Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

LEUKEMIC XANTHOMATOSIS

LEUKEMIC XANTHOMATOSIS WE SHOULD like to present a heretofore unknown disease, "leukemic xanthomatosis." The condition is not familial or hereditary and is characterized by the following features: Xanthomatous skin lesions of the disseminated type and normal cholesterol blood levels.Development of generalized visceral reticuloendotheliosis with increased cholesterol tissue contents, a dense argyrophilic reticulum, and the appearance of foam cells—a histological picture similar to that of Hand-Schüller-Christian disease and its variants.Deposits of foci of primitive mesenchymal cells in the affected tissues—as commonly seen in leukemia—however, with many of these cells exhibiting a foamy protoplasm due to a high cholesterol content.Leukemic blood—and bone marrow findings and a fatal course as in leukemia.Numerous inclusion bodies were found in the organs of the presented case, and a virus was considered as a possible etiological agent. In the aleukemic forms, the primitive stem cells do not differentiate into blood http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

LEUKEMIC XANTHOMATOSIS

Download PDF
19 pages

Loading next page...
 
/lp/american-medical-association/leukemic-xanthomatosis-08HF2Dp0G0

References (0)

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
American Medical Association
Copyright
Copyright © 1954 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1954.02050100045006
Publisher site
See Article on Publisher Site

Abstract

WE SHOULD like to present a heretofore unknown disease, "leukemic xanthomatosis." The condition is not familial or hereditary and is characterized by the following features: Xanthomatous skin lesions of the disseminated type and normal cholesterol blood levels.Development of generalized visceral reticuloendotheliosis with increased cholesterol tissue contents, a dense argyrophilic reticulum, and the appearance of foam cells—a histological picture similar to that of Hand-Schüller-Christian disease and its variants.Deposits of foci of primitive mesenchymal cells in the affected tissues—as commonly seen in leukemia—however, with many of these cells exhibiting a foamy protoplasm due to a high cholesterol content.Leukemic blood—and bone marrow findings and a fatal course as in leukemia.Numerous inclusion bodies were found in the organs of the presented case, and a virus was considered as a possible etiological agent. In the aleukemic forms, the primitive stem cells do not differentiate into blood

Journal

American journal of diseases of children – American Medical Association

Published: Jul 1, 1954

There are no references for this article.