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LAURENCE-MOON-BIEDL SYNDROME

LAURENCE-MOON-BIEDL SYNDROME In 1866, Laurence and Moon first pointed out a syndrome known in later literature (1930) as the Laurence-Moon-Biedl syndrome, the prominent clinical manifestations of which are adiposogenital dystrophia (Fröhlich's syndrome), atypical retinitis pigmentosa, often without the concomitant hyperpigmentation, mental deficiency, familial incidence and skeletal abnormalities, the most frequent of which are polydactylism, usually asymmetrical and postaxial (e. g., toward the little finger or toe), syndactylism and deformity of the skull. Since that time a total of eighty-seven cases have been presented in the literature of the world. In no case, however, was it reported that there was more than one extra digit on a single extremity, although numerous records can be found of a single extra digit on more than one extremity. Males seem to be more often affected than females, but definitely more cases have been reported among the English and the Germans than among other peoples. Not all http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

LAURENCE-MOON-BIEDL SYNDROME

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References (2)

Publisher
American Medical Association
Copyright
Copyright © 1937 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1937.04140130112013
Publisher site
See Article on Publisher Site

Abstract

In 1866, Laurence and Moon first pointed out a syndrome known in later literature (1930) as the Laurence-Moon-Biedl syndrome, the prominent clinical manifestations of which are adiposogenital dystrophia (Fröhlich's syndrome), atypical retinitis pigmentosa, often without the concomitant hyperpigmentation, mental deficiency, familial incidence and skeletal abnormalities, the most frequent of which are polydactylism, usually asymmetrical and postaxial (e. g., toward the little finger or toe), syndactylism and deformity of the skull. Since that time a total of eighty-seven cases have been presented in the literature of the world. In no case, however, was it reported that there was more than one extra digit on a single extremity, although numerous records can be found of a single extra digit on more than one extremity. Males seem to be more often affected than females, but definitely more cases have been reported among the English and the Germans than among other peoples. Not all

Journal

American journal of diseases of children – American Medical Association

Published: Jun 1, 1937

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