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Leg Ulcers Following Subcutaneous Injection of a Liquid Silicone Preparation

Leg Ulcers Following Subcutaneous Injection of a Liquid Silicone Preparation Abstract • We present an unusual case of leg ulcers occurring 23 years after the patient had received large-volume subcutaneous injections of a liquid silicone preparation into her legs for cosmetic reasons. Light microscopy of a biopsy specimen from the edge of the ulcer showed optically clear vacuoles in the dermis, together with a mixed cellular infiltrate. Scanning electron microscopic studies revealed amorphous spherules within the vacuoles, and energy-dispersive spectroscopy established the presence of silicon in these spherules. Nearby tissue not containing spherules did not show a silicon peak. This case adds to the growing documentation of morbidity associated with injections of silicone of uncertain purity. (Arch Dermatol. 1989;125:670-673) References 1. Hench LL. Biomaterials . Science . 1980;208:826-831.Crossref 2. Travis WD, Balogh K, Abraham JL. Silicone granulomas: report of three cases and review of the literature . Hum Pathol. 1985;16:19-27.Crossref 3. Piechotta FU. Silicone fluid: attractive and dangerous . Aesthetic Plast Surg. 1979;3:347-355.Crossref 4. Winer LH, Sternberg TH, Lehman R, Ashley FL. Tissue reactions to injected silicone liquids . Arch Dermatol. 1964;90:588-593.Crossref 5. McDowell F. Complications with silicones: what grade of silicone? how do we know it was silicone? Plast Reconstr Surg. 1978;61:892-895.Crossref 6. Selmanowitz VJ, Orentreich N. Medical grade fluid silicone: a monographic review . J Dermatol Surg Oncol. 1977;3:597-611.Crossref 7. Orentreich D, Orentreich N. Acne scar revision update . Dermatol Clin. 1987;5:359-368. 8. Pearl RM, Laub DR, Kaplan EN. Complications following silicone injections for augmentation of the contours of the face . Plast Reconstr Surg. 1978;61:888-891.Crossref 9. Spiera H. Scleroderma after silicone augmentation mammoplasty . JAMA. 1988;260:236-238.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Leg Ulcers Following Subcutaneous Injection of a Liquid Silicone Preparation

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Publisher
American Medical Association
Copyright
Copyright © 1989 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1989.01670170084015
Publisher site
See Article on Publisher Site

Abstract

Abstract • We present an unusual case of leg ulcers occurring 23 years after the patient had received large-volume subcutaneous injections of a liquid silicone preparation into her legs for cosmetic reasons. Light microscopy of a biopsy specimen from the edge of the ulcer showed optically clear vacuoles in the dermis, together with a mixed cellular infiltrate. Scanning electron microscopic studies revealed amorphous spherules within the vacuoles, and energy-dispersive spectroscopy established the presence of silicon in these spherules. Nearby tissue not containing spherules did not show a silicon peak. This case adds to the growing documentation of morbidity associated with injections of silicone of uncertain purity. (Arch Dermatol. 1989;125:670-673) References 1. Hench LL. Biomaterials . Science . 1980;208:826-831.Crossref 2. Travis WD, Balogh K, Abraham JL. Silicone granulomas: report of three cases and review of the literature . Hum Pathol. 1985;16:19-27.Crossref 3. Piechotta FU. Silicone fluid: attractive and dangerous . Aesthetic Plast Surg. 1979;3:347-355.Crossref 4. Winer LH, Sternberg TH, Lehman R, Ashley FL. Tissue reactions to injected silicone liquids . Arch Dermatol. 1964;90:588-593.Crossref 5. McDowell F. Complications with silicones: what grade of silicone? how do we know it was silicone? Plast Reconstr Surg. 1978;61:892-895.Crossref 6. Selmanowitz VJ, Orentreich N. Medical grade fluid silicone: a monographic review . J Dermatol Surg Oncol. 1977;3:597-611.Crossref 7. Orentreich D, Orentreich N. Acne scar revision update . Dermatol Clin. 1987;5:359-368. 8. Pearl RM, Laub DR, Kaplan EN. Complications following silicone injections for augmentation of the contours of the face . Plast Reconstr Surg. 1978;61:888-891.Crossref 9. Spiera H. Scleroderma after silicone augmentation mammoplasty . JAMA. 1988;260:236-238.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: May 1, 1989

References