ORIGINAL ARTICLE Lack of Efficacy of Citalopram in Children With Autism Spectrum Disorders and High Levels of Repetitive Behavior Citalopram Ineffective in Children With Autism Bryan H. King, MD; Eric Hollander, MD; Linmarie Sikich, MD; James T. McCracken, MD; Lawrence Scahill, MSN, PhD; Joel D. Bregman, MD; Craig L. Donnelly, MD; Evdokia Anagnostou, MD; Kimberly Dukes, PhD; Lisa Sullivan, PhD; Deborah Hirtz, MD; Ann Wagner, PhD; Louise Ritz, MBA; for the STAART Psychopharmacology Network Context: Selective serotonin reuptake inhibitors are widely Main Outcome Measures: Positive response was de- prescribed for children with autism spectrum disorders. fined by a score of much improved or very much im- proved on the Clinical Global Impressions, Improve- Objectives: To determine the efficacy and safety of cital- ment subscale. An important secondary outcome was the opram hydrobromide therapy for repetitive behavior in score on the Children’s Yale-Brown Obsessive Compul- children with autism spectrum disorders. sive Scales modified for pervasive developmental disor- ders. Adverse events were systematically elicited using Design: National Institutes of Health–sponsored ran- the Safety Monitoring Uniform Report Form. domized controlled trial. Results: There was no significant difference in the rate of Setting: Six academic centers, including Mount Sinai positive response on the
JAMA Psychiatry – American Medical Association
Published: Jun 1, 2009
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