Abstract • Larynges from 13 victims of sudden infant death syndrome (SIDS) and from ten controls of comparable age were subjected to serial histological transverse section and examined for structural differences that bear on functional performance. The cross-sectional area of mucous glands in the vestibular fold, expressed as a percent of the total cross-sectional area of the fold was 19.52 ± 8.56 (mean ± SD in the SIDS specimens), and 12.56 ± 6.25 in the controls. The difference is statistically significant and suggests that excess mucous laryngeal secretion may be present in at least some cases of the syndrome. (Am J Dis Child 134:144-146, 1980) References 1. Beckwith JB: The sudden infant death syndrome . Curr Probl Pediatr (June) 1973, pp 1-36. 2. Naeye RL: Hypoxemia and the sudden infant death syndrome . Science 186:837-838, 1974.Crossref 3. Naeye RL: Pulmonary arterial abnormalities in the sudden-infant-death syndrome . N Engl J Med 289:1167-1170, 1973.Crossref 4. Kendeel SR, Ferris JAJ: Apparent hypoxic changes in pulmonary arterioles and small arteries in infancy . J Clin Pathol 30:481-485, 1977.Crossref 5. Steinschneider AL: Prolonged apnea and the sudden infant death syndrome: Clinical and laboratory observations . Pediatrics 50:646-654, 1972. 6. Guilleminault C, Peraita R, Souquet M, et al: Apnea during sleep in infants: Possible relationship with sudden infant death syndrome . Science 190:677-679, 1975.Crossref 7. Fink BR: Spring mechanisms in the human larynx . Acta Otolaryngol 77:295-304, 1974.Crossref 8. Siegl S: Nonparametric Statistics . New York, McGraw-Hill Book Co, 1956, p 116. 9. Heiss R: Der Kehlkopf , in von Mollendorff W (ed): Handbuch der Mikroskopischen Anatomie des Menschen . New York, Springer Verlag, 1966, vol 5, pp 728-742. 10. Nassar VH, Bridger GP: Topography of the laryngeal mucous glands . Arch Otolaryngol 94:490-498, 1971.Crossref 11. Handforth CP: Sudden unexpected death in infants . Canad Med Assoc J 80:872-873, 1959. 12. Shaw EG: Sudden unexpected death in infancy syndrome . Am J Dis Child 116:115-119, 1968. 13. Downing SE, Lee JC: Laryngeal chemosensitivity: A possible mechanism for sudden infant death . Pediatrics 55:640-649, 1975. 14. Guilleminault C, Araiagno R: Sudden infant death syndrome . Bull Eur Physiopathol Respir 13:591-597, 1977. 15. Angell-James JE, Daly MB: Some aspects of upper respiratory tract reflexes . Acta Otolaryngol 79:242-252, 1975.Crossref 16. Langston C: Sudden infant death syndrome . Human Pathol 7:492-494, 1976.Crossref 17. Fink BR, Martin RW: Biomechanics of the human epiglottis , abstracted. Acta Otolaryngol 87:554-559, 1979.Crossref
American Journal of Diseases of Children – American Medical Association
Published: Feb 1, 1980
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