Abstract For many years attempts have been made to ascertain the composition of arcus senilis in the cornea. The earliest examinations were qualitative ones and were performed by histological methods between 1850 and the early 1900's.1-7 For several decades subsequently, interest in arcus senilis seemed to wane. During the 1940's and 1950's, however, with the tremendous interest in the relationship of cholesterol to atherosclerosis, interest in arcus senilis was revived because of its possible relationship to cholesterol. Cogan and Kuwabara (1959),8 using histochemical and fat solubility studies, concluded that the arcus was composed primarily of cholesterol, phospholipids, and neutral fats. Andrews (1961),9 using quantitative biochemical analyses, concluded that the lipid associated with arcus senilis consists primarily of sterol ester with small amounts of neutral glycerides, sterol, and phospholipids also being present. An objection to the work of Andrews is that the controls, or corneas with no arcus, were References 1. In cases 3 and 9, only one cornea was available. Therefore, the amount of lipid present in one cornea was multiplied by a factor of two, assuming that this would then represent the total amount of a particular total lipid for two corneas, thus making it easier to compare with the rest of the samples. 2. Canton, E.: Observations on the Arcus Senilis or Fatty Degeneration of the Cornea: II , Lancet 1: 38 3. III, 1:560, 1850. 4. His, W.: Normalen und Patholsgischen Histologic der Cornea , Basel, 1856, pp 137-140. 5. Fuchs, E.: Zur Anatomie der Pinguecula , Graefe Arch Ophthal 37:143-191, 1891.Crossref 6. Leber, T.: Ueber die bandförmige Hornhauttrubüng , Ber Deutsch Ophthal Ges 26:53-64, 1897. 7. Takayasu, M.: Beiträge zur pathologische Anatomie des Arcus Senilis , Arch Augenheilk 43: 154-162, 1901. 8. Parsons, J.H.: Arcus Senilis , R.L.O.H. Rep , 15: 141-154, 1902. 9. Attias, G.: Uber Altersveranderungen des menschlichen Auges , Graefe Arch Ophthal 81:405-485, 1912.Crossref 10. Cogan, D.G., and Kuwabara, T.: Arcus Senilis , Arch Ophthal 68:553-560, 1959.Crossref 11. Andrews, J.S.: The Lipids of Arcus Senilis , Arch Ophthal 68:264-266, 1962.Crossref 12. VanHandel, E., and Zilversmit, D.B.: Micromethod for the Direct Determination of Serum Triglycerides , J Lab Clin Med 50:152-157 ( (July) ) 1957. 13. Bartlett, G.R.: Phosphorus Assay in Column Chromatography , J Biol Chem 234:466-468 ( (March) ) 1959. 14. Sperry, W.M., and Webb, M.: A Revision of the Schoenheimer-Sperry Method for Cholesterol Determination , J Biol Chem 187:97-106, 1950.
Archives of Ophthalmology – American Medical Association
Published: Sep 1, 1966
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera