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LIVER FUNCTION AND OTHER BLOOD CHEMISTRY TESTS IN MULTIPLE SCLEROSIS

LIVER FUNCTION AND OTHER BLOOD CHEMISTRY TESTS IN MULTIPLE SCLEROSIS Abstract DEMYELINATING lesions in the central nervous system have been known to develop in the course of, and particularly in the terminal metabolic derangements of, such disorders as hepatic diseases, uremia, eclampsia, and porphyria. The development of demyelinating lesions of the central nervous system in disorders other than the nervous system has been investigated by various workers with respect to clues for the pathogenesis of the demyelinating lesions of multiple sclerosis. The present study deals with the measurement, quantitative and qualitative, of various substances in the blood and urine often used to discover disordered liver function. Although the tests may be used as a battery to assess liver function, they are also useful in comparing the results with those in normal man and with reports of other investigators studying functions other than those of the liver. None of the patients included in this study had clinical symptoms or signs suggesting liver References 1. Popper, H.: Personal communciation to the authors. 2. Chaney, A. L.: Chaney Modification, Method for Lipid Phosphorus: Personal communication to the authors. 3. References 15 and 16. 4. References 1 and 17. 5. Kunkel H. G.; Ahrens, E. H., Jr., and Eisenmenger, W. J.: Application of Turbidimetric Methods for Estimation of Gamma Globulin and Total Lipid to the Study of Patients with Liver Disease , Gastroenterology 11:499-507, 1948. 6. Youngburg, G. E., and Youngburg, M. V.: Phosphorus Metabolism: I. A System of Blood Phosphorus Analysis , J. Lab. & Clin. Med. 16:158-166, 1930. 7. Gomori, G.: Determination of Phenol in Biological Material , J. Lab. & Clin. Med. 34:275-281, 1949. 8. Bodansky, A.: Phosphatase Studies: II. Determination of Serum Phosphatase; Factors Influencing the Accuracy of the Determination , J. Biol. Chem. 101:93-104, 1933. 9. Fiske, C. H., and Sub-Barow, Y.: Colorimetric Determination of Phosphorus , J. Biol. Chem. 66:375-400, 1925. 10. Schumacher, G. A.: Multiple Sclerosis , J. A. M. A. 143:1059-1065, 1950. 11. Franklin, M.: New Tablet Test for Urinary Bilirubin , J. Lab. & Clin. Med. 34:1145-1150, 1949. 12. Watson, C. J.: Studies of Urobilinogen: Per Diem Excretion of Urobilinogen in the Common Forms of Jaundice and Disease of the Liver , Arch. Int. Med. 59:206-231, 1937. 13. Infectious Diseases, War Department Technical Bulletin : TB MED 206, (Nov. 3) , 1945. 14. Wolfson, W. Q.; Cohn, C.; Calvary, E., and Ichiba, F.: Studies in Serum Proteins: V. Rapid Procedure for the Estimation of Total Protein, True Albumin, Total Globulin, Alpha Globulin, Beta Globulin and Gamma Globulin in 1.0 Ml. of Serum , Am. J. Clin. Path. 18:723-730, 1948. 15. Howe, P. E.: Use of Sodium Sulphate as the Globulin Precipitant in the Determination of Proteins in Blood , J. Biol. Chem. 49:93-107, 1921. 16. de la Huerga, J., and Popper, H.: Estimation of Serum Gamma Globulin Concentration by Turbidimetry , J. Lab. & Clin. Med. 35:459-465, 1950. 