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Levels of Antibodies to BP180 Correlate With Disease Activity in Bullous Pemphigoid

Levels of Antibodies to BP180 Correlate With Disease Activity in Bullous Pemphigoid EDITORIAL Levels of Antibodies to BP180 Correlate With Disease Activity in Bullous Pemphigoid HE ARTICLE by Schmidt et al in this issue passive transfer of antibodies to murine BP180 results in of the ARCHIVES is interesting and may skin lesions in mice that are similar to those occurring in have relevance to our clinical practice in human BP. It is not surprising that antibodies to BP180 the future. In order to make valuable the are pathogenic since the extracellular domain of BP180 T interpretation of their data and to under- is accessible to circulating antibodies, unlike BP230 stand the biological significance of their findings, it is which is completely intracellular. It is presently believed important to highlight the milestones in the research on that antibodies to BP230 are secondary, nonpathogenic, bullous pemphigoid (BP) during the last 15 years. and result from “epitope spreading,” an event that occurs in several autoimmune disorders in which an Unlike patients with pemphigus in whom there is a immune response to a specific epitope is slowly followed direct correlation between disease activity and pemphi- by an immune response to a neighboring epitope or gus antibody titers as detected by standard indirect molecule. The proximity http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Dermatology American Medical Association

Levels of Antibodies to BP180 Correlate With Disease Activity in Bullous Pemphigoid

Mutasim, Diya F.
JAMA Dermatology , Volume 136 (2) – Feb 1, 2000
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Publisher
American Medical Association
Copyright
Copyright 2000 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6068
eISSN
2168-6084
DOI
10.1001/archderm.136.2.253
Publisher site
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Abstract

EDITORIAL Levels of Antibodies to BP180 Correlate With Disease Activity in Bullous Pemphigoid HE ARTICLE by Schmidt et al in this issue passive transfer of antibodies to murine BP180 results in of the ARCHIVES is interesting and may skin lesions in mice that are similar to those occurring in have relevance to our clinical practice in human BP. It is not surprising that antibodies to BP180 the future. In order to make valuable the are pathogenic since the extracellular domain of BP180 T interpretation of their data and to under- is accessible to circulating antibodies, unlike BP230 stand the biological significance of their findings, it is which is completely intracellular. It is presently believed important to highlight the milestones in the research on that antibodies to BP230 are secondary, nonpathogenic, bullous pemphigoid (BP) during the last 15 years. and result from “epitope spreading,” an event that occurs in several autoimmune disorders in which an Unlike patients with pemphigus in whom there is a immune response to a specific epitope is slowly followed direct correlation between disease activity and pemphi- by an immune response to a neighboring epitope or gus antibody titers as detected by standard indirect molecule. The proximity

Journal

JAMA Dermatology – American Medical Association

Published: Feb 1, 2000

References

  • Serum levels of autoantibodies to BP180 correlate with disease activity in patients with bullous pemphigoid.
    Schmidt, E; Obe, K; Bröcker, EB; Zillikens, D
  • Bullous pemphigoid: clinical and immunologic follow-up after successful therapy.
    Ahmed, AR; Maize, JC; Provost, TT
  • Lack of predictive factors for the clinical course of bullous pemphigoid.
    Venning, VA; Wojnarowska, F
  • Skin explant culture: a reliable method for detecting pemphigoid antibodies in pemphigoid sera that are negative by standard immunofluorescence and immunoblotting.
    Mutasim, D; Vaughan, A; Supapannachart, N; Farooqui, JZ