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Liver Damage in Acute Self-induced Hypermanganemia

Liver Damage in Acute Self-induced Hypermanganemia Abstract • A case of self-induced hypermanganemia is described. In addition to the local corrosive effects of potassium permanganate at the site of injection, hypermanganemia was accompanied by liver damage similar to that seen in experimental animals. (Arch Intern Med 1982;142:405-406) References 1. Hine CH, Pasi A: Manganese intoxication. West J Med 1975;123:101-107. 2. Mena I, Court J, Fuenzalida S, et al: Modification of chronic manganese poisoning. N Engl J Med 1970;282:5-10.Crossref 3. Witzleben CL, Pitlick P, Bergmeyer J, et al: Acute manganese overload: A new experimental model of intrahepatic cholestasis. Toxicol Appl Pharmacol 1968;53:409-422. 4. Wasserman D, Wasserman M: The ultrastructure of the liver cell in subacute manganese administration. Environ Res 1977;14:379-390.Crossref 5. Hancock JA Jr: Methodology for Analytical Toxicology , Sunshine I (ed). Boca Raton, Fla, CRC Press, 1975, pp 217-218. 6. Wade A (ed): Martindale: The Extra Pharmacopoeia , ed 27. London, Pharmaceutical Press, 1977, p 1202. 7. Allain P, Aauras Y: Les taux de manganese dans le sang. Nouv Presse Med 1978;7:2395 8. Cotzias GC: Manganese in health and disease. Physiol Rev 1958;38:503-532. 9. Singh J, Husain R, Tandon SK, et al: Biochemical and histopathological alterations in early manganese toxicity in rats. Environ Physiol Biochem 1974;4:16-23. 10. Baxter DJ, Smith WO, Klein GC: Some effects of acute manganese excess in rats. Proc Soc Exp Biol Med 1965;119:966-970. 11. Alstatt LB, Pollacil S, Feldman MH, et al: Liver manganese in hemochromatosis. Proc Soc Exp Biol Med 1967;124:353-355. 12. De Lamirande E, Plaa GL: Dose and time relationships in manganese-bilirubin cholestasis. Toxicol Appl Pharmacol 1979;49:257-263.Crossref 13. De Lamirande E, Plaa GL: Role of manganese, bilirubin and sulfobromophthalein in manganese bilirubin cholestasis in rats. Proc Soc Exp Biol Med 1978;158:283-287. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Liver Damage in Acute Self-induced Hypermanganemia

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1982.00340150205041
Publisher site
See Article on Publisher Site

Abstract

Abstract • A case of self-induced hypermanganemia is described. In addition to the local corrosive effects of potassium permanganate at the site of injection, hypermanganemia was accompanied by liver damage similar to that seen in experimental animals. (Arch Intern Med 1982;142:405-406) References 1. Hine CH, Pasi A: Manganese intoxication. West J Med 1975;123:101-107. 2. Mena I, Court J, Fuenzalida S, et al: Modification of chronic manganese poisoning. N Engl J Med 1970;282:5-10.Crossref 3. Witzleben CL, Pitlick P, Bergmeyer J, et al: Acute manganese overload: A new experimental model of intrahepatic cholestasis. Toxicol Appl Pharmacol 1968;53:409-422. 4. Wasserman D, Wasserman M: The ultrastructure of the liver cell in subacute manganese administration. Environ Res 1977;14:379-390.Crossref 5. Hancock JA Jr: Methodology for Analytical Toxicology , Sunshine I (ed). Boca Raton, Fla, CRC Press, 1975, pp 217-218. 6. Wade A (ed): Martindale: The Extra Pharmacopoeia , ed 27. London, Pharmaceutical Press, 1977, p 1202. 7. Allain P, Aauras Y: Les taux de manganese dans le sang. Nouv Presse Med 1978;7:2395 8. Cotzias GC: Manganese in health and disease. Physiol Rev 1958;38:503-532. 9. Singh J, Husain R, Tandon SK, et al: Biochemical and histopathological alterations in early manganese toxicity in rats. Environ Physiol Biochem 1974;4:16-23. 10. Baxter DJ, Smith WO, Klein GC: Some effects of acute manganese excess in rats. Proc Soc Exp Biol Med 1965;119:966-970. 11. Alstatt LB, Pollacil S, Feldman MH, et al: Liver manganese in hemochromatosis. Proc Soc Exp Biol Med 1967;124:353-355. 12. De Lamirande E, Plaa GL: Dose and time relationships in manganese-bilirubin cholestasis. Toxicol Appl Pharmacol 1979;49:257-263.Crossref 13. De Lamirande E, Plaa GL: Role of manganese, bilirubin and sulfobromophthalein in manganese bilirubin cholestasis in rats. Proc Soc Exp Biol Med 1978;158:283-287.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Feb 1, 1982

References