17. Winzler, R. J.; Devor, A. W.; Mehl, J. W., and Smyth, I. M.: Studies on the Mucoproteins of Human Plasma: Determination and Isolation , J. Clin. Invest. 27:609-616, 1948. 18. Hanger, F. M.: Serological Differentiation of Obstructive from Hepatogenous Jaundice by Flocculation of Cephalin-Cholesterol Emulsions , J. Clin. Invest. 18:261-269, 1939. 19. de la Huerga, J., and Popper, H.: Standardized Reagent for Thymol Turbidity Test , J. Lab. & Clin. Med. 34:877-880, 1949. 20. Maclagen, N. F.: Thymol Turbidity Test: New Indicator of Liver Dysfunction , Brit. J. Exper. Path. 25:234-241, 1944. 21. Kunkel, H. G.: Estimation of Alterations of Serum Gamma Globulin by a Turbidimetric Technique , Proc. Soc. Exper. Biol. & Med. 66:217-224, 1947. 22. Swank, R. L.: Multiple Sclerosis: Correlation of Its Incidence with Dietary Fat , Am. J. M. Sc. 220:421-430, 1950. 23. Wilmot, V. A., and Swank, R. L.: Influence of Low-Fat Diet on Blood Lipid Levels in Health and in Multiple Sclerosis , Am. J. M. Sc. 223:25-34, 1952. 24. Chiavacci, L. V., and Sperry, W. M.: Concentration of Cholesterol and of Lipid Phosphorus in Blood Serum in Multiple Sclerosis , A. M. A. Arch. Neurol. & Psychiat. 68:37-42, 1952. 25. Fog, T.: On the Pathogenesis of Multiple Sclerosis , Acta psychiat. et neurol. scandinav. (Supp.) 74:22-31, 1951. 26. Jones, H. H.; Jones, H. H., Jr., and Bunch, L. D.: Biochemical Studies in Multiple Sclerosis , Ann. Int. Med. 33:831-840, 1950.Crossref 27. Altmann, O., and Goldhammer, H.: Lipase- und Cholesterinbestimmungen bei der multiplen Sklerose , Wien. klin. Wchnschr. 16:1017-1019, 1937.Crossref 28. Rappaport, F.: Rapid Microchemical Methods for Blood and Cerebrospinal Fluid Examinations , New York, Grune & Stratton, Inc., 1949. 29. Pichler, E., and Reisner, H.: Schwankungen des Cholesterinspiegels bei multipler Sklerose , Wien. klin. Wchnschr. 51:1304-1309, 1938. 30. Frisch, C.: Cholesterinstoffwechsel bei der multiplen Sklerose , Wien. klin. Wchnschr. 50:596-598, 1937. 31. Laignel-Lavastine, M., and Koressios, N. T.: Les troubles du métabolisme des lipoïdes phosphorés dans la sclérose en plaques , Rev. neurol. 64:911-914, 1935. 32. Crandall, L. A., Jr., and Cherry, I. S.: Blood Lipase, Diastase and Esterase in Multiple Sclerosis: Possible Index of Liver Dysfunction , Arch. Neurol. & Psychiat. 27:367-374, 1932. 33. Brickner, R. M.: Esterasic Properties of the Blood in Cases of Multiple Sclerosis: Their Use in Determining Presumptive Activity of the Disease , Arch. Neurol. & Psychiat. 34:466, 1935. 34. Brickner, R. M.; Watters, T.; Wexler, D., and Soltz, S. E.: Changes in Blood Esterase Associated with Changes in Activity in Multiple Sclerosis , Bull. Neurol. Inst. New York 4:656-664, 1936. 35. Richards, C. H., and Wolff, H. G.: Studies in Multiple Sclerosis: Serum Enzymes , Arch. Neurol. & Psychiat. 43:59-69, 1940. 36. Weil, A., and Cleveland, D. A.: Serologic Study of Multiple Sclerosis , Arch. Neurol. & Psychiat. 27:375-388, 1932. 37. Putnam, T. J.: Abnormalities of the Blood Associated with "Encephalomyelitis" and Multiple Sclerosis , Arch. Neurol. & Psychiat. 45:725-726, 1941. 38. Swank, R. L.; Franklin, A. E., and Quastel, J. H.: Paper Chromatography of Blood Plasmas in Multiple Sclerosis , Proc. Soc. Exper. Biol. & Med. 76:183-189, 1951. 