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Lipopolysaccharide Tolerance Inhibits Eye Inflammation: II. Preliminary Studies on the Mechanism

Lipopolysaccharide Tolerance Inhibits Eye Inflammation: II. Preliminary Studies on the Mechanism Abstract • The effect of endotoxin tolerance on ocular inflammation was studied in rabbits. Compared with a control group, a passive Arthus reaction in tolerant rabbits was characterized by a sharp decline in the expected increase in vascular permeability and slightly reduced leukocyte extravasation. Aqueous humor withdrawal (paracentesis) and intravitreal injection of prostaglandin E2 were also examined in lipopolysaccharide (LPS)-tolerant rabbits; in both circumstances, ocular protein exudation was decreased. These studies suggest that the prostaglandin system is particularly affected in the ocular responses of LPS-tolerant rabbits, and raise the possibility that other phenomena described in LPS tolerance may have a similar basis. References 1. Greisman SE, Hornick RB: Mechanisms of endotoxin tolerance with special reference to man . J Infect Dis 1973;128( (suppl) ):257-268.Crossref 2. Milner KC: Patterns of tolerance to endotoxin . J Infect Dis 1973;128( (suppl) ):227-237.Crossref 3. Ayo C: Toxic ocular reaction: New property of Shwartzman toxins . J Immunol 1943;46:113-125. 4. Cousins SW, Rosenbaum JT, Guss RB, et al: Ocular albumin fluorophotometric quantitation of endotoxin induced vascular permeability . Infect Immun 1982;36:730-736. 5. Levene RZ, Breinen GM: Ocular effects of endotoxin . Arch Ophthalmol 1957;61:568-577.Crossref 6. Howes EL Jr, Goldyne ME, Perez HD, et al: Lipopolysaccharide tolerance inhibits ocular inflammation: I. Reduced immune complex or lipopolysaccharide effects . Arch Ophthalmol 1985;103:257-260.Crossref 7. Bhattacherjee P, Phylactos A: Increased prostaglandin synthetase activity in inflamed tissues of the rabbit eye . Eur J Pharmacol 1977; 44:75-80.Crossref 8. Bhattacherjee P, Hammond B, Salmon JA, et al: Chemotactic response to some arachidonic acid lipoxygenase products in the rabbit eye . Eur J Pharmacol 1981;73:21-28.Crossref 9. Al-Ghadyan A, Mead A, Sears M: Increased pressure after paracentesis of the rabbit eye is completely accounted for by prostaglandin synthesis and release plus pupillary blockade . Invest Ophthalmol 1979;18:361-365. 10. Neufeld AH, Jampol LM, Sears ML: Aspirin prevents the disruption of the blood aqueous barrier in the rabbit eye . Nature 1972;238:158-159.Crossref 11. Neufeld AH, Sears ML: The site of action of prostaglandin E2 on the disruption of blood-aqueous barrier in the rabbit eye . Exp Eye Res 1973;17:445-448.Crossref 12. Howes EL Jr, McKay DG: Comparison of the ocular effects of circulating endotoxin and immune complexes: Role of vasoactive amines . J Immunol 1975;114:734-737. 13. Howes EL Jr, Char DH, Christensen M: Aqueous immune complexes in immunogenic uveitis . Invest Ophthalmol 1972;23:715-718. 14. Jensen PR, Aronson SB, Pollycove M, et al: Mechanisms of host response in the eye: III. Interocular protein transfer . Arch Ophthalmol 1967;77:814-817.Crossref 15. Crawford JP, Movat HZ, Ranadine NS, et al: Pathways to inflammation induced by immune complexes: Development of the Arthus reaction . Fed Proc 1982;41:2583-2587. 16. Eakins KE, Whitelocke RAF, Perkins ES, et al: Release of prostaglandins in ocular inflammation in rabbits . Nature New Biol 1972;239:248-249.Crossref 17. Wedmore C, Williams TJ: Control of vascular permeability by polymorphonuclear leukocytes in inflammation . Nature 1981;289:646-650.Crossref 18. Kopaniak MM, Movat HZ: Kinetics of acute inflammation induced by Escherichia coli in rabbits: II. The effect of hyperimmunization, complement depletion, and depletion of leukocytes . Am J Pathol 1983;110:13-29. 