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Lipoid Cell Tumor of the Ovary: A Cause of Virilization in Girls

Lipoid Cell Tumor of the Ovary: A Cause of Virilization in Girls Abstract Sir.—The evaluation of prepubertal girls with virilization entails detailed biochemical study. Although the androgens causing the virilization may be identified by analyzing urine and plasma, the source of the increased androgen production frequently remains obscure. Herein we describe two virilized prepubertal girls who had lipoid cell tumors of the ovary. These patients emphasize the necessity of abdominal imaging to appropriately establish the source of abnormal steroid production. Virilization of prepubertal girls that is not due to congenital virilizing adrenal hyperplasia is usually caused by androgens arising from an abnormality of the adrenal glands or ovaries. While analysis of urine and plasma may identify the androgen(s) causing the virilization, the anatomic origin of the abnormality frequently cannot be specifically localized by biochemical methods or physical examination. Therefore, abdominal imaging techniques may be necessary to localize and characterize the anatomic abnormality. Two prepubertal girls who experienced virilization caused by lipoid cell References 1. Case 22-1982, Case Records of the Massachusetts General Hospital: Weekly clinicopathologic exercises . N Engl J Med 1982;306: 1348-1355.Crossref 2. Rosenfield RL: The ovary and female sexual maturation , in Kaplan SA (ed): Clinical Pediatric and Adolescent Endocrinology . Philadelphia, WB Saunders Co, 1982, pp 217-268. 3. Ammann AJ, Kaufman S, Gilbert A: Virilizing ovarian tumor in a 2½-year-old girl . J Pediatr 1967;70:782-787.Crossref 4. Towne BH, Mahour GH, Wooley MM, et al: Ovarian cysts and tumors in infancy and children . J Pediatr Surg 1975;10:311-320.Crossref 5. Breen JL, Maxson WS: Ovarian tumors in children and adolescents . Clin Obstet Gynecol 1977;20:607-623.Crossref 6. Scully RE: Tumors of the Ovary and Maldeveloped Gonads . Atlas of Tumor Pathology, Washington, DC, Armed Forces Institute of Pathology, 1979, ser 2, fasc 16, pp 190-208, 212-225, 287-299. 7. Altman AJ, Schwartz AD: Malignant Diseases of Infancy, Childhood and Adolescence , ed 2. Philadelphia, WB Saunders Co, 1983, p 497. 8. Camacho AM, Migeon CJ: Isolation, identification and quantitation of testosterone in the urine of normal adults and in patients with endocrine disorders . J Clin Endocrinol 1963;23: 301-305.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1987.04460070018005
Publisher site
See Article on Publisher Site

Abstract

Abstract Sir.—The evaluation of prepubertal girls with virilization entails detailed biochemical study. Although the androgens causing the virilization may be identified by analyzing urine and plasma, the source of the increased androgen production frequently remains obscure. Herein we describe two virilized prepubertal girls who had lipoid cell tumors of the ovary. These patients emphasize the necessity of abdominal imaging to appropriately establish the source of abnormal steroid production. Virilization of prepubertal girls that is not due to congenital virilizing adrenal hyperplasia is usually caused by androgens arising from an abnormality of the adrenal glands or ovaries. While analysis of urine and plasma may identify the androgen(s) causing the virilization, the anatomic origin of the abnormality frequently cannot be specifically localized by biochemical methods or physical examination. Therefore, abdominal imaging techniques may be necessary to localize and characterize the anatomic abnormality. Two prepubertal girls who experienced virilization caused by lipoid cell References 1. Case 22-1982, Case Records of the Massachusetts General Hospital: Weekly clinicopathologic exercises . N Engl J Med 1982;306: 1348-1355.Crossref 2. Rosenfield RL: The ovary and female sexual maturation , in Kaplan SA (ed): Clinical Pediatric and Adolescent Endocrinology . Philadelphia, WB Saunders Co, 1982, pp 217-268. 3. Ammann AJ, Kaufman S, Gilbert A: Virilizing ovarian tumor in a 2½-year-old girl . J Pediatr 1967;70:782-787.Crossref 4. Towne BH, Mahour GH, Wooley MM, et al: Ovarian cysts and tumors in infancy and children . J Pediatr Surg 1975;10:311-320.Crossref 5. Breen JL, Maxson WS: Ovarian tumors in children and adolescents . Clin Obstet Gynecol 1977;20:607-623.Crossref 6. Scully RE: Tumors of the Ovary and Maldeveloped Gonads . Atlas of Tumor Pathology, Washington, DC, Armed Forces Institute of Pathology, 1979, ser 2, fasc 16, pp 190-208, 212-225, 287-299. 7. Altman AJ, Schwartz AD: Malignant Diseases of Infancy, Childhood and Adolescence , ed 2. Philadelphia, WB Saunders Co, 1983, p 497. 8. Camacho AM, Migeon CJ: Isolation, identification and quantitation of testosterone in the urine of normal adults and in patients with endocrine disorders . J Clin Endocrinol 1963;23: 301-305.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Jul 1, 1987

References