Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Lead Poisoning During Pregnancy: Fetal Tolerance of Calcium Disodium Edetate

Lead Poisoning During Pregnancy: Fetal Tolerance of Calcium Disodium Edetate Abstract In the course of investigating a familial epidemic of lead poisoning due to the inhalation of fumes from burning battery cases, we had the opportunity to treat the mother of the family one month before the delivery of a normal infant.1 There have been no previous reports of calcium disodium edetate therapy during pregnancy and no mention of its effect on the fetus. Clinical observations on lead poisoning during pregnancy have been infrequent in the past 30 years. For this reason, the potential fetal toxicity of maternal lead poisoning is briefly reviewed as a preliminary to the report of this case. For over 100 years, lead poisoning in women has been considered to be associated with sterility, abortions, and high fetal and neonatal loss. In 1860, Paul2 reported that 123 pregnancies in women lead workers terminated in fetal death in 73 instances and that of the 50 live References 1. McIntire, M. S., and Angle, C. R.: Lead Poisoning in Childhood: Neurologic Sequelae , Nebraska Med J 49:412-418, 1964. 2. Paul, C.: Etude sur l'intoxication lente par les preparations de plomb; de son influence par le produit de la conception , Arch Gen Med 15: 513-533, 1860. 3. Oliver, T.: Lead Poisoning and Race , Brit Med J 1:1096, 1911.Crossref 4. Hall, H. C.: Notes on Metallic Poisoning , Texas J Med 10:308-314, 1914. 5. Holt, L. E. Jr.: Lead Poisoning in Infancy , Amer J Dis Child 25:229-233, 1923. 6. Aub, J. C., et al: Lead Poisoning , Medicine (Balt) 4:1-250, 1925. 7. Hamilton, A.: Industrial Poisons in United States , New York: The Macmillan Company, 1929, pp 8-17, 110-115. 8. Hansmann, G. H., and Perry, M. C.: Lead Absorption and Intoxication in Man Unassociated With Occupations or Industrial Hazards , Arch Path 30:226-239, 1940. 9. Cantarow, A., and Trumper, M.: Lead Poisoning , ed 1, Baltimore: The Williams & Wilkins Co., 1944. pp 84-86, 142-144. 10. Nogaki, K.: On Action of Lead on Body of Lead Refinery Workers: Particularly on Conception, Pregnancy and Parturition in Case of Females and on Vitality of Their Newborn , Acta Med (Fukuoka) 27:1314-1338, 1957; 11. abstracted, Excerpta Med (XVII) 4:2176, 1958. 12. Gillet, J. A.: Outbreak of Lead Poisoning in Canklow District of Rotherham , Lancet 1:1118-1121, 1955.Crossref 13. Travers, E.; Rendle-Short, J.; and Harvey, C. C.: Rotherham Lead-Poisoning Outbreak , Lancet 2:113-116, 1956.Crossref 14. Harvey, C. C., and Travers, E.: Personal communication to the authors. 15. Hall, A.: Increasing Use of Lead as an Abortifacient , Brit Med J 1:584-587, 1905.Crossref 16. Hall, A., and Ransom, W. B.: Plumbism From Ingestion of Diachylon as an Abortifacient , Brit Med J 1:428, 1906.Crossref 17. Pindborg, S.: Om Sølverglødforgiftning i Danmark , Ugeskr Laeg 107:1-6, 1945. 18. Hansen, A. B.: Vier Fälle von Bleivergiftung nach Einnehmen von "Silberglätte" als Abtreibungsmittel , Slg Vergift f 13:214-219, 1944. 19. Bell, W. B.: Influence of Lead on Normal and Abnormal Cell Growth , Lancet 1:268-276, 1924. 20. Karlog, O., and Moller, K. O.: Three Cases of Acute Lead Poisoning: Analyses of Organs for Lead and Observations on Polarographic Lead Determinations , Acta Pharmacol (Robenharn) 15: 8-16, 1958.Crossref 21. Laug, E. P.: Application of Dithizone Method to Determination of Lead in Biological Materials , J Ass Offic Agric Chem 21:481-487, 1938. 22. Weber, H. J.: Some Experiences With Polarographic Methods in Controlling Lead Hazard in Brass Foundries , J Industr Hyg Toxicol 29: 158-167, 1947. 23. Foreman, H. and Trujillo, T. T.: Metabolism of C14 Labeled Ethylenediamine Tetraacetic Acid in Human Beings , J Lab Clin Med 43:566-571, 1954. 24. Foreman, H.: Person communication to the authors. 25. Foreman, H.; Finegan, C.; and Lushbaugh, C. C.: Nephrotoxic Hazard From Uncontrolled Edathamil Calcium-Disodium Therapy , JAMA 160:1042-1046, 1956.Crossref 26. Smith, H. D.: Pediatric Lead Poisoning , Arch Environ Health 8:256-261, 1964.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Lead Poisoning During Pregnancy: Fetal Tolerance of Calcium Disodium Edetate

Loading next page...
 
