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Lethal Thyroid Carcinoma

Lethal Thyroid Carcinoma Abstract • Forty-three patients who died of thyroid carcinoma (29 well-differentiated and 14 poorly differentiated tumors) were evaluated to define the parameters that affect the lethal nature of this tumor. Differentiated, limited extent of tumor and a young age at diagnosis correlated favorably with length of survival. Sex showed a trend in favor of female patients, while specific histologic characteristics and extent of resection showed no positive correlation. Based on these findings and a review of the literature, we recommend a radical approach in the management of localized, poorly differentiated tumors. For well-differentiated cancer, resection of the thyroid gland and the paratracheal, jugular, and upper mediastinal lymph nodes is advised. (Arch Otolaryngol 104:454-455, 1978) References 1. Nishiyama RH, Dunn EL, Thompson NW: Anaplastic spindle-cell and giant-cell tumors of the thyroid gland . Cancer 30:113-127, 1972.Crossref 2. Jereb B, Stjernsward J, Lowhagen T: Anaplastic giant-cell carcinoma of the thyroid: A study of treatment and prognosis . Cancer 35:1293-1295, 1975.Crossref 3. Thomas CG: Thyroid cancer: Clinical aspects, treatment , in Werner SC (ed): The Thyroid . New York, Harper & Row Publishers Inc, 1971, pp 442-480. 4. Woolner LB: Thyroid carcinoma: Pathologic classification with data on prognosis . Sem Nucl Med 1:481-501, 1971.Crossref 5. Russell MA, Gilbert EF, Jaeschke WF: Prognostic features of thyroid cancer . Cancer 36:553-559, 1975.Crossref 6. Van Herle AJ, Uller RP: Thyroid cancer classification, clinical features, diagnosis and therapy . Pharmacol Ther C 2:215-238, 1977. 7. Buckwalter JA, Thomas CG, Freeman JB: Is childhood thyroid cancer a lethal disease? Ann Surg 181:632-639, 1975.Crossref 8. Frazell EI, Foote FW: Papillary cancer of the thyroid . Cancer 2:895-922, 1958.Crossref 9. Tollefsen HR, DeCosse JJ, Hutter RVP: Papillary carcinoma of the thyroid: A clinical and pathological study of 70 fatal cases . Cancer 17:1035-1044, 1964.Crossref 10. Ibanez ML, Russell WO, Saavedra JA, et al: Thyroid carcinoma: Biologic behavior and mortality . Cancer 21:1039-1052, 1966.Crossref 11. Harada T, Ito K, Shimaoka K, et al: Fatal thyroid carcinoma . Cancer 39:2588-2596, 1977.Crossref 12. Noguchi S, Noguchi A, Murakami N: Papillary carcinoma of the thyroid: II. Value of prophylactic lymph node excision . Cancer 26:1061-1064, 1970.Crossref 13. Lawson W, Som ML, Biller HF: Papillary adenocarcinoma of the thyroid invading the upper air passages . Ann Otol Rhinol Laryngol 86:751-755, 1977. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

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References (15)

Publisher
American Medical Association
Copyright
Copyright © 1978 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1978.00790080036009
Publisher site
See Article on Publisher Site

Abstract

Abstract • Forty-three patients who died of thyroid carcinoma (29 well-differentiated and 14 poorly differentiated tumors) were evaluated to define the parameters that affect the lethal nature of this tumor. Differentiated, limited extent of tumor and a young age at diagnosis correlated favorably with length of survival. Sex showed a trend in favor of female patients, while specific histologic characteristics and extent of resection showed no positive correlation. Based on these findings and a review of the literature, we recommend a radical approach in the management of localized, poorly differentiated tumors. For well-differentiated cancer, resection of the thyroid gland and the paratracheal, jugular, and upper mediastinal lymph nodes is advised. (Arch Otolaryngol 104:454-455, 1978) References 1. Nishiyama RH, Dunn EL, Thompson NW: Anaplastic spindle-cell and giant-cell tumors of the thyroid gland . Cancer 30:113-127, 1972.Crossref 2. Jereb B, Stjernsward J, Lowhagen T: Anaplastic giant-cell carcinoma of the thyroid: A study of treatment and prognosis . Cancer 35:1293-1295, 1975.Crossref 3. Thomas CG: Thyroid cancer: Clinical aspects, treatment , in Werner SC (ed): The Thyroid . New York, Harper & Row Publishers Inc, 1971, pp 442-480. 4. Woolner LB: Thyroid carcinoma: Pathologic classification with data on prognosis . Sem Nucl Med 1:481-501, 1971.Crossref 5. Russell MA, Gilbert EF, Jaeschke WF: Prognostic features of thyroid cancer . Cancer 36:553-559, 1975.Crossref 6. Van Herle AJ, Uller RP: Thyroid cancer classification, clinical features, diagnosis and therapy . Pharmacol Ther C 2:215-238, 1977. 7. Buckwalter JA, Thomas CG, Freeman JB: Is childhood thyroid cancer a lethal disease? Ann Surg 181:632-639, 1975.Crossref 8. Frazell EI, Foote FW: Papillary cancer of the thyroid . Cancer 2:895-922, 1958.Crossref 9. Tollefsen HR, DeCosse JJ, Hutter RVP: Papillary carcinoma of the thyroid: A clinical and pathological study of 70 fatal cases . Cancer 17:1035-1044, 1964.Crossref 10. Ibanez ML, Russell WO, Saavedra JA, et al: Thyroid carcinoma: Biologic behavior and mortality . Cancer 21:1039-1052, 1966.Crossref 11. Harada T, Ito K, Shimaoka K, et al: Fatal thyroid carcinoma . Cancer 39:2588-2596, 1977.Crossref 12. Noguchi S, Noguchi A, Murakami N: Papillary carcinoma of the thyroid: II. Value of prophylactic lymph node excision . Cancer 26:1061-1064, 1970.Crossref 13. Lawson W, Som ML, Biller HF: Papillary adenocarcinoma of the thyroid invading the upper air passages . Ann Otol Rhinol Laryngol 86:751-755, 1977.

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Aug 1, 1978

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