39. Bagni, C., and Andreani, G.: Ricerche sulla funzionalità epatica nella sclerosi multipla , Riv. pat. nerv. 71:499-506, 1950. 40. Kabat, E. A.; Freedman, D. A., and Murray, J. P.: Study of the Cerebrospinal Fluid Gamma Globulin in Multiple Sclerosis and in Other Diseases, IV Congrès international de neurologie , Communications 2:39, 1949. 41. Dekaban, A. S.; Brodrick, R. J., and Waugh, T. R.: Hematologic Gastric Acidity and Cerebrospinal Fluid Findings in Multiple Sclerosis , Neurology 2:514-519, 1952. 42. Haug, K.: Leberfunktionsprüfungen bei multipler Sklerose , Monatsschr. Psychiat. u. Neurol. 88:225-247, 1934. 43. Popper, H.; Steigmann, F., and Szanto, P. B.: Quantitative Correlation of Morphologic Liver Changes and Clinical Tests , Am. J. Clin. Path. 19:710-724, 1949. 44. Franklin, M.; Popper, H.; Steigmann, F., Kozoll, D. D.: Relation Between Structural and Functional Alterations of the Liver , J. Lab. & Clin. Med. 33:435-447, 1948. 45. Popper, H.; Steigmann, F.; Meyer, K. A.; Kozoll, D. D., and Franklin, M.: Correlation of Liver Function and Liver Structure: Clinical Applications , Am. J. Med. 6:278-291, 1949. 46. Popper, H.: Discussion: Factors Affecting the Results of Flocculation Tests, in Wolstenholme , G. E. W., Editor: Liver Disease, a Ciba Foundation Symposium , Philadelphia, The Blakiston Company, 1951, pp. 8-10. 47. Lichtman, S. S.: Diseases of the Liver, Gallbladder and Bile Ducts , Ed. 2, Philadelphia, Lea & Febiger, 1949. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

LIVER FUNCTION AND OTHER BLOOD CHEMISTRY TESTS IN MULTIPLE SCLEROSIS

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American Medical Association
Copyright
Copyright © 1954 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1954.02320400001001
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Abstract

Abstract DEMYELINATING lesions in the central nervous system have been known to develop in the course of, and particularly in the terminal metabolic derangements of, such disorders as hepatic diseases, uremia, eclampsia, and porphyria. The development of demyelinating lesions of the central nervous system in disorders other than the nervous system has been investigated by various workers with respect to clues for the pathogenesis of the demyelinating lesions of multiple sclerosis. The present study deals with the measurement, quantitative and qualitative, of various substances in the blood and urine often used to discover disordered liver function. Although the tests may be used as a battery to assess liver function, they are also useful in comparing the results with those in normal man and with reports of other investigators studying functions other than those of the liver. None of the patients included in this study had clinical symptoms or signs suggesting liver References 1. Popper, H.: Personal communciation to the authors. 2. Chaney, A. L.: Chaney Modification, Method for Lipid Phosphorus: Personal communication to the authors. 3. References 15 and 16. 4. References 1 and 17. 5. Kunkel H. G.; Ahrens, E. H., Jr., and Eisenmenger, W. J.: Application of Turbidimetric Methods for Estimation of Gamma Globulin and Total Lipid to the Study of Patients with Liver Disease , Gastroenterology 11:499-507, 1948. 