19. Williams RN, Paterson CA: PMN accumulation in aqueous humor and iris-ciliary body during intraocular inflammation . Invest Ophthalmol Vis Sci 1984;25:105-108. 20. Rosenbaum JT, Howes EL Jr, Goldstein IM: Endotoxin tolerance diminishes some antiinflammatory effects of endotoxin , abstracted. Fed Proc 1982;41:558. 21. Wong KL, Howes EL Jr: Intraocular injection of prostaglandins: Modification of response to circulating bacterial endotoxin . Arch Ophthalmol 1983;101:275-279.Crossref 22. Bito LZ: The effects of experimental uveitis on anterior uveal prostaglandin transport and aqueous humor composition . Invest Ophthalmol Vis Sci 1974;13:959-966. 23. Howes EL Jr, Rosenbaum JT, Cruse VK: Ocular inflammation induced by intravitreal endotoxin (LPS) is enhanced in LPS tolerant rabbits , abstracted. Invest Ophthalmol Vis Sci 1984;25( (suppl) ):29. 24. Howes EL Jr, Wong KL, Hartiala KT, et al: Complement and polymorphonuclear leukocytes do not determine the vascular permeability induced by intraocular LPS. Am J Pathol, in press. 25. Skarnes RC, Braan SK, Hull SS, et al: Role of prostaglandin E in the biphasic fever response to endotoxin . J Exp Med 1981;154:112-122.Crossref 26. Sraer JD, Moulonguet-Doleris L, Delarue F, et al: Prostaglandin synthesis by glomeruli isolated from rats with glycerol-induced acute renal failure . Circ Res 1981;49:775-783.Crossref 27. Andrews C, Nolan JP, Venuto RC: Effects of endotoxin tolerance on the hemodynamic changes associated with glycerol administration . Nephron 1981;28:141-144.Crossref 28. Wahl LM, Rosenstreich DL, Glove LM, et al: Defective prostaglandin synthesis by C3H/HeJ macrophage stimulated with endotoxin preparations . Infect Immun 1979;23:8-13. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Lipopolysaccharide Tolerance Inhibits Eye Inflammation: II. Preliminary Studies on the Mechanism

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Publisher
American Medical Association
Copyright
Copyright © 1985 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1985.01050020113032
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Abstract

Abstract • The effect of endotoxin tolerance on ocular inflammation was studied in rabbits. Compared with a control group, a passive Arthus reaction in tolerant rabbits was characterized by a sharp decline in the expected increase in vascular permeability and slightly reduced leukocyte extravasation. Aqueous humor withdrawal (paracentesis) and intravitreal injection of prostaglandin E2 were also examined in lipopolysaccharide (LPS)-tolerant rabbits; in both circumstances, ocular protein exudation was decreased. These studies suggest that the prostaglandin system is particularly affected in the ocular responses of LPS-tolerant rabbits, and raise the possibility that other phenomena described in LPS tolerance may have a similar basis. References 1. Greisman SE, Hornick RB: Mechanisms of endotoxin tolerance with special reference to man . J Infect Dis 1973;128( (suppl) ):257-268.Crossref 2. Milner KC: Patterns of tolerance to endotoxin . J Infect Dis 1973;128( (suppl) ):227-237.Crossref 3. Ayo C: Toxic ocular reaction: New property of Shwartzman toxins . J Immunol 1943;46:113-125. 4. Cousins SW, Rosenbaum JT, Guss RB, et al: Ocular albumin fluorophotometric quantitation of endotoxin induced vascular permeability . Infect Immun 1982;36:730-736. 