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Live Rubella Virus Vaccin n Tuberculous Children

Live Rubella Virus Vaccin n Tuberculous Children Abstract RUBEOLA is known to cause depression of tuberculin skin reactivity and to exert a deleterious effect on the clinical course of untreated, childhood tuberculosis.1,2 The live, attenuated measles virus vaccine has also been shown to depress skin reactivity and possibly to affect adversely the clinical status of the unrecognized tuberculous child.1,3,4 Since rubella and rubeola are both exanthematous, viral diseases, it is understandable that the live, attenuated rubella virus vaccine might be suspected of effects similar to those related to the measles vaccine. It is desirable, therefore, that the safety of the rubella product be established for the tuberculous individual before its widespread distribution for clinical use. The present report describes our experience with 18 hospitalized children under treatment for tuberculosis who were inoculated with the Cendehill strain of attenuated rubella virus. Materials and Methods Study Outline.—The study group was composed of 24 tuberculous children ranging in References 1. Starr, S., and Berkovich, S.: Effects of Measles, Gamma-Globulin-Modified Measles and Vaccine Measles on the Tuberculin Test , New Eng J Med 270:386-391, 1964.Crossref 2. Kendig, E., and Hudgens, R.: The Effect of Rubeola on Tuberculosis Under Antimicrobial Therapy , Pediatrics 24:616-618, 1959. 3. Enders, J.F., and Katz, S.L.: Present Status of Live Rubeola Vaccines in the United States, First International Conference on Vaccines Against Viral and Rickettsial Infections, Pan American Health Organization, Scientific Publication No. 147, May, 1967. 4. Bonforte, R.J., et al: Tuberculosis Meningitis Due to Primary Drug-Resistant Mycobacterium tuberculosis hominis , Pediatrics 42:969-975, 1968. 5. Berkovich, S., and Pangan, J.: Recoveries of Virus From Premature Infants During Outbreaks of Respiratory Disease: The Relation of Echo Virus Type 22 to Disease of the Upper and Lower Respiratory Tract in the Premature Infant , Bull NY Acad Med 44:377-387, 1968. 6. Melnick, J.L.; Wenner, H.A.; and Rosen, L.: The Enteroviruses , Diagnostic Procedures for Virus and Rickettsial Diseases , ed 3, New York: American Public Health Assoc, 1964. 7. Cooper, L.Z., et al: Experience With a Modified Rubella Hemagglutination Inhibition Antibody Test , JAMA 207:89-93, 1969.Crossref 8. Peetermans, J., and Huygelen, C.: Attenuation of Rubella Virus by Serial Passage in Primary Rabbit Kidney Cells: I. Growth Characteristics in Vitro and Production of Experimental Vaccines at Different Passage Levels , Arch Ges Virusforsch 21: 133-142, 1967.Crossref 9. DuPan, R.M., et al: Clinical Trials With a Live Attenuated Rubella Virus Vaccine , Amer J Dis Child 115:658-662 ( (June) ) 1968.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Live Rubella Virus Vaccin n Tuberculous Children

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Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1969.02100040254018
Publisher site
See Article on Publisher Site

Abstract

Abstract RUBEOLA is known to cause depression of tuberculin skin reactivity and to exert a deleterious effect on the clinical course of untreated, childhood tuberculosis.1,2 The live, attenuated measles virus vaccine has also been shown to depress skin reactivity and possibly to affect adversely the clinical status of the unrecognized tuberculous child.1,3,4 Since rubella and rubeola are both exanthematous, viral diseases, it is understandable that the live, attenuated rubella virus vaccine might be suspected of effects similar to those related to the measles vaccine. It is desirable, therefore, that the safety of the rubella product be established for the tuberculous individual before its widespread distribution for clinical use. The present report describes our experience with 18 hospitalized children under treatment for tuberculosis who were inoculated with the Cendehill strain of attenuated rubella virus. Materials and Methods Study Outline.—The study group was composed of 24 tuberculous children ranging in References 1. Starr, S., and Berkovich, S.: Effects of Measles, Gamma-Globulin-Modified Measles and Vaccine Measles on the Tuberculin Test , New Eng J Med 270:386-391, 1964.Crossref 2. Kendig, E., and Hudgens, R.: The Effect of Rubeola on Tuberculosis Under Antimicrobial Therapy , Pediatrics 24:616-618, 1959. 3. Enders, J.F., and Katz, S.L.: Present Status of Live Rubeola Vaccines in the United States, First International Conference on Vaccines Against Viral and Rickettsial Infections, Pan American Health Organization, Scientific Publication No. 147, May, 1967. 4. Bonforte, R.J., et al: Tuberculosis Meningitis Due to Primary Drug-Resistant Mycobacterium tuberculosis hominis , Pediatrics 42:969-975, 1968. 5. Berkovich, S., and Pangan, J.: Recoveries of Virus From Premature Infants During Outbreaks of Respiratory Disease: The Relation of Echo Virus Type 22 to Disease of the Upper and Lower Respiratory Tract in the Premature Infant , Bull NY Acad Med 44:377-387, 1968. 6. Melnick, J.L.; Wenner, H.A.; and Rosen, L.: The Enteroviruses , Diagnostic Procedures for Virus and Rickettsial Diseases , ed 3, New York: American Public Health Assoc, 1964. 7. Cooper, L.Z., et al: Experience With a Modified Rubella Hemagglutination Inhibition Antibody Test , JAMA 207:89-93, 1969.Crossref 8. Peetermans, J., and Huygelen, C.: Attenuation of Rubella Virus by Serial Passage in Primary Rabbit Kidney Cells: I. Growth Characteristics in Vitro and Production of Experimental Vaccines at Different Passage Levels , Arch Ges Virusforsch 21: 133-142, 1967.Crossref 9. DuPan, R.M., et al: Clinical Trials With a Live Attenuated Rubella Virus Vaccine , Amer J Dis Child 115:658-662 ( (June) ) 1968.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Aug 1, 1969

References