HISTORY OF NEUROLOGY: SEMINAL CITATIONS SECTION EDITOR: CHRISTOPHER G. GOETZ, MD Joshua Rotenberg, MD; Phillip L. Pearl, MD . . . it may be suggested that persistent convulsive discharge in brain tissue largely concerned with linguistic communication results in the functional ablation of these areas for normal linguistic behavior. William M. Landau, MD, and Frank R. Kleffner, PhD From the personal perspective of attaining three score and seven and the condition of Status Eponymicus, I can find no basis for ego gratification. William M. Landau, MD he description of Landau-Kleffner syndrome (LKS) has profoundly influenced not only clinical practice but also cognitive neuroscience. At the time of their interdisciplinary collaboration, Landau and Kleffner (Figure 1 and Figure 2) could not have known T the significance of their description of this rare disorder of communication. Landau has lamented and satirized the achievement of “status eponymicus,” given the enduring lack of rigorous data associated with the comingling of acquired aphasia and epilepsy. The central characteristics of LKS have not been significantly modified since the initial descriptions in 1957. Variations on the theme and enlargement of the spectrum have been prominent as the syndrome has become widely publicized and, to some extent,
JAMA Neurology – American Medical Association
Published: Jul 1, 2003
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