ztschr. f. rationelle Med. 14:257, 1862. 16. Kennedy, D.: Arch. f. Dermat. u. Syph. 136:245, 1921.Crossref 17. Hoffmann, E.: Arch. f. Dermat. u. Syph. 146:89, 1924Crossref 18. Deutsch. Dermat. Gesellsch, 1923. 19. This case was presented and discussed by Professor Oppenheim at the Wiener Dermatological Gesellschaft, March, 1930. 20. Maschkilleisson: Acta dermat.-venereol. 11:77, 1930.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: May 1, 1931

References