5. Levene RZ, Breinen GM: Ocular effects of endotoxin . Arch Ophthalmol 1957;61:568-577.Crossref 6. Howes EL Jr, Goldyne ME, Perez HD, et al: Lipopolysaccharide tolerance inhibits ocular inflammation: I. Reduced immune complex or lipopolysaccharide effects . Arch Ophthalmol 1985;103:257-260.Crossref 7. Bhattacherjee P, Phylactos A: Increased prostaglandin synthetase activity in inflamed tissues of the rabbit eye . Eur J Pharmacol 1977; 44:75-80.Crossref 8. Bhattacherjee P, Hammond B, Salmon JA, et al: Chemotactic response to some arachidonic acid lipoxygenase products in the rabbit eye . Eur J Pharmacol 1981;73:21-28.Crossref 9. Al-Ghadyan A, Mead A, Sears M: Increased pressure after paracentesis of the rabbit eye is completely accounted for by prostaglandin synthesis and release plus pupillary blockade . Invest Ophthalmol 1979;18:361-365. 10. Neufeld AH, Jampol LM, Sears ML: Aspirin prevents the disruption of the blood aqueous barrier in the rabbit eye . Nature 1972;238:158-159.Crossref 11. Neufeld AH, Sears ML: The site of action of prostaglandin E2 on the disruption of blood-aqueous barrier in the rabbit eye . Exp Eye Res 1973;17:445-448.Crossref 12. Howes EL Jr, McKay DG: Comparison of the ocular effects of circulating endotoxin and immune complexes: Role of vasoactive amines . J Immunol 1975;114:734-737. 13. Howes EL Jr, Char DH, Christensen M: Aqueous immune complexes in immunogenic uveitis . Invest Ophthalmol 1972;23:715-718. 14. Jensen PR, Aronson SB, Pollycove M, et al: Mechanisms of host response in the eye: III. Interocular protein transfer . Arch Ophthalmol 1967;77:814-817.Crossref 15. Crawford JP, Movat HZ, Ranadine NS, et al: Pathways to inflammation induced by immune complexes: Development of the Arthus reaction . Fed Proc 1982;41:2583-2587. 16. Eakins KE, Whitelocke RAF, Perkins ES, et al: Release of prostaglandins in ocular inflammation in rabbits . Nature New Biol 1972;239:248-249.Crossref 17. Wedmore C, Williams TJ: Control of vascular permeability by polymorphonuclear leukocytes in inflammation . Nature 1981;289:646-650.Crossref 18. Kopaniak MM, Movat HZ: Kinetics of acute inflammation induced by Escherichia coli in rabbits: II. The effect of hyperimmunization, complement depletion, and depletion of leukocytes . Am J Pathol 1983;110:13-29. 19. Williams RN, Paterson CA: PMN accumulation in aqueous humor and iris-ciliary body during intraocular inflammation . Invest Ophthalmol Vis Sci 1984;25:105-108. 20. Rosenbaum JT, Howes EL Jr, Goldstein IM: Endotoxin tolerance diminishes some antiinflammatory effects of endotoxin , abstracted. Fed Proc 1982;41:558. 21. Wong KL, Howes EL Jr: Intraocular injection of prostaglandins: Modification of response to circulating bacterial endotoxin . Arch Ophthalmol 1983;101:275-279.Crossref 22. Bito LZ: The effects of experimental uveitis on anterior uveal prostaglandin transport and aqueous humor composition . Invest Ophthalmol Vis Sci 1974;13:959-966. 23. Howes EL Jr, Rosenbaum JT, Cruse VK: Ocular inflammation induced by intravitreal endotoxin (LPS) is enhanced in LPS tolerant rabbits , abstracted. Invest Ophthalmol Vis Sci 1984;25( (suppl) ):29. 24. Howes EL Jr, Wong KL, Hartiala KT, et al: Complement and polymorphonuclear leukocytes do not determine the vascular permeability induced by intraocular LPS. Am J Pathol, in press. 25. Skarnes RC, Braan SK, Hull SS, et al: Role of prostaglandin E in the biphasic fever response to endotoxin . J Exp Med 1981;154:112-122.Crossref 26. Sraer JD, Moulonguet-Doleris L, Delarue F, et al: Prostaglandin synthesis by glomeruli isolated from rats with glycerol-induced acute renal failure . Circ Res 1981;49:775-783.Crossref 27. Andrews C, Nolan JP, Venuto RC: Effects of endotoxin tolerance on the hemodynamic changes associated with glycerol administration . Nephron 1981;28:141-144.Crossref 28. Wahl LM, Rosenstreich DL, Glove LM, et al: Defective prostaglandin synthesis by C3H/HeJ macrophage stimulated with endotoxin preparations . Infect Immun 1979;23:8-13.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Feb 1, 1985

References