6. Youngburg, G. E., and Youngburg, M. V.: Phosphorus Metabolism: I. A System of Blood Phosphorus Analysis , J. Lab. & Clin. Med. 16:158-166, 1930. 7. Gomori, G.: Determination of Phenol in Biological Material , J. Lab. & Clin. Med. 34:275-281, 1949. 8. Bodansky, A.: Phosphatase Studies: II. Determination of Serum Phosphatase; Factors Influencing the Accuracy of the Determination , J. Biol. Chem. 101:93-104, 1933. 9. Fiske, C. H., and Sub-Barow, Y.: Colorimetric Determination of Phosphorus , J. Biol. Chem. 66:375-400, 1925. 10. Schumacher, G. A.: Multiple Sclerosis , J. A. M. A. 143:1059-1065, 1950. 11. Franklin, M.: New Tablet Test for Urinary Bilirubin , J. Lab. & Clin. Med. 34:1145-1150, 1949. 12. Watson, C. J.: Studies of Urobilinogen: Per Diem Excretion of Urobilinogen in the Common Forms of Jaundice and Disease of the Liver , Arch. Int. Med. 59:206-231, 1937. 13. Infectious Diseases, War Department Technical Bulletin : TB MED 206, (Nov. 3) , 1945. 14. Wolfson, W. Q.; Cohn, C.; Calvary, E., and Ichiba, F.: Studies in Serum Proteins: V. Rapid Procedure for the Estimation of Total Protein, True Albumin, Total Globulin, Alpha Globulin, Beta Globulin and Gamma Globulin in 1.0 Ml. of Serum , Am. J. Clin. Path. 18:723-730, 1948. 15. Howe, P. E.: Use of Sodium Sulphate as the Globulin Precipitant in the Determination of Proteins in Blood , J. Biol. Chem. 49:93-107, 1921. 16. de la Huerga, J., and Popper, H.: Estimation of Serum Gamma Globulin Concentration by Turbidimetry , J. Lab. & Clin. Med. 35:459-465, 1950. 17. Winzler, R. J.; Devor, A. W.; Mehl, J. W., and Smyth, I. M.: Studies on the Mucoproteins of Human Plasma: Determination and Isolation , J. Clin. Invest. 27:609-616, 1948. 18. Hanger, F. M.: Serological Differentiation of Obstructive from Hepatogenous Jaundice by Flocculation of Cephalin-Cholesterol Emulsions , J. Clin. Invest. 18:261-269, 1939. 19. de la Huerga, J., and Popper, H.: Standardized Reagent for Thymol Turbidity Test , J. Lab. & Clin. Med. 34:877-880, 1949. 20. Maclagen, N. F.: Thymol Turbidity Test: New Indicator of Liver Dysfunction , Brit. J. Exper. Path. 25:234-241, 1944. 21. Kunkel, H. G.: Estimation of Alterations of Serum Gamma Globulin by a Turbidimetric Technique , Proc. Soc. Exper. Biol. & Med. 66:217-224, 1947. 22. Swank, R. L.: Multiple Sclerosis: Correlation of Its Incidence with Dietary Fat , Am. J. M. Sc. 220:421-430, 1950. 23. Wilmot, V. A., and Swank, R. L.: Influence of Low-Fat Diet on Blood Lipid Levels in Health and in Multiple Sclerosis , Am. J. M. Sc. 223:25-34, 1952. 24. Chiavacci, L. V., and Sperry, W. M.: Concentration of Cholesterol and of Lipid Phosphorus in Blood Serum in Multiple Sclerosis , A. M. A. Arch. Neurol. & Psychiat. 68:37-42, 1952. 25. Fog, T.: On the Pathogenesis of Multiple Sclerosis , Acta psychiat. et neurol. scandinav. (Supp.) 74:22-31, 1951. 26. Jones, H. H.; Jones, H. H., Jr., and Bunch, L. D.: Biochemical Studies in Multiple Sclerosis , Ann. Int. Med. 33:831-840, 1950.Crossref 27. Altmann, O., and Goldhammer, H.: Lipase- und Cholesterinbestimmungen bei der multiplen Sklerose , Wien. klin. Wchnschr. 