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Lipids in Cerebrospinal Fluid: XII. In Multiple Sclerosis and Retrobulbar Neuritis

Lipids in Cerebrospinal Fluid: XII. In Multiple Sclerosis and Retrobulbar Neuritis Abstract THE CONCEPT that cerebrospinal fluid (CSF) may contain products of central nervous system (CNS) disintegration or metabolism was discussed as early as 1910 by Mott1 and later more extensively by Mestrezat.2 The basis for these authors' suggestion was the fact that the lipid content of nervous tissue was high. For this reason the quantitative determination of lipids in the CSF may serve as a diagnostic test in demyelinating diseases, such as multiple sclerosis (MS). In an earlier publication from this laboratory we have outlined a scheme for the determination of lipids in the CSF and described the normal lipid profile.3 In another report we have described our preliminary findings of alterations in the CSF lipid profile in MS.4 At this time, we present a detailed summary of our findings of the changes in the CSF lipid profile in patients with MS and with retrobulbar neuritis. Methods References 1. Mott, F.W.: The Oliver-Sharpey Lectures on the Cerebro-spinal Fluid , Lancet 2:1-8, 79-83 ( (July 2 and 9) ) 1910. 2. Mestrezat, W.: Le liquide céphalo-rachidien normal et pathologique, valeur clinique de l'examen chimique: Syndromes humoraux dans les diverses affections , Paris: A. Maloine, 1912. 3. Tourtellotte, W.W.: A Study of Lipids in Cerebrospinal Fluid: VI. The Normal Lipid Profile , Neurology 9:375-383 ( (June) ) 1959.Crossref 4. Tourtellotte, W.W., and Haerer, A.F.: A Study of Lipids in the Cerebrospinal Fluid: XI. In Multiple Sclerosis , Neurology 14:256 ( (March) ) 1964.Crossref 5. Tourtellotte, W.W.: " A Selected Review of Reactions of the Cerebrospinal Fluid to Disease ," in Fields, W.S. (ed.): Neurological Diagnostic Techniques , Springfield, Ill: Charles C Thomas, Publisher, 1966, pp 25-50. 6. Tourtellotte, W.W., and Parker, J.A.: Multiple Sclerosis: Correlation Between Immunoglobulin-G in Cerebrospinal Fluid and Brain , Science 154:1044-1046 ( (Nov 25) ) 1966.Crossref 7. Tourtellotte, W.W., et al: A Study of Lipids in the Cerebrospinal Fluid (and Serum): VIII. Further Comments on the Normal Lipid Profile , Univ Mich Med Cent J 28:114-126 ( (March-April) ) 1962. 8. Schumacher, G.A., et al: Problems of Experimental Trials of Therapy in Multiple Sclerosis: Report by the Panel on the Evaluation of Experimental Trials of Therapy in Multiple Sclerosis , Ann NY Acad Sci 122:552-568, 1965.Crossref 9. Tourtellotte, W.W.: " Multiple Sclerosis ," in Conn, H.F. (ed.): Current Therapy 1968 , Philadelphia: W. B. Saunders Co., 1968, pp 664-673. 10. Kurtzke, J.F.: On the Evaluation of Disability in Multiple Sclerosis , Neurology 11:686-694 ( (Aug) ) 1961.Crossref 11. Tourtellotte, W.W., and Haerer, A.F.: A Study of Lipids in the Cerebrospinal Fluid (and Serum): Present State of Knowledge in Health and Disease , Rev Neuropsiquiat 27:339-356 ( (Dec) ) 1964. 12. Niedieck, B., and Kuwert, E.: Zur Serologie der Experimentellen Allergischen Encephalomyelitis: I. Vergleich der Reaktivität von Lipidgemischen und Myelinextrakten mit den entsprechenden Antiseren im Präzipitationstest und in der Komplementbindungsreaktion , Z Immunitaetsforsch 125:470-492 ( (Dec) ) 1963. 