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Lipid Metabolism in Non-Insulin-Dependent Diabetes Mellitus: Effect of Glipizide Therapy

Lipid Metabolism in Non-Insulin-Dependent Diabetes Mellitus: Effect of Glipizide Therapy Abstract • Plasma lipid concentration and lipoprotein composition were studied before and after several months of glipizide treatment in 23 patients with non-insulin-dependent diabetes mellitus. The mean (±SEM) plasma glucose level fell 87 mg/dL, and the fall in plasma glucose concentration was correlated with a reduction in plasma triglyceride, very low-density lipoprotein triglyceride, cholesterol, and low-density lipoprotein cholesterol levels. Furthermore, there was a statistically significant increase in the plasma high-density lipoprotein cholesterol to total cholesterol ratio. Thus, improved diabetic control in patients treated with glipizide with non-insulin-dependent diabetes mellitus leads to changes in lipoprotein metabolism thought to be beneficial in terms of known cardiovascular risk factors. (Arch Intern Med 1982;142:1498-1500) References 1. Kimi CR, Knatterud GL, Meinert CL, et al: The University Group Diabetes Program: A study of the effect of hypoglycemic agents on vascular complications in patients with adult-onset diabetes: I. Design, methods and baseline characteristics. II. Mortality results. Diabetes 1970;19( (suppl 2) ):474-830. 2. The UGDP controversy, Scientific Advisory Panel of the Executive Committee, American Diabetes Association. Diabetes 1979;28:168-170.Crossref 3. Report of the Committee for the Assessment of Biometric Aspects of Controlled Trials of Hypoglycemic Agents. JAMA 1975;231:583-608.Crossref 4. Eaton RP: Lipids and diabetes: The case for treatment of macrovascular disease. Diabetes Care 1979;2:46-50. 5. Goldberg RB: Lipid disorders in diabetes. Diabetes Care 1981;4:561-572.Crossref 6. Kannel WB, Castelli WP, Gordon T, et al: Serum cholesterol, lipoproteins, and the risk of coronary heart disease: The Framingham Study. Ann Intern Med 1971;74:1-12.Crossref 7. Miller GJ, Miller NE: Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. Lancet 1975;1:16-19.Crossref 8. Carlson LA, Bottiger LE, Ahfeldt PE: Risk factors for myocardial infarction in the Stockholm prospective study: A 14-year follow-up focusing on the role of plasma triglycerides and cholesterol. Acta Med Scand 1979;206:351-360.Crossref 9. Lisch HJ, Sailer S: Lipoprotein patterns in diet, sulphonylurea, and insulin treated diabetics. Diabetologia 1981;20:118-122.Crossref 10. Kadish AH, Litle RL, Sternberg JC: A new and rapid method for determining of glucose by measurement of rate of oxygen consumption. Clin Chem 1968;14:116-131. 11. Wahlfeld AW: Triglyceride determination after enzymatic hydrolysis , in Bergmeyer HU (ed): Methods of Enzymatic Analysis , ed 2. New York, Academic Press Inc, 1974, pp 1831-1835. 12. Allain CC, Poon LS, Chan CSG, et al: Enzymatic determination of total serum cholesterol. Clin Chem 1974;20:470-475. 13. Burstein M, Scholnick HR, Morfin R: Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J Lipid Res 1970;11:583-595. 14. Havel RJ, Eder HS, Bragdon JH: The distribution and chemical composition of ultracentrifugally-separated lipoproteins in human serum. J Clin Invest 1955;34:1345-1353.Crossref 15. Radding CM, Steinberg D: Studies on the synthesis and secretion of serum lipoproteins by rat liver slices. J Clin Invest 1960;39:1560-1569.Crossref 16. Hull CH, Nie NH: SPSS Update 7-9 . New York, McGraw-Hill Book Co, 1981, pp 220-239. 17. Brogden RN, Heel RC, Pakes GE, et al: Glipizide: A review of its pharmacological properties and therapeutic use. Drugs 1979;18:329-353.Crossref 18. Williams P, Robinson D, Bailey A: High-density lipoprotein and coronary risk factors in normal men. Lancet 1979;1:72-75.Crossref 19. Castelli WP, Doyle JT, Gordon T, et al: HDL cholesterol and other lipids in coronary heart disease. Circulation 1977;55:767-772.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Lipid Metabolism in Non-Insulin-Dependent Diabetes Mellitus: Effect of Glipizide Therapy

