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LACTOGENIC SUBSTANCE IN THE HUMAN BREAST: ITS USE IN EXPERIMENTAL STIMULATION OF MAMMARY SECRETION AND ITS ASSAY IN CASES OF CYSTIC DISEASE

LACTOGENIC SUBSTANCE IN THE HUMAN BREAST: ITS USE IN EXPERIMENTAL STIMULATION OF MAMMARY... Abstract That there exists a relationship between the anterior lobe of the hypophysis and lactation has been shown by the work of Grüter and Stricker.1 Investigations which demonstrated the effect of extracts of the anterior lobe of the hypophysis on mammary secretion have been made by Corner,2 Nelson and Pfiffner,3 Gardner and Turner4 and Riddle, Bates and Dykshorn.5 These studies have shown that when the mammary glands of rats, guinea-pigs, rabbits and dogs have been stimulated by the injection of ovarian hormones, injections of extracts of the anterior lobe of the hypophysis may initiate secretory activity. Purified lactogenic substances have been prepared from the anterior lobe of the hypophysis by Turner6 and his co-workers and by Riddle and his co-workers. The use of these extracts and the response of the crop of the pigeon as a method of bio-assay opened new fields for the investigation References 1. Grüter, F., and Stricker, P.: Ueber die Wirkung eines Hypophysenvorderlappenhormons auf die Auslösung der Milchsekretion , Klin. Wchnschr. 8:2322, 1929.Crossref 2. Corner, G. W.: The Hormonal Control of Lactation , Am. J. Physiol. 95:43, 1930. 3. Nelson, W. O., and Pfiffner, J. J.: An Experimental Study of the Factors Concerned in Mammary Gland Growth and Milk Secretion , Proc. Soc. Exper. Biol. & Med. 28:1, 1930. 4. Gardner, W. U., and Turner, C. W.: The Function, Assay and Preparation of Galactin, a Lactation Stimulating Hormone of the Anterior Pituitary, and an Investigation of the Factors Responsible for the Control of Normal Lactation, Research Bulletin 196, Agricultural Experiment Station, University of Missouri, June 1933. 5. Riddle, O.; Bates, R. W., and Dykshorn, S. W.: The Preparation, Identification and Assay of Prolactin—A Hormone of the Anterior Pituitary , Am. J. Physiol. 105:191, 1933. 6. Turner, C. W.: Personal communication to the authors. 7. Kurzrok, R.; Bates, R. W.; Riddle, O., and Miller, E. G., Jr.: The Clinical Use of Prolactin , Endocrinology 18:18, 1934. 8. Werner, A. A.: Experiment to Produce Lactation in Castrate Women , Endocrinology 19:144, 1935. 9. Geschickter, C. F.; Lewis, D., and Hartman, C. G.: Tumors of the Breast Related to the Oestrin Hormone , Am. J. Cancer 21:828, 1934. 10. Allen, E.; Gardner, W. U., and Diddle, A. W.: Experiments with Theelin and Galactin on Growth and Function of the Mammary Glands of the Monkey , Endocrinology 19:305, 1935. 11. Drs. J. F. Anderson and J. A. Morrell, of E. R. Squibb & Sons, supplied the estrogenic substance (amniotin) and the lactogenic substance (prolactin) used in these studies. 12. Dr. and Mrs. George O. Gey, of this laboratory, cooperated in the extraction of udders and colostrum for lactogenic substance. 13. Lewis, D., and Geschickter, C. F.: Ovarian Hormones in Relation to Chronic Cystic Mastitis , Am. J. Surg. 24:280, 1934. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

LACTOGENIC SUBSTANCE IN THE HUMAN BREAST: ITS USE IN EXPERIMENTAL STIMULATION OF MAMMARY SECRETION AND ITS ASSAY IN CASES OF CYSTIC DISEASE

GESCHICKTER, CHARLES F.; LEWIS, DEAN
Archives of Surgery , Volume 32 (4) – Apr 1, 1936
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Publisher
American Medical Association
Copyright
Copyright © 1936 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1936.01180220024002
Publisher site
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Abstract

