Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Lipid Peroxides and Superoxide Dismutase Activity in Trichophyte Lesions

Lipid Peroxides and Superoxide Dismutase Activity in Trichophyte Lesions Abstract To the Editor.— In recent years, reactipve oxygen species and lipid peroxides that are produced from reactive oxygen species in the presence of polyunsaturated fatty acids have been implicated in the pathogenesis of many inflammatory disorders, including dermatologic diseases. On the other hand, superoxide dismutase (SOD), catalase, and glutathione peroxidase, all of which effectively remove reactive oxygen species or inhibit lipid peroxidation, serve to protect the host from oxidative tissue injury. We have demonstrated elevated lipid peroxide levels in ulcerated burns, wounds, and other erosive skin lesions, and have found that individual variation in the capacity for SOD induction to scavenge reactive oxygen species or inhibit lipid peroxidation correlates well with the capacity for healing in inflammatory skin diseases.1,2 More recently, we have also suggested that the SOD induction capacity assessed by human leukocytes and the toxic herbicide, paraquat, can predict longevity and carcinogenesis in humans.3In order References 1. Niwa Y, Kanoh T, Sakane T, Soh H, Kawai S, Miyachi Y. The ratio of lipid peroxides to superoxide dismutase activity in the skin lesions of patients with severe skin diseases: an accurate prognostic indicator . Life Sci. 1987;40:921-927.Crossref 2. Niwa Y, Kasama T, Kawai S, et al. The effect of aging on cutaneous lipid peroxide levels and superoxide dismutase activity in guinea pigs and patients with burns . Life Sci. 1988;42:351-356.Crossref 3. Niwa Y, Ishimoto K, Kanoh T. Induction of superoxide dismutase in leukocytes by paraquat: correlation with age and possible predictor of longevity . Blood. 1990;76:835-841. 4. Kawai S, Komura J, Asada Y, Niwa Y. Experimental burn-induced changes in lipid peroxide levels, and activity of superoxide dismutase and glutathione peroxidase in skin lesions, serum, and liver of mice . Arch Dermatol Res. 1988;280:171-175.Crossref 5. Tagami H, Watanabe S, Ofuji S. Trichophytin contact sensitivity in guinea pigs with experimental dermatophytosis induced by a new inoculation . J Invest Dermatol. 1973;61:237-241.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Lipid Peroxides and Superoxide Dismutase Activity in Trichophyte Lesions

Loading next page...
 
/lp/american-medical-association/lipid-peroxides-and-superoxide-dismutase-activity-in-trichophyte-pdijmU1rCo
Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1991.01680070143028
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— In recent years, reactipve oxygen species and lipid peroxides that are produced from reactive oxygen species in the presence of polyunsaturated fatty acids have been implicated in the pathogenesis of many inflammatory disorders, including dermatologic diseases. On the other hand, superoxide dismutase (SOD), catalase, and glutathione peroxidase, all of which effectively remove reactive oxygen species or inhibit lipid peroxidation, serve to protect the host from oxidative tissue injury. We have demonstrated elevated lipid peroxide levels in ulcerated burns, wounds, and other erosive skin lesions, and have found that individual variation in the capacity for SOD induction to scavenge reactive oxygen species or inhibit lipid peroxidation correlates well with the capacity for healing in inflammatory skin diseases.1,2 More recently, we have also suggested that the SOD induction capacity assessed by human leukocytes and the toxic herbicide, paraquat, can predict longevity and carcinogenesis in humans.3In order References 1. Niwa Y, Kanoh T, Sakane T, Soh H, Kawai S, Miyachi Y. The ratio of lipid peroxides to superoxide dismutase activity in the skin lesions of patients with severe skin diseases: an accurate prognostic indicator . Life Sci. 1987;40:921-927.Crossref 2. Niwa Y, Kasama T, Kawai S, et al. The effect of aging on cutaneous lipid peroxide levels and superoxide dismutase activity in guinea pigs and patients with burns . Life Sci. 1988;42:351-356.Crossref 3. Niwa Y, Ishimoto K, Kanoh T. Induction of superoxide dismutase in leukocytes by paraquat: correlation with age and possible predictor of longevity . Blood. 1990;76:835-841. 4. Kawai S, Komura J, Asada Y, Niwa Y. Experimental burn-induced changes in lipid peroxide levels, and activity of superoxide dismutase and glutathione peroxidase in skin lesions, serum, and liver of mice . Arch Dermatol Res. 1988;280:171-175.Crossref 5. Tagami H, Watanabe S, Ofuji S. Trichophytin contact sensitivity in guinea pigs with experimental dermatophytosis induced by a new inoculation . J Invest Dermatol. 1973;61:237-241.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Aug 1, 1991

References