Access the full text.
Sign up today, get DeepDyve free for 14 days.
Abstract DEMYELINATING lesions in the central nervous system have been known to develop in the course of, and particularly in the terminal metabolic derangements of, such disorders as hepatic diseases, uremia, eclampsia, and porphyria. The development of demyelinating lesions of the central nervous system in disorders other than the nervous system has been investigated by various workers with respect to clues for the pathogenesis of the demyelinating lesions of multiple sclerosis. The present study deals with the measurement, quantitative and qualitative, of various substances in the blood and urine often used to discover disordered liver function. Although the tests may be used as a battery to assess liver function, they are also useful in comparing the results with those in normal man and with reports of other investigators studying functions other than those of the liver. None of the patients included in this study had clinical symptoms or signs suggesting liver References 1. Popper, H.: Personal communciation to the authors. 2. Chaney, A. L.: Chaney Modification, Method for Lipid Phosphorus: Personal communication to the authors. 3. References 15 and 16. 4. References 1 and 17. 5. Kunkel H. G.; Ahrens, E. H., Jr., and Eisenmenger, W. J.: Application of Turbidimetric Methods for Estimation of Gamma Globulin and Total Lipid to the Study of Patients with Liver Disease , Gastroenterology 11:499-507, 1948. 6. Youngburg, G. E., and Youngburg, M. V.: Phosphorus Metabolism: I. A System of Blood Phosphorus Analysis , J. Lab. & Clin. Med. 16:158-166, 1930. 7. Gomori, G.: Determination of Phenol in Biological Material , J. Lab. & Clin. Med. 34:275-281, 1949. 8. Bodansky, A.: Phosphatase Studies: II. Determination of Serum Phosphatase; Factors Influencing the Accuracy of the Determination , J. Biol. Chem. 101:93-104, 1933. 9. Fiske, C. H., and Sub-Barow, Y.: Colorimetric Determination of Phosphorus , J. Biol. Chem. 66:375-400, 1925. 10. Schumacher, G. A.: Multiple Sclerosis , J. A. M. A. 143:1059-1065, 1950. 11. Franklin, M.: New Tablet Test for Urinary Bilirubin , J. Lab. & Clin. Med. 34:1145-1150, 1949. 12. Watson, C. J.: Studies of Urobilinogen: Per Diem Excretion of Urobilinogen in the Common Forms of Jaundice and Disease of the Liver , Arch. Int. Med. 59:206-231, 1937. 13. Infectious Diseases, War Department Technical Bulletin : TB MED 206, (Nov. 3) , 1945. 14. Wolfson, W. Q.; Cohn, C.; Calvary, E., and Ichiba, F.: Studies in Serum Proteins: V. Rapid Procedure for the Estimation of Total Protein, True Albumin, Total Globulin, Alpha Globulin, Beta Globulin and Gamma Globulin in 1.0 Ml. of Serum , Am. J. Clin. Path. 18:723-730, 1948. 15. Howe, P. E.: Use of Sodium Sulphate as the Globulin Precipitant in the Determination of Proteins in Blood , J. Biol. Chem. 49:93-107, 1921. 16. de la Huerga, J., and Popper, H.: Estimation of Serum Gamma Globulin Concentration by Turbidimetry , J. Lab. & Clin. Med. 35:459-465, 1950. 17. Winzler, R. J.; Devor, A. W.; Mehl, J. W., and Smyth, I. M.: Studies on the Mucoproteins of Human Plasma: Determination and Isolation , J. Clin. Invest. 27:609-616, 1948. 18. Hanger, F. M.: Serological Differentiation of Obstructive from Hepatogenous Jaundice by Flocculation of Cephalin-Cholesterol Emulsions , J. Clin. Invest. 18:261-269, 1939. 19. de la Huerga, J., and Popper, H.: Standardized Reagent for Thymol Turbidity Test , J. Lab. & Clin. Med. 34:877-880, 1949. 20. Maclagen, N. F.: Thymol Turbidity Test: New Indicator of Liver Dysfunction , Brit. J. Exper. Path. 25:234-241, 1944. 21. Kunkel, H. G.: Estimation of Alterations of Serum Gamma Globulin by a Turbidimetric Technique , Proc. Soc. Exper. Biol. & Med. 66:217-224, 1947. 22. Swank, R. L.: Multiple Sclerosis: Correlation of Its Incidence with Dietary Fat , Am. J. M. Sc. 220:421-430, 1950. 