13. McArdle, B., and Zilkha, K.J.: The Phospholipid Composition of Cerebrospinal Fluid in Neurological Disorders , Brain 85:389-402 ( (pt 2) ) 1962.Crossref 14. Zilkha, K.J., and McArdle, B.: The Phospholipid Composition of Cerebrospinal Fluid in Diseases Associated With Demyelination , Quart J Med 32:79-97 ( (April) ) 1963. 15. Tourtellotte, W.W.; DeJong, R.N.; and VanHouten, W.H.: A Study of Lipids in the Cerebrospinal Fluid: I. The Historical Aspects , Univ Mich Med Cent J 24:66-96 ( (March) ) 1958. 16. Poser, C.M., and Curran, G.L.: Cerebrospinal Fluid Free Cholesterol as Index of Activity of Multiple Sclerosis and Allied Diseases , Arch Neurol Psychiat 80:304-313 ( (Sept) ) 1958.Crossref 17. Green, J.B., et al: The Cholesterol and Cholesterol Ester Content of Cerebrospinal Fluid in Patients With Multiple Sclerosis and Other Neurological Diseases , J Neurol Neurosurg Psychiat 22:117-119 ( (May) ) 1959.Crossref 18. Plum, C.M.: Biochemical Studies of the Composition of Cerebrospinal Fluid in Multiple Sclerosis , Int J Neurol 2:121-148 ( (No. 2) ) 1961. 19. Plum, C.M.: The Cholesterol Content of Cerebrospinal Fluid With Special Regard to the Occurrence in Cases With Multiple Sclerosis , Acta Psychiat Neurol Scand 148( (suppl) ):79-100, 1960.Crossref 20. Phillips, B.M., and Robinson, N.: Quantitative Thin Layer Chromatography of Cerebrospinal Fluid Phospholipids , Clin Chim Acta 8:832-842 ( (Nov) ) 1963.Crossref 21. Christensen Lou, H.O., and Matzke, J.: Cerebroside and Other Polar Lipids of the Cerebrospinal Fluid in Neurological Diseases , Acta Neurol Scand 41:445-447 ( (No. 4) ) 1965.Crossref 22. Alling, C.: Chromatographic Studies of the Lipids in Cerebrospinal Fluid (CSF) , Acta Neurol Scand 13( (pt 1) ):143-148, 1965. 23. Pilz, H.: Eine Mikromethode zur Bestimmung der Gesamtlipoide, des Cholesterins und des Lipoidphosphors im Liquor cerebrospinalis , Klin Wschr 45:422-425 ( (April 15) ) 1967.Crossref 24. Farstad, M.: Determination of Fatty Acids in the Cerebrospinal Fluid: IV. The Fatty Acid Content of the Major Lipid Fractions and the Total Fatty Acid Esters of Cerebrospinal Fluid , Scand J Clin Lab Invest 17:336-340 ( (No. 4) ) 1965.Crossref 25. VanSande, M., and Bokonjic, R.: " Separation quantitative des esters de cholesterol dans le liquide céphalo-rachidien humain par chromatographie en couche mince: Techniques et resultats ," in Sayk, J. (ed.): Symposiom über die Zerebrospinalflüssigkeit , Jena: G. Fischer, 1966, p 49. 26. Pilz, H., and Frick, E.: Dünnschichtchromatographische Lipoidmuster vom normalen menschlichen Serum und Liquor cerebrospinalis , Klin Wschr 44:780-786 ( (July 1) ) 1966.Crossref 27. Tichy, J.: Cholesterol in the Cerebrospinal Fluid: An Analysis of 447 Neurological Patients , Rev Czech Med 12:265-271 ( (No. 4) ) 1966. 28. Gerstl, B., et al: Alterations in Myelin Fatty Acids and Plasmalogens in Multiple Sclerosis , Ann NY Acad Sci 122:405-416, 1965.Crossref 29. Tourtellotte, W.W.; Parker, J.A.; and Itabashi, H.H.: Some Spaces and Barriers in Postmortem Multiple Sclerosis , Progr Brain Res 29:493-525, 1968. 30. Haerer, A.F., et al: A Study of the Blood-Cerebrospinal Fluid-Brain Barrier in Multiple Sclerosis: I. Blood-Cerebrospinal Fluid Barrier to Sodium Bromide , Neurology 14:345-354 ( (April) ) 1964.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Lipids in Cerebrospinal Fluid: XII. In Multiple Sclerosis and Retrobulbar Neuritis