16:1017-1019, 1937.Crossref 28. Rappaport, F.: Rapid Microchemical Methods for Blood and Cerebrospinal Fluid Examinations , New York, Grune & Stratton, Inc., 1949. 29. Pichler, E., and Reisner, H.: Schwankungen des Cholesterinspiegels bei multipler Sklerose , Wien. klin. Wchnschr. 51:1304-1309, 1938. 30. Frisch, C.: Cholesterinstoffwechsel bei der multiplen Sklerose , Wien. klin. Wchnschr. 50:596-598, 1937. 31. Laignel-Lavastine, M., and Koressios, N. T.: Les troubles du métabolisme des lipoïdes phosphorés dans la sclérose en plaques , Rev. neurol. 64:911-914, 1935. 32. Crandall, L. A., Jr., and Cherry, I. S.: Blood Lipase, Diastase and Esterase in Multiple Sclerosis: Possible Index of Liver Dysfunction , Arch. Neurol. & Psychiat. 27:367-374, 1932. 33. Brickner, R. M.: Esterasic Properties of the Blood in Cases of Multiple Sclerosis: Their Use in Determining Presumptive Activity of the Disease , Arch. Neurol. & Psychiat. 34:466, 1935. 34. Brickner, R. M.; Watters, T.; Wexler, D., and Soltz, S. E.: Changes in Blood Esterase Associated with Changes in Activity in Multiple Sclerosis , Bull. Neurol. Inst. New York 4:656-664, 1936. 35. Richards, C. H., and Wolff, H. G.: Studies in Multiple Sclerosis: Serum Enzymes , Arch. Neurol. & Psychiat. 43:59-69, 1940. 36. Weil, A., and Cleveland, D. A.: Serologic Study of Multiple Sclerosis , Arch. Neurol. & Psychiat. 27:375-388, 1932. 37. Putnam, T. J.: Abnormalities of the Blood Associated with "Encephalomyelitis" and Multiple Sclerosis , Arch. Neurol. & Psychiat. 45:725-726, 1941. 38. Swank, R. L.; Franklin, A. E., and Quastel, J. H.: Paper Chromatography of Blood Plasmas in Multiple Sclerosis , Proc. Soc. Exper. Biol. & Med. 76:183-189, 1951. 39. Bagni, C., and Andreani, G.: Ricerche sulla funzionalità epatica nella sclerosi multipla , Riv. pat. nerv. 71:499-506, 1950. 40. Kabat, E. A.; Freedman, D. A., and Murray, J. P.: Study of the Cerebrospinal Fluid Gamma Globulin in Multiple Sclerosis and in Other Diseases, IV Congrès international de neurologie , Communications 2:39, 1949. 41. Dekaban, A. S.; Brodrick, R. J., and Waugh, T. R.: Hematologic Gastric Acidity and Cerebrospinal Fluid Findings in Multiple Sclerosis , Neurology 2:514-519, 1952. 42. Haug, K.: Leberfunktionsprüfungen bei multipler Sklerose , Monatsschr. Psychiat. u. Neurol. 88:225-247, 1934. 43. Popper, H.; Steigmann, F., and Szanto, P. B.: Quantitative Correlation of Morphologic Liver Changes and Clinical Tests , Am. J. Clin. Path. 19:710-724, 1949. 44. Franklin, M.; Popper, H.; Steigmann, F., Kozoll, D. D.: Relation Between Structural and Functional Alterations of the Liver , J. Lab. & Clin. Med. 33:435-447, 1948. 45. Popper, H.; Steigmann, F.; Meyer, K. A.; Kozoll, D. D., and Franklin, M.: Correlation of Liver Function and Liver Structure: Clinical Applications , Am. J. Med. 6:278-291, 1949. 46. Popper, H.: Discussion: Factors Affecting the Results of Flocculation Tests, in Wolstenholme , G. E. W., Editor: Liver Disease, a Ciba Foundation Symposium , Philadelphia, The Blakiston Company, 1951, pp. 8-10. 47. Lichtman, S. S.: Diseases of the Liver, Gallbladder and Bile Ducts , Ed. 2, Philadelphia, Lea & Febiger, 1949.

Journal

A.M.A. Archives of Neurology & PsychiatryAmerican Medical Association

Published: Apr 1, 1954

References