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Lactate Dehydrogenase Levels and Isozyme Patterns: Measurements in the Aqueous Humor and Serum of Retinoblastoma Patients

Lactate Dehydrogenase Levels and Isozyme Patterns: Measurements in the Aqueous Humor and Serum of... Abstract • Lactate dehydrogenase (LDH) activity was determined in 24 cases of histologically proved retinoblastoma. The mean level was 1,825 IU/L, with a range of 10 to 15,920 IU/L. Twenty-two patients had elevated aqueous humor LDH levels. In two, the aqueous humor level was within the normal range. Student's t testing showed a highly significant difference between cataract and retinoblastoma aqueous humor. The retinoblastoma aqueous humor to blood ratio ranged from 0.045 to 58,529—not a good index of retinoblastoma. Isozyme patterns of retinoblastoma aqueous humor were statistically similar to those of normal cataract aqueous humor. The serum LDH level of cataract patients was not statistically different from that of retinoblastoma patients. The LDH 5/LDH 1 ratio of retinoblastoma aqueous humor ranged from 0.042 to 27.05—not a good index of retinoblastoma, as 28 of 34 aqueous samples of cataract patients had LDH 5 > LDH 1. Ten of 13 retinoblastoma patients had aqueous humor LDH 5 > LDH 1. The best index of the presence or absence of retinoblastoma is the total aqueous humor LDH level. References 1. Dias PLR, Senthe Shanmuganathau S, Rajaratnam M: Lactate dehydrogenase activity of aqueous humor in retinoblastoma . Br J Ophthalmol 55:130-132, 1971.Crossref 2. Swartz M, Herbert RW, Goldberg MF: Aqueous lactic acid dehydrogenase in retinoblastoma . Am J Ophthalmol 78:612-617, 1974. 3. Kabak J, Romano PE: Aqueous humor lactic dehydrogenase isoenzymes in retinoblastoma . Br J Ophthalmol 59:268-269, 1975.Crossref 4. Kaneko A: Lactic acid dehydrogenase activity and isoenzymes in the retinoblastoma . Acta Soc Ophthalmol Jpn 76:672-682, 1972. 5. McDonald MB, Abramson DH, Ellsworth RM, et al: Lactate dehydrogenase levels and isoenzyme patterns in the serum and aqueous humor of adult cataract patients . Arch Ophthalmol 95:2068-2069, 1977.Crossref 6. Wroblewski E, Decker B, Wroblewski R: Activity of lactic dehydrogenase in spinal fluid . Am J Pathol 28:269, 1957. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Lactate Dehydrogenase Levels and Isozyme Patterns: Measurements in the Aqueous Humor and Serum of Retinoblastoma Patients

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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1979.01020010428004
Publisher site
See Article on Publisher Site

Abstract

Abstract • Lactate dehydrogenase (LDH) activity was determined in 24 cases of histologically proved retinoblastoma. The mean level was 1,825 IU/L, with a range of 10 to 15,920 IU/L. Twenty-two patients had elevated aqueous humor LDH levels. In two, the aqueous humor level was within the normal range. Student's t testing showed a highly significant difference between cataract and retinoblastoma aqueous humor. The retinoblastoma aqueous humor to blood ratio ranged from 0.045 to 58,529—not a good index of retinoblastoma. Isozyme patterns of retinoblastoma aqueous humor were statistically similar to those of normal cataract aqueous humor. The serum LDH level of cataract patients was not statistically different from that of retinoblastoma patients. The LDH 5/LDH 1 ratio of retinoblastoma aqueous humor ranged from 0.042 to 27.05—not a good index of retinoblastoma, as 28 of 34 aqueous samples of cataract patients had LDH 5 > LDH 1. Ten of 13 retinoblastoma patients had aqueous humor LDH 5 > LDH 1. The best index of the presence or absence of retinoblastoma is the total aqueous humor LDH level. References 1. Dias PLR, Senthe Shanmuganathau S, Rajaratnam M: Lactate dehydrogenase activity of aqueous humor in retinoblastoma . Br J Ophthalmol 55:130-132, 1971.Crossref 2. Swartz M, Herbert RW, Goldberg MF: Aqueous lactic acid dehydrogenase in retinoblastoma . Am J Ophthalmol 78:612-617, 1974. 3. Kabak J, Romano PE: Aqueous humor lactic dehydrogenase isoenzymes in retinoblastoma . Br J Ophthalmol 59:268-269, 1975.Crossref 4. Kaneko A: Lactic acid dehydrogenase activity and isoenzymes in the retinoblastoma . Acta Soc Ophthalmol Jpn 76:672-682, 1972. 5. McDonald MB, Abramson DH, Ellsworth RM, et al: Lactate dehydrogenase levels and isoenzyme patterns in the serum and aqueous humor of adult cataract patients . Arch Ophthalmol 95:2068-2069, 1977.Crossref 6. Wroblewski E, Decker B, Wroblewski R: Activity of lactic dehydrogenase in spinal fluid . Am J Pathol 28:269, 1957.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: May 1, 1979

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