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American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
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0003-9942
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1538-3687
DOI
10.1001/archneur.1969.00480120051004
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Abstract

Abstract THE CONCEPT that cerebrospinal fluid (CSF) may contain products of central nervous system (CNS) disintegration or metabolism was discussed as early as 1910 by Mott1 and later more extensively by Mestrezat.2 The basis for these authors' suggestion was the fact that the lipid content of nervous tissue was high. For this reason the quantitative determination of lipids in the CSF may serve as a diagnostic test in demyelinating diseases, such as multiple sclerosis (MS). In an earlier publication from this laboratory we have outlined a scheme for the determination of lipids in the CSF and described the normal lipid profile.3 In another report we have described our preliminary findings of alterations in the CSF lipid profile in MS.4 At this time, we present a detailed summary of our findings of the changes in the CSF lipid profile in patients with MS and with retrobulbar neuritis. Methods References 1. Mott, F.W.: The Oliver-Sharpey Lectures on the Cerebro-spinal Fluid , Lancet 2:1-8, 79-83 ( (July 2 and 9) ) 1910. 2. Mestrezat, W.: Le liquide céphalo-rachidien normal et pathologique, valeur clinique de l'examen chimique: Syndromes humoraux dans les diverses affections , Paris: A. Maloine, 1912. 3. Tourtellotte, W.W.: A Study of Lipids in Cerebrospinal Fluid: VI. The Normal Lipid Profile , Neurology 9:375-383 ( (June) ) 1959.Crossref 4. Tourtellotte, W.W., and Haerer, A.F.: A Study of Lipids in the Cerebrospinal Fluid: XI. In Multiple Sclerosis , Neurology 14:256 ( (March) ) 1964.Crossref 5. Tourtellotte, W.W.: " A Selected Review of Reactions of the Cerebrospinal Fluid to Disease ," in Fields, W.S. (ed.): Neurological Diagnostic Techniques , Springfield, Ill: Charles C Thomas, Publisher, 1966, pp 25-50. 6. Tourtellotte, W.W., and Parker, J.A.: Multiple Sclerosis: Correlation Between Immunoglobulin-G in Cerebrospinal Fluid and Brain , Science 154:1044-1046 ( (Nov 25) ) 1966.Crossref 7. Tourtellotte, W.W., et al: A Study of Lipids in the Cerebrospinal Fluid (and Serum): VIII. Further Comments on the Normal Lipid Profile , Univ Mich Med Cent J 28:114-126 ( (March-April) ) 1962. 8. Schumacher, G.A., et al: Problems of Experimental Trials of Therapy in Multiple Sclerosis: Report by the Panel on the Evaluation of Experimental Trials of Therapy in Multiple Sclerosis , Ann NY Acad Sci 122:552-568, 1965.Crossref 9. Tourtellotte, W.W.: " Multiple Sclerosis ," in Conn, H.F. (ed.): Current Therapy 1968 , Philadelphia: W. B. Saunders Co., 1968, pp 664-673. 10. Kurtzke, J.F.: On the Evaluation of Disability in Multiple Sclerosis , Neurology 11:686-694 ( (Aug) ) 1961.Crossref 11. Tourtellotte, W.W., and Haerer, A.F.: A Study of Lipids in the Cerebrospinal Fluid (and Serum): Present State of Knowledge in Health and Disease , Rev Neuropsiquiat 27:339-356 ( (Dec) ) 1964. 12. Niedieck, B., and Kuwert, E.: Zur Serologie der Experimentellen Allergischen Encephalomyelitis: I. Vergleich der Reaktivität von Lipidgemischen und Myelinextrakten mit den entsprechenden Antiseren im Präzipitationstest und in der Komplementbindungsreaktion , Z Immunitaetsforsch 125:470-492 ( (Dec) ) 1963. 