/lp/american-medical-association/lead-poisoning-during-pregnancy-fetal-tolerance-of-calcium-disodium-aRqX4cx5Im
Publisher
American Medical Association
Copyright
Copyright © 1964 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1964.02090010438016
Publisher site
See Article on Publisher Site

Abstract

Abstract In the course of investigating a familial epidemic of lead poisoning due to the inhalation of fumes from burning battery cases, we had the opportunity to treat the mother of the family one month before the delivery of a normal infant.1 There have been no previous reports of calcium disodium edetate therapy during pregnancy and no mention of its effect on the fetus. Clinical observations on lead poisoning during pregnancy have been infrequent in the past 30 years. For this reason, the potential fetal toxicity of maternal lead poisoning is briefly reviewed as a preliminary to the report of this case. For over 100 years, lead poisoning in women has been considered to be associated with sterility, abortions, and high fetal and neonatal loss. In 1860, Paul2 reported that 123 pregnancies in women lead workers terminated in fetal death in 73 instances and that of the 50 live References 1. McIntire, M. S., and Angle, C. R.: Lead Poisoning in Childhood: Neurologic Sequelae , Nebraska Med J 49:412-418, 1964. 2. Paul, C.: Etude sur l'intoxication lente par les preparations de plomb; de son influence par le produit de la conception , Arch Gen Med 15: 513-533, 1860. 3. Oliver, T.: Lead Poisoning and Race , Brit Med J 1:1096, 1911.Crossref 4. Hall, H. C.: Notes on Metallic Poisoning , Texas J Med 10:308-314, 1914. 5. Holt, L. E. Jr.: Lead Poisoning in Infancy , Amer J Dis Child 25:229-233, 1923. 6. Aub, J. C., et al: Lead Poisoning , Medicine (Balt) 4:1-250, 1925. 7. Hamilton, A.: Industrial Poisons in United States , New York: The Macmillan Company, 1929, pp 8-17, 110-115. 8. Hansmann, G. H., and Perry, M. C.: Lead Absorption and Intoxication in Man Unassociated With Occupations or Industrial Hazards , Arch Path 30:226-239, 1940. 9. Cantarow, A., and Trumper, M.: Lead Poisoning , ed 1, Baltimore: The Williams & Wilkins Co., 1944. pp 84-86, 142-144. 10. Nogaki, K.: On Action of Lead on Body of Lead Refinery Workers: Particularly on Conception, Pregnancy and Parturition in Case of Females and on Vitality of Their Newborn , Acta Med (Fukuoka) 27:1314-1338, 1957; 11. abstracted, Excerpta Med (XVII) 4:2176, 1958. 12. Gillet, J. A.: Outbreak of Lead Poisoning in Canklow District of Rotherham , Lancet 1:1118-1121, 1955.Crossref 13. Travers, E.; Rendle-Short, J.; and Harvey, C. C.: Rotherham Lead-Poisoning Outbreak , Lancet 2:113-116, 1956.Crossref 14. Harvey, C. C., and Travers, E.: Personal communication to the authors. 15. Hall, A.: Increasing Use of Lead as an Abortifacient , Brit Med J 1:584-587, 1905.Crossref 16. Hall, A., and Ransom, W. B.: Plumbism From Ingestion of Diachylon as an Abortifacient , Brit Med J 1:428, 1906.Crossref 17. Pindborg, S.: Om Sølverglødforgiftning i Danmark , Ugeskr Laeg 107:1-6, 1945. 18. Hansen, A. B.: Vier Fälle von Bleivergiftung nach Einnehmen von "Silberglätte" als Abtreibungsmittel , Slg Vergift f 13:214-219, 1944. 19. Bell, W. B.: Influence of Lead on Normal and Abnormal Cell Growth , Lancet 1:268-276, 1924. 20. Karlog, O., and Moller, K. O.: Three Cases of Acute Lead Poisoning: Analyses of Organs for Lead and Observations on Polarographic Lead Determinations , Acta Pharmacol (Robenharn) 15: 8-16, 1958.Crossref 21. Laug, E. P.: Application of Dithizone Method to Determination of Lead in Biological Materials , J Ass Offic Agric Chem 21:481-487, 1938. 22. Weber, H. J.: Some Experiences With Polarographic Methods in Controlling Lead Hazard in Brass Foundries , J Industr Hyg Toxicol 29: 158-167, 1947. 23. Foreman, H. and Trujillo, T. T.: Metabolism of C14 Labeled Ethylenediamine Tetraacetic Acid in Human Beings , J Lab Clin Med 43:566-571, 1954. 24. Foreman, H.: Person communication to the authors. 25. Foreman, H.; Finegan, C.; and Lushbaugh, C. C.: Nephrotoxic Hazard From Uncontrolled Edathamil Calcium-Disodium Therapy , JAMA 160:1042-1046, 1956.Crossref 26. Smith, H. D.: Pediatric Lead Poisoning , Arch Environ Health 8:256-261, 1964.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Oct 1, 1964

References