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Lack of Efficacy of Polysorbate 60 in the Treatment of Male Pattern Baldness

Lack of Efficacy of Polysorbate 60 in the Treatment of Male Pattern Baldness Abstract • Anecdotal reports have indicated that the nonionic detergent polysorbate 60 may be of some value in male pattern baldness. In this double-blind placebo-controlled trial, a photographic and objective scalp measurement system was developed to assess new hair growth. No significant difference was detected between subjects treated for 16 weeks with polysorbate 60 and control subjects treated with glycerin, indicating that polysorbate 60 is ineffective. Of the 141 subjects who completed the trial, 25% perceived that they grew new hair, 67% said they did not, and 8% were uncertain. Subject-reported new hair growth did not correlate with measurements, indicating that the placebo effect may be a major factor in reports of baldness "cures." (Arch Intern Med 1985;145:1454-1458) References 1. Hair raising treatment, editorial. Br Med J 1979;2:953-954. 2. Uno H, Adachi K, Montagna W: Morphological and biochemical studies of hair follicle in common baldness of stump-tailed macaque , in Montagna W, Dobson RL (eds): Advances in Biology: Hair Growth . Oxford, England, Pergamon Press, 1969, pp 221-245. 3. Herten RJ: Nonscarring hair loss disorders. Postgrad Med 1982;72: 231-246. 4. Burton JL, Ben Halim MM, Meyrick G, et al: Male-pattern alopecia and masculinity. Br J Dermatol 1979;100:567-571.Crossref 5. Price V: Testosterone metabolism of the skin. Arch Dermatol 1975;111:1496-1502.Crossref 6. Seidman M, Westfried M, Maxey R, et al: Reversal of male pattern baldness by minoxidil: A case report. Cutis 1981;28:551-553. 7. Schreck-Purola I, Setala K: Safety and mode of effect of a hair preparation. Contributions From the First Department of Pathology and Its Radiological Laboratory of University of Helsinki 1974;1:1-36. 8. McNulty PB: Effect of polysorbate 60 on interphase transport of cholesterol. J Pharm Sci 1975;64:1500-1503.Crossref 9. Pearson D, Shaw S: Life Extension . New York, Warner Books Inc, 1982, pp 218-221. 10. Mantel N: Chi-square test with one degree of freedom: Extensions of the Mantel-Haenszel procedure. J Am Statist Assoc 1963;58:690-700. 11. Dixon WJ, Massey FJ Jr: Introduction to Statistical Analysis , ed 3. New York, McGraw-Hill Book Co, 1969, pp 341-345. 12. Fleiss JL: Statistical Methods for Rates and Proportions , ed 2. New York, John Wiley & Sons Inc, 1981, pp 212-232. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Lack of Efficacy of Polysorbate 60 in the Treatment of Male Pattern Baldness

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Publisher
American Medical Association
Copyright
Copyright © 1985 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1985.00360080132020
Publisher site
See Article on Publisher Site

Abstract

Abstract • Anecdotal reports have indicated that the nonionic detergent polysorbate 60 may be of some value in male pattern baldness. In this double-blind placebo-controlled trial, a photographic and objective scalp measurement system was developed to assess new hair growth. No significant difference was detected between subjects treated for 16 weeks with polysorbate 60 and control subjects treated with glycerin, indicating that polysorbate 60 is ineffective. Of the 141 subjects who completed the trial, 25% perceived that they grew new hair, 67% said they did not, and 8% were uncertain. Subject-reported new hair growth did not correlate with measurements, indicating that the placebo effect may be a major factor in reports of baldness "cures." (Arch Intern Med 1985;145:1454-1458) References 1. Hair raising treatment, editorial. Br Med J 1979;2:953-954. 2. Uno H, Adachi K, Montagna W: Morphological and biochemical studies of hair follicle in common baldness of stump-tailed macaque , in Montagna W, Dobson RL (eds): Advances in Biology: Hair Growth . Oxford, England, Pergamon Press, 1969, pp 221-245. 3. Herten RJ: Nonscarring hair loss disorders. Postgrad Med 1982;72: 231-246. 4. Burton JL, Ben Halim MM, Meyrick G, et al: Male-pattern alopecia and masculinity. Br J Dermatol 1979;100:567-571.Crossref 5. Price V: Testosterone metabolism of the skin. Arch Dermatol 1975;111:1496-1502.Crossref 6. Seidman M, Westfried M, Maxey R, et al: Reversal of male pattern baldness by minoxidil: A case report. Cutis 1981;28:551-553. 7. Schreck-Purola I, Setala K: Safety and mode of effect of a hair preparation. Contributions From the First Department of Pathology and Its Radiological Laboratory of University of Helsinki 1974;1:1-36. 8. McNulty PB: Effect of polysorbate 60 on interphase transport of cholesterol. J Pharm Sci 1975;64:1500-1503.Crossref 9. Pearson D, Shaw S: Life Extension . New York, Warner Books Inc, 1982, pp 218-221. 10. Mantel N: Chi-square test with one degree of freedom: Extensions of the Mantel-Haenszel procedure. J Am Statist Assoc 1963;58:690-700. 11. Dixon WJ, Massey FJ Jr: Introduction to Statistical Analysis , ed 3. New York, McGraw-Hill Book Co, 1969, pp 341-345. 12. Fleiss JL: Statistical Methods for Rates and Proportions , ed 2. New York, John Wiley & Sons Inc, 1981, pp 212-232.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Aug 1, 1985

References