13. McArdle, B., and Zilkha, K.J.: The Phospholipid Composition of Cerebrospinal Fluid in Neurological Disorders , Brain 85:389-402 ( (pt 2) ) 1962.Crossref 14. Zilkha, K.J., and McArdle, B.: The Phospholipid Composition of Cerebrospinal Fluid in Diseases Associated With Demyelination , Quart J Med 32:79-97 ( (April) ) 1963. 15. Tourtellotte, W.W.; DeJong, R.N.; and VanHouten, W.H.: A Study of Lipids in the Cerebrospinal Fluid: I. The Historical Aspects , Univ Mich Med Cent J 24:66-96 ( (March) ) 1958. 16. Poser, C.M., and Curran, G.L.: Cerebrospinal Fluid Free Cholesterol as Index of Activity of Multiple Sclerosis and Allied Diseases , Arch Neurol Psychiat 80:304-313 ( (Sept) ) 1958.Crossref 17. Green, J.B., et al: The Cholesterol and Cholesterol Ester Content of Cerebrospinal Fluid in Patients With Multiple Sclerosis and Other Neurological Diseases , J Neurol Neurosurg Psychiat 22:117-119 ( (May) ) 1959.Crossref 18. Plum, C.M.: Biochemical Studies of the Composition of Cerebrospinal Fluid in Multiple Sclerosis , Int J Neurol 2:121-148 ( (No. 2) ) 1961. 19. Plum, C.M.: The Cholesterol Content of Cerebrospinal Fluid With Special Regard to the Occurrence in Cases With Multiple Sclerosis , Acta Psychiat Neurol Scand 148( (suppl) ):79-100, 1960.Crossref 20. Phillips, B.M., and Robinson, N.: Quantitative Thin Layer Chromatography of Cerebrospinal Fluid Phospholipids , Clin Chim Acta 8:832-842 ( (Nov) ) 1963.Crossref 21. Christensen Lou, H.O., and Matzke, J.: Cerebroside and Other Polar Lipids of the Cerebrospinal Fluid in Neurological Diseases , Acta Neurol Scand 41:445-447 ( (No. 4) ) 1965.Crossref 22. Alling, C.: Chromatographic Studies of the Lipids in Cerebrospinal Fluid (CSF) , Acta Neurol Scand 13( (pt 1) ):143-148, 1965. 23. Pilz, H.: Eine Mikromethode zur Bestimmung der Gesamtlipoide, des Cholesterins und des Lipoidphosphors im Liquor cerebrospinalis , Klin Wschr 45:422-425 ( (April 15) ) 1967.Crossref 24. Farstad, M.: Determination of Fatty Acids in the Cerebrospinal Fluid: IV. The Fatty Acid Content of the Major Lipid Fractions and the Total Fatty Acid Esters of Cerebrospinal Fluid , Scand J Clin Lab Invest 17:336-340 ( (No. 4) ) 1965.Crossref 25. VanSande, M., and Bokonjic, R.: " Separation quantitative des esters de cholesterol dans le liquide céphalo-rachidien humain par chromatographie en couche mince: Techniques et resultats ," in Sayk, J. (ed.): Symposiom über die Zerebrospinalflüssigkeit , Jena: G. Fischer, 1966, p 49. 26. Pilz, H., and Frick, E.: Dünnschichtchromatographische Lipoidmuster vom normalen menschlichen Serum und Liquor cerebrospinalis , Klin Wschr 44:780-786 ( (July 1) ) 1966.Crossref 27. Tichy, J.: Cholesterol in the Cerebrospinal Fluid: An Analysis of 447 Neurological Patients , Rev Czech Med 12:265-271 ( (No. 4) ) 1966. 28. Gerstl, B., et al: Alterations in Myelin Fatty Acids and Plasmalogens in Multiple Sclerosis , Ann NY Acad Sci 122:405-416, 1965.Crossref 29. Tourtellotte, W.W.; Parker, J.A.; and Itabashi, H.H.: Some Spaces and Barriers in Postmortem Multiple Sclerosis , Progr Brain Res 29:493-525, 1968. 30. Haerer, A.F., et al: A Study of the Blood-Cerebrospinal Fluid-Brain Barrier in Multiple Sclerosis: I. Blood-Cerebrospinal Fluid Barrier to Sodium Bromide , Neurology 14:345-354 ( (April) ) 1964.Crossref

