Abstract • Sustained intraocular pressure elevations were induced in 15 monkey eyes by argon laser photocoagulation of the trabecular meshwork. Large fluctuations of IOP resulted. Posttreatment gonioscopy revealed an open angle with scattered low peripheral anterior synechiae. Optic disc cupping progressed during pressure elevations, manifested first as posterior bowing of the optic nerve head and peripapillary tissues. Reversal of this early phase of cupping occurred in eight eyes during spontaneous normalization of IOP. In most eyes, as cupping evolved from saucerization to a deeper cup, the cup remained round. In four eyes, focal sloping of the cup to the inferotemporal rim occurred with nerve fiber layer defects. Total cupping with undermining of the rim occurred in five eyes with prolonged IOP elevation. Laser-induced primate glaucoma has features in common with juvenile human glaucoma and is a useful model for the study of cupping of the optic nerve head. References 1. Wise JB, Witter SL: Argon laser therapy for open-angle glaucoma: A pilot study . Arch Ophthalmol 1979;97:319-322.Crossref 2. Gaasterland DE, Kupfer C: Experimental glaucoma in the rhesus monkey . Invest Ophthalmol Vis Sci 1974;13:455-457. 3. Quigley HA, Hohman RM: Laser energy levels for trabecular meshwork damage in the primate eye . Invest Ophthalmol Vis Sci 1983; 24:1305-1307. 4. Gaasterland DE, Tanashima T, Kuwabara T: Axoplasmic flow during chronic experimental glaucoma: I. Light and electron microscopic studies of the monkey optic nervehead during development of glaucomatous cupping . Invest Ophthalmol Vis Sci 1978;17:838-846. 5. Duke-Elder S, Jay B: Glaucoma and hypotony , in Duke-Elder S (ed): System of Ophthalmology. London, Henry Kimpton, 1969, vol 2: Disease of the Lens and Vitreous , p 456. 6. Pederson JE, Herschler J: Reversal of glaucomatous cupping in adults . Arch Ophthalmol 1982;100:426-431.Crossref 7. Shaffer RN, Hetherington J Jr: The glaucomatous disc in infants: A suggested hypothesis for disc cupping . Trans Am Acad Ophthalmol Otolaryngol 1969;73:929-935. 8. Pederson JE, Anderson DR: The mode of progressive disc cupping in ocular hypertension and glaucoma . Arch Ophthalmol 1980;98:490-495.Crossref 9. Robin AL, Quigley HA, Pollack IP, et al: An analysis of visual acuity, visual fields, and disk cupping in childhood glaucoma . Am J Ophthalmol 1979;88:847-858.
Archives of Ophthalmology – American Medical Association
Published: Nov 1, 1984