Abstract That there exists a relationship between the anterior lobe of the hypophysis and lactation has been shown by the work of Grüter and Stricker.1 Investigations which demonstrated the effect of extracts of the anterior lobe of the hypophysis on mammary secretion have been made by Corner,2 Nelson and Pfiffner,3 Gardner and Turner4 and Riddle, Bates and Dykshorn.5 These studies have shown that when the mammary glands of rats, guinea-pigs, rabbits and dogs have been stimulated by the injection of ovarian hormones, injections of extracts of the anterior lobe of the hypophysis may initiate secretory activity. Purified lactogenic substances have been prepared from the anterior lobe of the hypophysis by Turner6 and his co-workers and by Riddle and his co-workers. The use of these extracts and the response of the crop of the pigeon as a method of bio-assay opened new fields for the investigation References 1. Grüter, F., and Stricker, P.: Ueber die Wirkung eines Hypophysenvorderlappenhormons auf die Auslösung der Milchsekretion , Klin. Wchnschr. 8:2322, 1929.Crossref 2. Corner, G. W.: The Hormonal Control of Lactation , Am. J. Physiol. 95:43, 1930. 3. Nelson, W. O., and Pfiffner, J. J.: An Experimental Study of the Factors Concerned in Mammary Gland Growth and Milk Secretion , Proc. Soc. Exper. Biol. & Med. 28:1, 1930. 4. Gardner, W. U., and Turner, C. W.: The Function, Assay and Preparation of Galactin, a Lactation Stimulating Hormone of the Anterior Pituitary, and an Investigation of the Factors Responsible for the Control of Normal Lactation, Research Bulletin 196, Agricultural Experiment Station, University of Missouri, June 1933. 5. Riddle, O.; Bates, R. W., and Dykshorn, S. W.: The Preparation, Identification and Assay of Prolactin—A Hormone of the Anterior Pituitary , Am. J. Physiol. 105:191, 1933. 6. Turner, C. W.: Personal communication to the authors. 7. Kurzrok, R.; Bates, R. W.; Riddle, O., and Miller, E. G., Jr.: The Clinical Use of Prolactin , Endocrinology 18:18, 1934. 8. Werner, A. A.: Experiment to Produce Lactation in Castrate Women , Endocrinology 19:144, 1935. 9. Geschickter, C. F.; Lewis, D., and Hartman, C. G.: Tumors of the Breast Related to the Oestrin Hormone , Am. J. Cancer 21:828, 1934. 10. Allen, E.; Gardner, W. U., and Diddle, A. W.: Experiments with Theelin and Galactin on Growth and Function of the Mammary Glands of the Monkey , Endocrinology 19:305, 1935. 11. Drs. J. F. Anderson and J. A. Morrell, of E. R. Squibb & Sons, supplied the estrogenic substance (amniotin) and the lactogenic substance (prolactin) used in these studies. 12. Dr. and Mrs. George O. Gey, of this laboratory, cooperated in the extraction of udders and colostrum for lactogenic substance. 13. Lewis, D., and Geschickter, C. F.: Ovarian Hormones in Relation to Chronic Cystic Mastitis , Am. J. Surg. 24:280, 1934.

Journal

Archives of Surgery – American Medical Association

Published: Apr 1, 1936

References

  • Ueber die Wirkung eines Hypophysenvorderlappenhormons auf die Auslösung der Milchsekretion
    Grüter , F., and Stricker, P.
  • The Hormonal Control of Lactation
    Corner , G. W.
  • An Experimental Study of the Factors Concerned in Mammary Gland Growth and Milk Secretion
    Nelson , W. O., and Pfiffner, J. J.
  • The Preparation, Identification and Assay of Prolactin—A Hormone of the Anterior Pituitary
    Riddle , O.; Bates, R. W., and Dykshorn, S. W.
  • The Clinical Use of Prolactin
    Kurzrok , R.; Bates, R. W.; Riddle, O., and Miller, E. G., Jr.
  • Experiment to Produce Lactation in Castrate Women
    Werner , A. A.
  • Tumors of the Breast Related to the Oestrin Hormone
    Geschickter , C. F.; Lewis, D., and Hartman, C. G.
  • Experiments with Theelin and Galactin on Growth and Function of the Mammary Glands of the Monkey
    Allen , E.; Gardner, W. U., and Diddle, A. W.
  • Ovarian Hormones in Relation to Chronic Cystic Mastitis
    Lewis , D., and Geschickter, C. F.