23. Wilmot, V. A., and Swank, R. L.: Influence of Low-Fat Diet on Blood Lipid Levels in Health and in Multiple Sclerosis , Am. J. M. Sc. 223:25-34, 1952. 24. Chiavacci, L. V., and Sperry, W. M.: Concentration of Cholesterol and of Lipid Phosphorus in Blood Serum in Multiple Sclerosis , A. M. A. Arch. Neurol. & Psychiat. 68:37-42, 1952. 25. Fog, T.: On the Pathogenesis of Multiple Sclerosis , Acta psychiat. et neurol. scandinav. (Supp.) 74:22-31, 1951. 26. Jones, H. H.; Jones, H. H., Jr., and Bunch, L. D.: Biochemical Studies in Multiple Sclerosis , Ann. Int. Med. 33:831-840, 1950.Crossref 27. Altmann, O., and Goldhammer, H.: Lipase- und Cholesterinbestimmungen bei der multiplen Sklerose , Wien. klin. Wchnschr. 16:1017-1019, 1937.Crossref 28. Rappaport, F.: Rapid Microchemical Methods for Blood and Cerebrospinal Fluid Examinations , New York, Grune & Stratton, Inc., 1949. 29. Pichler, E., and Reisner, H.: Schwankungen des Cholesterinspiegels bei multipler Sklerose , Wien. klin. Wchnschr. 51:1304-1309, 1938. 30. Frisch, C.: Cholesterinstoffwechsel bei der multiplen Sklerose , Wien. klin. Wchnschr. 50:596-598, 1937. 31. Laignel-Lavastine, M., and Koressios, N. T.: Les troubles du métabolisme des lipoïdes phosphorés dans la sclérose en plaques , Rev. neurol. 64:911-914, 1935. 32. Crandall, L. A., Jr., and Cherry, I. S.: Blood Lipase, Diastase and Esterase in Multiple Sclerosis: Possible Index of Liver Dysfunction , Arch. Neurol. & Psychiat. 27:367-374, 1932. 33. Brickner, R. M.: Esterasic Properties of the Blood in Cases of Multiple Sclerosis: Their Use in Determining Presumptive Activity of the Disease , Arch. Neurol. & Psychiat. 34:466, 1935. 34. Brickner, R. M.; Watters, T.; Wexler, D., and Soltz, S. E.: Changes in Blood Esterase Associated with Changes in Activity in Multiple Sclerosis , Bull. Neurol. Inst. New York 4:656-664, 1936. 35. Richards, C. H., and Wolff, H. G.: Studies in Multiple Sclerosis: Serum Enzymes , Arch. Neurol. & Psychiat. 43:59-69, 1940. 36. Weil, A., and Cleveland, D. A.: Serologic Study of Multiple Sclerosis , Arch. Neurol. & Psychiat. 27:375-388, 1932. 37. Putnam, T. J.: Abnormalities of the Blood Associated with "Encephalomyelitis" and Multiple Sclerosis , Arch. Neurol. & Psychiat. 45:725-726, 1941. 38. Swank, R. L.; Franklin, A. E., and Quastel, J. H.: Paper Chromatography of Blood Plasmas in Multiple Sclerosis , Proc. Soc. Exper. Biol. & Med. 76:183-189, 1951. 39. Bagni, C., and Andreani, G.: Ricerche sulla funzionalità epatica nella sclerosi multipla , Riv. pat. nerv. 71:499-506, 1950. 40. Kabat, E. A.; Freedman, D. A., and Murray, J. P.: Study of the Cerebrospinal Fluid Gamma Globulin in Multiple Sclerosis and in Other Diseases, IV Congrès international de neurologie , Communications 2:39, 1949. 41. Dekaban, A. S.; Brodrick, R. J., and Waugh, T. R.: Hematologic Gastric Acidity and Cerebrospinal Fluid Findings in Multiple Sclerosis , Neurology 2:514-519, 1952. 42. Haug, K.: Leberfunktionsprüfungen bei multipler Sklerose , Monatsschr. Psychiat. u. Neurol. 88:225-247, 1934. 43. Popper, H.; Steigmann, F., and Szanto, P. B.: Quantitative Correlation of Morphologic Liver Changes and Clinical Tests , Am. J. Clin. Path. 19:710-724, 1949. 44. Franklin, M.; Popper, H.; Steigmann, F., Kozoll, D. D.: Relation Between Structural and Functional Alterations of the Liver , J. Lab. & Clin. Med. 33:435-447, 1948. 45. Popper, H.; Steigmann, F.; Meyer, K. A.; Kozoll, D. D., and Franklin, M.: Correlation of Liver Function and Liver Structure: Clinical Applications , Am. J. Med. 6:278-291, 1949. 46. Popper, H.: Discussion: Factors Affecting the Results of Flocculation Tests, in Wolstenholme , G. E. W., Editor: Liver Disease, a Ciba Foundation Symposium , Philadelphia, The Blakiston Company, 1951, pp. 8-10. 47. Lichtman, S. S.: Diseases of the Liver, Gallbladder and Bile Ducts , Ed. 2, Philadelphia, Lea & Febiger, 1949.
A.M.A. Archives of Neurology & Psychiatry – American Medical Association
Published: Apr 1, 1954
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.