Journal

Archives of Neurology – American Medical Association

Published: Jun 1, 1969

References

  • The Oliver-Sharpey Lectures on the Cerebro-spinal Fluid
    Mott , F.W.
  • Le liquide céphalo-rachidien normal et pathologique, valeur clinique de l'examen chimique: Syndromes humoraux dans les diverses affections
    Mestrezat , W.
  • A Study of Lipids in Cerebrospinal Fluid: VI. The Normal Lipid Profile
    Tourtellotte , W.W.
  • A Study of Lipids in the Cerebrospinal Fluid: XI. In Multiple Sclerosis
    Tourtellotte , W.W., and Haerer, A.F.
  • Neurological Diagnostic Techniques
    Tourtellotte , W.W.: "
  • Multiple Sclerosis: Correlation Between Immunoglobulin-G in Cerebrospinal Fluid and Brain
    Tourtellotte , W.W., and Parker, J.A.
  • A Study of Lipids in the Cerebrospinal Fluid (and Serum): VIII. Further Comments on the Normal Lipid Profile
    Tourtellotte , W.W., et al
  • Problems of Experimental Trials of Therapy in Multiple Sclerosis: Report by the Panel on the Evaluation of Experimental Trials of Therapy in Multiple Sclerosis
    Schumacher , G.A., et al
  • Current Therapy 1968
    Tourtellotte , W.W.: "
  • On the Evaluation of Disability in Multiple Sclerosis
    Kurtzke , J.F.
  • A Study of Lipids in the Cerebrospinal Fluid (and Serum): Present State of Knowledge in Health and Disease
    Tourtellotte , W.W., and Haerer, A.F.
  • Zur Serologie der Experimentellen Allergischen Encephalomyelitis: I. Vergleich der Reaktivität von Lipidgemischen und Myelinextrakten mit den entsprechenden Antiseren im Präzipitationstest und in der Komplementbindungsreaktion
    Niedieck , B., and Kuwert, E.
  • The Phospholipid Composition of Cerebrospinal Fluid in Neurological Disorders
    McArdle , B., and Zilkha, K.J.
  • The Phospholipid Composition of Cerebrospinal Fluid in Diseases Associated With Demyelination
    Zilkha , K.J., and McArdle, B.
  • A Study of Lipids in the Cerebrospinal Fluid: I. The Historical Aspects
    Tourtellotte , W.W.; DeJong, R.N.; and VanHouten, W.H.
  • Cerebrospinal Fluid Free Cholesterol as Index of Activity of Multiple Sclerosis and Allied Diseases
    Poser , C.M., and Curran, G.L.
  • The Cholesterol and Cholesterol Ester Content of Cerebrospinal Fluid in Patients With Multiple Sclerosis and Other Neurological Diseases
    Green , J.B., et al
  • Biochemical Studies of the Composition of Cerebrospinal Fluid in Multiple Sclerosis
    Plum , C.M.
  • The Cholesterol Content of Cerebrospinal Fluid With Special Regard to the Occurrence in Cases With Multiple Sclerosis
    Plum , C.M.
  • Quantitative Thin Layer Chromatography of Cerebrospinal Fluid Phospholipids
    Phillips , B.M., and Robinson, N.
  • Cerebroside and Other Polar Lipids of the Cerebrospinal Fluid in Neurological Diseases
    Christensen Lou , H.O., and Matzke, J.
  • Chromatographic Studies of the Lipids in Cerebrospinal Fluid (CSF)
    Alling , C.
  • Eine Mikromethode zur Bestimmung der Gesamtlipoide, des Cholesterins und des Lipoidphosphors im Liquor cerebrospinalis
    Pilz , H.
  • Determination of Fatty Acids in the Cerebrospinal Fluid: IV. The Fatty Acid Content of the Major Lipid Fractions and the Total Fatty Acid Esters of Cerebrospinal Fluid
    Farstad , M.
  • Symposiom über die Zerebrospinalflüssigkeit
    VanSande , M., and Bokonjic, R.: "
  • Dünnschichtchromatographische Lipoidmuster vom normalen menschlichen Serum und Liquor cerebrospinalis
    Pilz , H., and Frick, E.
  • Cholesterol in the Cerebrospinal Fluid: An Analysis of 447 Neurological Patients
    Tichy , J.
  • Alterations in Myelin Fatty Acids and Plasmalogens in Multiple Sclerosis
    Gerstl , B., et al
  • Some Spaces and Barriers in Postmortem Multiple Sclerosis
    Tourtellotte , W.W.; Parker, J.A.; and Itabashi, H.H.
  • A Study of the Blood-Cerebrospinal Fluid-Brain Barrier in Multiple Sclerosis: I. Blood-Cerebrospinal Fluid Barrier to Sodium Bromide
    Haerer , A.F., et al

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