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LETTERER-SIWE'S DISEASE

LETTERER-SIWE'S DISEASE In reviewing the literature in an attempt to identify the condition in the case which we are here reporting, we have found that Letterer,1 in 1924 under the title "Aleukämische Retikulose (Ein Beitrag zu den proliferativen Erkrankungen des Retikuloendothelialapparates)," described the occurrence of splenohepatomegaly, associated with anemia, and a purpuric eruption in a 6 month old infant. The child died four days after admission to the hospital, and at autopsy the histologic examination revealed a unique and surprising condition. In the liver, spleen, lymph nodes, bone marrow and skin there was a proliferation of large, pale reticulo-endothelial cells, invading and replacing the normal structure of these.organs. Following the publication of Letterer's article, several quite similar cases were reported, but it was not until 1933 that Siwe,2 in describing a similar case in a 16 month old infant in an article entitled "Die Reticuloendotheliose—ein neues Krankheitsbild unter den Hepatosplenomegalien," http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1936 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1936.01970150003001
Publisher site
See Article on Publisher Site

Abstract

In reviewing the literature in an attempt to identify the condition in the case which we are here reporting, we have found that Letterer,1 in 1924 under the title "Aleukämische Retikulose (Ein Beitrag zu den proliferativen Erkrankungen des Retikuloendothelialapparates)," described the occurrence of splenohepatomegaly, associated with anemia, and a purpuric eruption in a 6 month old infant. The child died four days after admission to the hospital, and at autopsy the histologic examination revealed a unique and surprising condition. In the liver, spleen, lymph nodes, bone marrow and skin there was a proliferation of large, pale reticulo-endothelial cells, invading and replacing the normal structure of these.organs. Following the publication of Letterer's article, several quite similar cases were reported, but it was not until 1933 that Siwe,2 in describing a similar case in a 16 month old infant in an article entitled "Die Reticuloendotheliose—ein neues Krankheitsbild unter den Hepatosplenomegalien,"

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Mar 1, 1936

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