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1982.00340210094019
Publisher site
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Abstract

Abstract • Plasma lipid concentration and lipoprotein composition were studied before and after several months of glipizide treatment in 23 patients with non-insulin-dependent diabetes mellitus. The mean (±SEM) plasma glucose level fell 87 mg/dL, and the fall in plasma glucose concentration was correlated with a reduction in plasma triglyceride, very low-density lipoprotein triglyceride, cholesterol, and low-density lipoprotein cholesterol levels. Furthermore, there was a statistically significant increase in the plasma high-density lipoprotein cholesterol to total cholesterol ratio. Thus, improved diabetic control in patients treated with glipizide with non-insulin-dependent diabetes mellitus leads to changes in lipoprotein metabolism thought to be beneficial in terms of known cardiovascular risk factors. (Arch Intern Med 1982;142:1498-1500) References 1. Kimi CR, Knatterud GL, Meinert CL, et al: The University Group Diabetes Program: A study of the effect of hypoglycemic agents on vascular complications in patients with adult-onset diabetes: I. Design, methods and baseline characteristics. II. Mortality results. Diabetes 1970;19( (suppl 2) ):474-830. 2. The UGDP controversy, Scientific Advisory Panel of the Executive Committee, American Diabetes Association. Diabetes 1979;28:168-170.Crossref 3. Report of the Committee for the Assessment of Biometric Aspects of Controlled Trials of Hypoglycemic Agents. JAMA 1975;231:583-608.Crossref 4. Eaton RP: Lipids and diabetes: The case for treatment of macrovascular disease. Diabetes Care 1979;2:46-50. 5. Goldberg RB: Lipid disorders in diabetes. Diabetes Care 1981;4:561-572.Crossref 6. Kannel WB, Castelli WP, Gordon T, et al: Serum cholesterol, lipoproteins, and the risk of coronary heart disease: The Framingham Study. Ann Intern Med 1971;74:1-12.Crossref 7. Miller GJ, Miller NE: Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. Lancet 1975;1:16-19.Crossref 8. Carlson LA, Bottiger LE, Ahfeldt PE: Risk factors for myocardial infarction in the Stockholm prospective study: A 14-year follow-up focusing on the role of plasma triglycerides and cholesterol. Acta Med Scand 1979;206:351-360.Crossref 9. Lisch HJ, Sailer S: Lipoprotein patterns in diet, sulphonylurea, and insulin treated diabetics. Diabetologia 1981;20:118-122.Crossref 10. Kadish AH, Litle RL, Sternberg JC: A new and rapid method for determining of glucose by measurement of rate of oxygen consumption. Clin Chem 1968;14:116-131. 11. Wahlfeld AW: Triglyceride determination after enzymatic hydrolysis , in Bergmeyer HU (ed): Methods of Enzymatic Analysis , ed 2. New York, Academic Press Inc, 1974, pp 1831-1835. 12. Allain CC, Poon LS, Chan CSG, et al: Enzymatic determination of total serum cholesterol. Clin Chem 1974;20:470-475. 13. Burstein M, Scholnick HR, Morfin R: Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J Lipid Res 1970;11:583-595. 14. Havel RJ, Eder HS, Bragdon JH: The distribution and chemical composition of ultracentrifugally-separated lipoproteins in human serum. J Clin Invest 1955;34:1345-1353.Crossref 15. Radding CM, Steinberg D: Studies on the synthesis and secretion of serum lipoproteins by rat liver slices. J Clin Invest 1960;39:1560-1569.Crossref 16. Hull CH, Nie NH: SPSS Update 7-9 . New York, McGraw-Hill Book Co, 1981, pp 220-239. 17. Brogden RN, Heel RC, Pakes GE, et al: Glipizide: A review of its pharmacological properties and therapeutic use. Drugs 1979;18:329-353.Crossref 18. Williams P, Robinson D, Bailey A: High-density lipoprotein and coronary risk factors in normal men. Lancet 1979;1:72-75.Crossref 19. Castelli WP, Doyle JT, Gordon T, et al: HDL cholesterol and other lipids in coronary heart disease. Circulation 1977;55:767-772.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Aug 1, 1982

References