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Lack of Efficacy of Citalopram in Children With Autism Spectrum Disorders and High Levels of Repetitive Behavior

Lack of Efficacy of Citalopram in Children With Autism Spectrum Disorders and High Levels of... ORIGINAL ARTICLE Lack of Efficacy of Citalopram in Children With Autism Spectrum Disorders and High Levels of Repetitive Behavior Citalopram Ineffective in Children With Autism Bryan H. King, MD; Eric Hollander, MD; Linmarie Sikich, MD; James T. McCracken, MD; Lawrence Scahill, MSN, PhD; Joel D. Bregman, MD; Craig L. Donnelly, MD; Evdokia Anagnostou, MD; Kimberly Dukes, PhD; Lisa Sullivan, PhD; Deborah Hirtz, MD; Ann Wagner, PhD; Louise Ritz, MBA; for the STAART Psychopharmacology Network Context: Selective serotonin reuptake inhibitors are widely Main Outcome Measures: Positive response was de- prescribed for children with autism spectrum disorders. fined by a score of much improved or very much im- proved on the Clinical Global Impressions, Improve- Objectives: To determine the efficacy and safety of cital- ment subscale. An important secondary outcome was the opram hydrobromide therapy for repetitive behavior in score on the Children’s Yale-Brown Obsessive Compul- children with autism spectrum disorders. sive Scales modified for pervasive developmental disor- ders. Adverse events were systematically elicited using Design: National Institutes of Health–sponsored ran- the Safety Monitoring Uniform Report Form. domized controlled trial. Results: There was no significant difference in the rate of Setting: Six academic centers, including Mount Sinai positive response on the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2009 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/archgenpsychiatry.2009.30
pmid
19487623
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Lack of Efficacy of Citalopram in Children With Autism Spectrum Disorders and High Levels of Repetitive Behavior Citalopram Ineffective in Children With Autism Bryan H. King, MD; Eric Hollander, MD; Linmarie Sikich, MD; James T. McCracken, MD; Lawrence Scahill, MSN, PhD; Joel D. Bregman, MD; Craig L. Donnelly, MD; Evdokia Anagnostou, MD; Kimberly Dukes, PhD; Lisa Sullivan, PhD; Deborah Hirtz, MD; Ann Wagner, PhD; Louise Ritz, MBA; for the STAART Psychopharmacology Network Context: Selective serotonin reuptake inhibitors are widely Main Outcome Measures: Positive response was de- prescribed for children with autism spectrum disorders. fined by a score of much improved or very much im- proved on the Clinical Global Impressions, Improve- Objectives: To determine the efficacy and safety of cital- ment subscale. An important secondary outcome was the opram hydrobromide therapy for repetitive behavior in score on the Children’s Yale-Brown Obsessive Compul- children with autism spectrum disorders. sive Scales modified for pervasive developmental disor- ders. Adverse events were systematically elicited using Design: National Institutes of Health–sponsored ran- the Safety Monitoring Uniform Report Form. domized controlled trial. Results: There was no significant difference in the rate of Setting: Six academic centers, including Mount Sinai positive response on the

Journal

JAMA PsychiatryAmerican Medical Association

Published: Jun 1, 2009

References

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